ACS Catalysis,
Год журнала:
2018,
Номер
8(3), С. 2242 - 2246
Опубликована: Фев. 6, 2018
Through
radical-induced
tandem
triple
C–H
aminations
with
free
amines
as
the
aminating
agents,
we
herein
present
a
precedent
on
aerobic
copper-catalyzed
synthesis
of
5-diarylamino
benzimidazoles,
class
optoelectronic
device
analogues
by
combining
two
molecules
diarylamines
and
one
molecule
alkylamine
in
single
operation.
The
developed
chemistry
proceeds
merits
natural
abundant
copper/O2
catalyst
system,
readily
available
feedstocks,
broad
substrate
scope,
good
functional
group
tolerance,
exclusive
regio-
chemoselectivity,
high
step
atom
efficiency,
which
offers
an
important
basis
for
further
construction
products
that
are
inaccessible
or
difficult
to
prepare
existing
methods
employing
catalytic
amination
strategy.
Chemical Reviews,
Год журнала:
2017,
Номер
117(19), С. 12357 - 12384
Опубликована: Сен. 27, 2017
The
alkyl
group
is
the
most
common
component
of
organic
molecules
and
difficult
to
selectively
functionalize.
development
catalysts
for
dehydrogenation
groups
give
corresponding
olefins
could
open
almost
unlimited
avenues
functionalization.
Homogeneous
systems,
or
more
generally
systems
based
on
molecular
(including
solid-supported)
catalysts,
probably
offer
greatest
potential
regio-
chemoselective
alkanes.
progress
date
in
this
area
has
been
achieved
with
pincer-ligated
transition-metal-based
catalysts;
related
chemistry
are
subject
review.
Chemists
still
far
from
achieving
obvious
perhaps
attractive
goal
area,
simple
alkanes
yield
alkenes
(specifically
monoenes)
high
selectivity.
Greater
made
tandem
catalysis
approaches
which
initial
dehydrogenated
product
undergoes
a
desirable
secondary
reaction.
Also
reviewed
substantial
that
closely
substrates
containing
heteroatoms.
Advanced Synthesis & Catalysis,
Год журнала:
2017,
Номер
359(19), С. 3332 - 3340
Опубликована: Май 26, 2017
Abstract
Triazole‐phosphine‐copper
complexes
(TAP−Cu)
have
been
synthesized
and
applied
as
tunable
efficient
catalysts
for
the
selective
synthesis
of
fluoro‐substituted
2‐aryl‐1
H
‐benzo[d]imidazole
1‐benzyl‐2‐aryl‐1
derivatives
from
simple
alcohols
in
only
one
step.
TAP−Cu
exhibited
excellent
catalytic
activity
both
dehydrogenation
borrowing
hydrogen
reactions
with
more
than
80
examples
being
demonstrated
first
time.
It
was
observed
that
ligand
played
a
critical
role
catalyst
activity.
Mechanistic
studies
deuterium
labeling
experiments
indicated
proceeded
by
an
initial
reversible
alcohol
resulting
copper
hydride
intermediate.
This
also
supported
direct
observation
diagnostic
signal
solid‐state
infrared
spectroscopy.
The
TAP−Cu‐H
complex
showed
absorptions
at
912
cm
−1
could
be
assigned
to
copper−hydride
stretches.
Furthermore,
trapping
intermediate
bisimine
successfully
performed.
magnified
image
Green Chemistry,
Год журнала:
2018,
Номер
20(11), С. 2571 - 2577
Опубликована: Янв. 1, 2018
A
BINAP-Cu
system
supported
by
hydrotalcite
has
been
developed
and
proved
to
be
a
highly
efficient
catalyst
for
the
atom-efficient
green
borrowing
hydrogen
reaction
dehydrogenative
cyclization.
ACS Catalysis,
Год журнала:
2017,
Номер
7(7), С. 4780 - 4785
Опубликована: Июнь 12, 2017
Until
now,
the
selective
(hetero)aryl
C–H
alkylation
without
assistance
of
directing
groups
or
preinstallation
functionalities
still
remains
a
highly
challenging
goal.
Herein,
by
developing
acid-resistant
multispherical
cavity
carbon-supported
cobalt
oxide
nanocatalysts
(CoOx/MSCC)
and
hydrogen
transfer-mediated
activation
mode
for
nonactivated
N-heteroaromatics,
we
present
direct
reductive
quinolyl
isoquinolyl
β-C–H
with
various
aldehydes
as
alkylating
agents.
The
catalytic
transformation
features
broad
substrate
scope,
good
functional
tolerance,
use
Earth-abundant
reusable
catalysts,
no
need
prefunctionalizations,
demonstrating
that
developed
enable
one
to
directly
functionalize
inert
N-heteroaryl
systems
are
difficult
realize
organometallic
complexes.
Angewandte Chemie International Edition,
Год журнала:
2017,
Номер
56(45), С. 14232 - 14236
Опубликована: Сен. 19, 2017
A
general
catalytic
hydrogen
transfer-mediated
α-functionalization
of
1,8-naphthyridines
is
reported
for
the
first
time
that
benefits
from
a
activation
mode
non-activated
pyridyl
cores.
The
α-site
selectively
couples
with
C8-site
various
tetrahydroquinolines
(THQs)
to
afford
novel
α-functionalized
tetrahydro
1,8-naphthyridines,
class
synthetically
useful
building
blocks
and
potential
candidates
discovery
therapeutic
bio-active
products.
utilization
THQs
as
inactive
donors
(HDs)
appears
be
key
strategy
overcome
over-hydrogenation
barrier
address
chemoselectivity
issue.
developed
chemistry
features
operational
simplicity,
readily
available
catalyst
good
functional
group
tolerance,
offers
significant
basis
further
development
new
protocols
directly
transform
or
functionalize
inert
N-heterocycles.
ACS Catalysis,
Год журнала:
2018,
Номер
8(7), С. 5869 - 5874
Опубликована: Май 25, 2018
By
employing
a
MOF-templated
method,
we
have
developed
highly
dipersed
and
ultralow
loading
cobalt
nanocatalyst,
which
has
been
applied
in
the
oxidative
functionalization
of
easily
available
cyclic
amines
with
2-aminoarylmethanols
to
ring-fused
quinazolinones,
core
structures
numerous
valuable
products.
The
catalytic
transformation
proceeds
merits
broad
substrate
scope,
good
functional
group
tolerance
chemoselectivity,
high
step-
atom-efficiency,
use
naturally
abundant
Co/O2
system,
offers
practical
way
for
preparation
quinazolinones
structural
diversity.
work
presented
built
an
important
basis
direct
conversion
amine
motifs
into
frameworks.
Green Chemistry,
Год журнала:
2019,
Номер
21(20), С. 5683 - 5690
Опубликована: Янв. 1, 2019
Metal-free,
base-free,
biomimetic,
and
chemoselective
synthesis
of
2,4,6-trisubstituted
pyridines
was
developed
for
the
first
time
under
mild
conditions.
