Rapid
wound
dressing
and
effective
antibacterial
therapy
that
meet
the
extreme
requirements
of
emergency
situations
are
urgently
needed
for
treating
skin
wounds.
Here,
an
in
situ
deposited
personalized
nanofibrous
is
reported
which
can
be
directly
electrospun
on
wounds
by
a
handheld
electrospinning
device
perfectly
fits
different
various
sizes.
Moreover,
aggregation-induced
emission
luminogen
with
photodynamic
effect
loaded
dressings
endows
dressing's
long-term
activity
during
healing
process.
The
nanofibers
show
excellent
antimicrobial
against
Staphylococcus
aureus
(S.
aureus)
methicillin-resistant
aureus.
In
vivo
studies
demonstrate
these
effectively
reduce
inflammation
significantly
accelerate
healing.
Such
produced
promising
as
total
solution
emergencies,
including
patient-specific
clinical
military
injuries.
Journal of Controlled Release,
Год журнала:
2021,
Номер
334, С. 463 - 484
Опубликована: Март 27, 2021
Drug
delivery
devices
are
promising
tools
in
the
pharmaceutical
field,
as
they
able
to
maximize
therapeutic
effects
of
delivered
drug
while
minimizing
undesired
side
effects.
In
past
years,
electrospun
nanofibers
attracted
rising
attention
due
their
unique
features,
like
biocompatibility
and
broad
flexibility.
Incorporation
active
principles
nanofibrous
meshes
proved
be
an
efficient
method
for
situ
a
wide
range
drugs,
expanding
possibility
applicability
those
devices.
this
review,
principle
electrospinning
different
fields
applications
treated
give
overview
recent
literature,
underlining
easy
tuning
endless
combination
technique,
that
future
could
new
frontier
personalized
medicine.
Journal of Nanobiotechnology,
Год журнала:
2021,
Номер
19(1)
Опубликована: Янв. 4, 2021
Abstract
Skin
is
the
body’s
first
barrier
against
external
pathogens
that
maintains
homeostasis
of
body.
Any
serious
damage
to
skin
could
have
an
impact
on
human
health
and
quality
life.
Tissue
engineering
aims
improve
damaged
tissue
regeneration.
One
most
effective
treatments
for
regeneration
angiogenesis
during
healing
period.
Over
last
decade,
there
has
been
impressive
growth
new
potential
applications
nanobiomaterials
in
engineering.
Various
approaches
developed
rate
process
using
angiogenic
nanomaterials.
In
this
review,
we
focused
molecular
mechanisms
key
factors
angiogenesis,
role
scaffold-based
accelerated
wound
based
improved
angiogenesis.
Polymers,
Год журнала:
2017,
Номер
9(8), С. 364 - 364
Опубликована: Авг. 16, 2017
Biosensors
that
detect
and
convert
biological
reactions
to
a
measurable
signal
have
gained
much
attention
in
recent
years.
Between
1950
2017,
more
than
150,000
papers
been
published
addressing
the
applications
of
biosensors
different
industries,
but
best
our
knowledge
through
careful
screening,
critical
reviews
describe
hydrogel
based
for
biomedical
are
rare.
This
review
discusses
application
biosensors,
on
search
performed
Web
Science
Core,
PubMed
(NLM),
Direct
online
databases
years
2000–2017.
In
this
review,
we
consider
bioreceptors
be
immobilized
their
advantages
disadvantages,
immobilization
techniques.
We
identify
hydrogels
most
favored
type
biosensor,
as
well
predominant
transduction
strategies.
explain
including
cell
metabolite
pathogen
detection,
tissue
engineering,
wound
healing,
cancer
monitoring,
strategies
small
biomolecules
such
glucose,
lactate,
urea,
cholesterol
detection
identified.
ACS Applied Bio Materials,
Год журнала:
2019,
Номер
2(3), С. 952 - 969
Опубликована: Янв. 31, 2019
Electrospinning
is
a
versatile
technique
used
to
create
native
tissue-like
fibrous
scaffolds.
Recently,
it
has
gained
large
amount
of
attention
for
generation
bioactive
dressing
materials
suitable
treatment
both
chronic
and
acute
wounds.
In
this
Review,
we
focus
on
the
latest
advances
made
in
application
electrospun
scaffolds
wound
healing.
We
first
provide
brief
overview
healing
process
electrospinning
approaches.
then
discuss
fabrication
from
natural
synthetic
polymers
via
effective
management.
Natural
included
our
Review
cover
protein
based
such
as
collagen,
gelatin,
silk
polysaccharide
chitosan,
hyaluronic
acid,
alginate.
addition,
aliphatic
polyesters,
super
hydrophilic
polymers,
polyurethanes
some
most
commonly
applications.
Next,
review
multifunctional
"smart"
developed
by
place
an
emphasis
how
flexibility
enables
production
advanced
core-shell
scaffolds,
multilayer
surface
modified
Taken
together,
clear
that
emerging
technology
provides
unique
opportunity
engineering
more
dressing,
management,
care
products.
Abstract
Tissue
engineering
uses
a
combination
of
cell
biology,
chemistry,
and
biomaterials
to
fabricate
three
dimensional
(3D)
tissues
that
mimic
the
architecture
extracellular
matrix
(ECM)
comprising
diverse
interwoven
nanofibrous
structure.
Among
several
methods
for
producing
scaffolds,
electrospinning
has
gained
intense
interest
because
it
can
make
nanofibers
with
porous
structure
high
specific
surface
area.
The
processing
solution
parameters
considerably
affect
assembly
structural
morphology
fabricated
nanofibers.
Electrospun
be
made
from
natural
or
synthetic
polymers
blending
them
is
straightforward
way
tune
functionality
Furthermore,
electrospun
functionalized
various
modification
strategies.
In
this
review,
we
highlight
latest
achievements
in
fabricating
describe
ways
modify
scaffolds
promote
their
functionality.
We
also
summarize
application
advanced
polymeric
regeneration
human
bone,
cartilage,
vascular
tissues,
tendons/ligaments.
