Organometallics,
Год журнала:
2018,
Номер
37(17), С. 2832 - 2836
Опубликована: Авг. 28, 2018
The
first
copper-mediated
diastereoselective
C–H
thiolation
of
ferrocenes
has
been
developed.
A
chiral
oxazoline
directing
group
with
tert-butyl
substituent
is
essential
to
the
high
diastereoselectivity
ratio
and
suppression
overreaction
monothiolated
products.
This
reaction
tolerated
various
functional
groups
on
arylthiols,
implying
its
potential
application
in
N,S-bidentate
planar
ligands.
Organic Letters,
Год журнала:
2018,
Номер
20(7), С. 1794 - 1797
Опубликована: Март 9, 2018
The
utilization
of
the
transient
directing
strategy
into
direct
oxidative
dehydrogenative
arylation
aldehydes
with
arenes
was
reported
for
first
time.
Featured
by
mild
reaction
conditions,
good
functional
group
compatibility,
and
great
regioselectivity,
method
should
find
broad
applications
in
new
medicine
material
development
discovery
processes.
Organic Letters,
Год журнала:
2018,
Номер
20(7), С. 1837 - 1840
Опубликована: Март 14, 2018
A
highly
efficient
synthesis
of
planar
chiral
pyrido[3,4-
b]
ferrocenes
by
a
palladium-catalyzed
enantioselective
isocyanide
insertion/desymmetric
C(sp2)-H
bond
activation
reaction
was
developed.
Various
pyridoferrocenes
were
obtained
in
high
yields
with
good
to
excellent
enantioselectivity
under
mild
conditions
(up
99%
yield,
ee),
enabled
unique
SPINOL-derived
phosphoramidite
ligand.
Angewandte Chemie International Edition,
Год журнала:
2020,
Номер
59(24), С. 9428 - 9432
Опубликована: Март 10, 2020
Abstract
Twofold
C−H
annulation
of
readily
available
formamides
and
alkynes
without
built‐in
chelating
groups
was
achieved.
Ni−Al
bimetallic
catalysis
enabled
by
a
bulky
BINOL‐derived
chiral
secondary
phosphine
oxide
(SPO)
ligand
proved
to
be
critical
for
high
reactivity
selectivity.
This
reaction
uses
as
starting
materials
provides
concise
synthetic
pathway
broad
range
ferrocenes
in
40–98
%
yield
93–99
ee
.
Nature Communications,
Год журнала:
2019,
Номер
10(1)
Опубликована: Сен. 13, 2019
Abstract
Planar
chiral
ferrocenes
have
received
great
attention
in
both
academia
and
industry.
Although
remarkable
progresses
been
made
over
the
past
decade,
development
of
efficient
straightforward
methods
for
synthesis
enantiopure
planar
remains
highly
challenging.
Herein,
we
report
a
rhodium(I)/phosphonite
catalyzed
thioketone-directed
enantioselective
C-H
bond
arylation
ferrocenes.
Readily
available
aryl
iodides
are
used
as
coupling
partners
this
transformation,
leading
to
series
good
yields
excellent
enantioselectivities
(up
86%
yield,
99%
ee
).
Of
particular
note,
heteroaryl
coupled
ferrocenes,
which
difficult
access
with
previous
approaches,
can
be
obtained
satisfactory
results.
Organometallics,
Год журнала:
2018,
Номер
37(17), С. 2832 - 2836
Опубликована: Авг. 28, 2018
The
first
copper-mediated
diastereoselective
C–H
thiolation
of
ferrocenes
has
been
developed.
A
chiral
oxazoline
directing
group
with
tert-butyl
substituent
is
essential
to
the
high
diastereoselectivity
ratio
and
suppression
overreaction
monothiolated
products.
This
reaction
tolerated
various
functional
groups
on
arylthiols,
implying
its
potential
application
in
N,S-bidentate
planar
ligands.
