Journal of the American Chemical Society,
Год журнала:
2016,
Номер
138(17), С. 5623 - 5633
Опубликована: Апрель 11, 2016
The
first
copper-catalyzed
direct
β-functionalization
of
saturated
ketones
is
reported.
This
protocol
enables
diverse
to
couple
with
a
wide
range
nitrogen,
oxygen
and
carbon
nucleophiles
in
generally
good
yields
under
operationally
simple
conditions.
detailed
mechanistic
studies
including
kinetic
studies,
KIE
measurements,
identification
reaction
intermediates,
EPR
UV–visible
experiments
were
conducted,
which
reveal
that
this
proceeds
via
novel
radical-based
dehydrogenation
enone
subsequent
conjugate
addition
sequence.
Green Chemistry,
Год журнала:
2016,
Номер
18(12), С. 3471 - 3493
Опубликована: Янв. 1, 2016
This
review
summarizes
the
development
of
user-friendly,
recyclable
and
easily
separable
heterogeneous
catalysts
for
C–H
activation
during
last
decade
until
December
2015.
Chemical Communications,
Год журнала:
2018,
Номер
54(89), С. 12561 - 12569
Опубликована: Янв. 1, 2018
Recent
advances
in
the
sulfonylation
of
C-H
bonds
with
insertion
sulfur
dioxide
are
summarized.
Usually,
a
surrogate,
DABCO·(SO2)2,
is
used,
which
avoids
utilization
gaseous
transformation.
Inorganic
sulfites
such
as
sodium
metabisulfite
also
effective
C(sp3)-H
bond
sulfonylation.
under
transition
metal
catalysis
or
through
radical
process
has
been
developed.
In
some
cases,
can
be
performed
catalyst-
and
additive-free
conditions,
facilitated
by
visible
light
irradiation.
The
efficiency
investigated
merging
catalysis.
Journal of the American Chemical Society,
Год журнала:
2016,
Номер
138(34), С. 10750 - 10753
Опубликована: Авг. 16, 2016
Most
chelation-assisted
aliphatic
C-H
activation
proceeds
through
a
kinetically
favored
five-membered
cyclometalated
intermediate.
Here,
we
report
the
first
site-selective
alkenylation
of
δ-C(sp(3))-H
in
presence
more
accessible
γ-C(sp(3))-H
bonds
via
less
six-membered
palladacycle.
A
wide
range
functional
groups
are
tolerated,
and
unique
protocol
can
be
applied
to
synthesis
chiral
piperidines.
Moreover,
mechanistic
insights
have
been
conducted
elucidate
origin
unusual
site-selectivity.
Chemical Reviews,
Год журнала:
2019,
Номер
119(12), С. 7113 - 7278
Опубликована: Апрель 16, 2019
A
significant
number
of
important
acyl-transfer
reactions,
such
as
direct
acylation,
ortho
heteroatom
and
a
diversity
cyclization
reactions
using
the
title
compound
key
starting
material,
have
been
described
in
recent
years.
Just
like
sleeping
beauty,
α-oxocarboxylic
acids
were
awakened
from
17-year
sleep
to
become
reagents
classical
new
acylation
reactions.
The
greener
characteristic
coproduct
formed
α-keto
acid
(only
CO2),
together
with
its
versatility
building
block
catalytic
organic
synthesis,
accredit
it
candidate
green
acylating
agent,
an
alternative
acyl
chloride,
other
reagents.
This
review
presents
impressive
breakthroughs
achieved
mainly
past
decade
development
for
formation
C-C,
C-N,
C-S
bonds
acids.
Journal of the American Chemical Society,
Год журнала:
2016,
Номер
138(17), С. 5623 - 5633
Опубликована: Апрель 11, 2016
The
first
copper-catalyzed
direct
β-functionalization
of
saturated
ketones
is
reported.
This
protocol
enables
diverse
to
couple
with
a
wide
range
nitrogen,
oxygen
and
carbon
nucleophiles
in
generally
good
yields
under
operationally
simple
conditions.
detailed
mechanistic
studies
including
kinetic
studies,
KIE
measurements,
identification
reaction
intermediates,
EPR
UV–visible
experiments
were
conducted,
which
reveal
that
this
proceeds
via
novel
radical-based
dehydrogenation
enone
subsequent
conjugate
addition
sequence.
