Chemical Science, Год журнала: 2022, Номер 13(14), С. 4103 - 4108
Опубликована: Янв. 1, 2022
An asymmetric [1,2] Stevens rearrangement was realized via chiral guanidine and copper( i ) complexes. A series of novel dithioketal derivatives were obtained with good yields (up to 90% yield) enantioselectivities 96 : 4 er).
Язык: Английский
Natural Product Reports, Год журнала: 2020, Номер 38(3), С. 586 - 667
Опубликована: Окт. 6, 2020
Covering: 2017-2019Guanidine natural products isolated from microorganisms, marine invertebrates and terrestrial plants, amphibians spiders, represented by non-ribosomal peptides, guanidine-bearing polyketides, alkaloids, terpenoids shikimic acid derived, are the subject of this review. The topics include discovery new metabolites, total synthesis guanidine compounds, biological activity mechanism-of-action, biosynthesis ecological functions.
Язык: Английский
Процитировано
42
ACS Catalysis, Год журнала: 2021, Номер 11(10), С. 6316 - 6324
Опубликована: Май 11, 2021
Chiral N-heterocyclic carbenes (NHCs) have been recently established as powerful catalysts for enantioselective bond-forming processes via noncovalent interactions. The underlying HOMO-raising activation of nucleophiles takes advantage the strong Brønsted basicity NHCs. However, scope compatible electrophiles has quite limited. In this article, we report a bifunctional NHC with an embedded hydrogen-bonding motif that shows remarkable tolerance various Michael acceptors in asymmetric aza-conjugate addition reaction. catalytic efficiency far exceeds benchmark tertiary amine-thiourea scaffold.
Язык: Английский
Процитировано
37
Dalton Transactions, Год журнала: 2022, Номер 51(6), С. 2567 - 2576
Опубликована: Янв. 1, 2022
The development of heterogeneous catalysts for promoting epoxide cycloaddition with carbon dioxide is highly desirable recycling CO2 and achieving the goal neutrality. Herein, we designed synthesized Zr-based metal organic frameworks (MOFs) by implanting functional guanidyl into framework via mixing different molar ratios 4-guanidinobenzoic acid (Gua) 1,4-benzenedicarboxylic (BDC). Consequently, a small sized Zr-MOF (∼350 nm) can be prepared Gua 20% ligands, denoted as UiO-66-Gua0.2(s). Compared to large Zr-MOFs, UiO-66-Gua0.2(s) exhibited an optimal activity on catalyzing in presence Bu4NBr cocatalyst. A yield 97% product chloropropene carbonate was achieved at 90 °C under 1 atm CO2. great performance might attributed synergistic effect groups hydrogen-bond donors Zr centers acting Lewis-acidic sites. In addition, catalyst versatility towards converting other epoxides satisfactory recyclability five consecutive runs. Moreover, plausible reaction mechanism has been proposed reactions.
Язык: Английский
Процитировано
24
European Journal of Organic Chemistry, Год журнала: 2022, Номер 26(7)
Опубликована: Дек. 15, 2022
Abstract Thiourea‐ and squaramide‐based bifunctional base catalysts represent nowadays a powerful tool in the field of asymmetric catalysis have demonstrated very efficient for promoting wide variety transformations enantioselectively. New versions that incorporate one or various additional H‐bond donor site(s) catalyst structure been developed recently which led to more active (reduced loadings) selective catalysts. This review highlights pioneering ideas most recent contributions area with material organized according nature functionality. The advantages, current limitations perspectives these new multifunctional are discussed.
Язык: Английский
Процитировано
24
Chemical Science, Год журнала: 2022, Номер 13(14), С. 4103 - 4108
Опубликована: Янв. 1, 2022
An asymmetric [1,2] Stevens rearrangement was realized via chiral guanidine and copper( i ) complexes. A series of novel dithioketal derivatives were obtained with good yields (up to 90% yield) enantioselectivities 96 : 4 er).
Язык: Английский
Процитировано
23