Environmental Stressors on Skin Aging. Mechanistic Insights

Frontiers in Pharmacology, Год журнала: 2019, Номер 10

Опубликована: Июль 9, 2019

The skin is the main barrier that protects us against environmental stressors (physical, chemical and biological). These stressors, combined with internal factors, are responsible for cutaneous aging throughout life. Furthermore, they also negatively impact represent an increased risk of diseases, particularly cancer. This review addresses on aging, especially those related to general specific external factors (lifestyles, occupations, pollutants light exposure). More specifically, we have evaluated ambient air pollution, household from non-combustion sources, exposure (UV radiation, blue red light). We approach molecular pathways involved in pathology, as a result these stressors. Finally, make reflection how several components stress can interact ultraviolet radiation cause cell damage critical importance knowing mechanisms develop new therapies maintain without old age repair diseases skin.

Язык: Английский

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Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Allergy, Год журнала: 2022, Номер 77(5), С. 1418 - 1449

Опубликована: Фев. 2, 2022

Environmental exposure plays a major role in the development of allergic diseases. The exposome can be classified into internal (e.g., aging, hormones, and metabolic processes), specific external chemical pollutants or lifestyle factors), general broader socioeconomic psychological contexts) domains, all which are interrelated. All factors we exposed to, from moment conception to death, part exposome. Several hundreds thousands new chemicals have been introduced modern life without our having full understanding their toxic health effects ways mitigate these effects. Climate change, air pollution, microplastics, tobacco smoke, changes loss biodiversity, alterations dietary habits, microbiome due modernization, urbanization, globalization constitute surrounding environment Some disrupt epithelial barriers skin mucosal surfaces, disruptions linked last few decades increasing prevalence severity inflammatory diseases such as atopic dermatitis, food allergy, rhinitis, chronic rhinosinusitis, eosinophilic esophagitis, asthma. barrier hypothesis provides mechanistic explanation how explain rapid increase autoimmune In this review, discuss affecting planet's context 'epithelial hypothesis,' including climate emphasize on addition, roles increased fatty acid consumption environmental substances (detergents, airborne pollen, ozone, nanoparticles, tobacco) discussed. Considering emerging data recent studies, suggest stringent governmental regulations, global policy adjustments, patient education, establishment individualized control measures threats decrease disease.

Язык: Английский

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Oxidation and fragmentation of plastics in a changing environment; from UV-radiation to biological degradation

The Science of The Total Environment, Год журнала: 2022, Номер 851, С. 158022 - 158022

Опубликована: Авг. 12, 2022

Understanding the fate of plastics in environment is critical importance for quantitative assessment biological impacts plastic waste. Specially, there a need to analyze more detail reputed longevity context degradation through oxidation and fragmentation reactions. Photo-oxidation debris by solar UV radiation (UVR) makes material prone subsequent fragmentation. The fragments generated following exposure mechanical stresses include secondary micro- or nanoparticles, an emerging class pollutants. paper discusses UV-driven photo-oxidation process, identifying relevant knowledge gaps uncertainties. Serious exist concerning wavelength sensitivity dose-response photo-fragmentation process. Given heterogeneity natural irradiance varying from no sediments full floating, beach litter air-borne plastics, it argued that rates degradation/fragmentation will also vary dramatically between different locations environmental niches. Biological phenomena such as biofouling further modulate radiation, while potentially contributing and/or independent UVR. Reductions UVR many regions, consequent implementation Montreal Protocol its Amendments protecting stratospheric ozone, have consequences global heterogeneous manner across geographic zones. interacting effects warming, ozone are projected increase at surface localized areas, mainly because decreased cloud cover. complexity uncertainty future conditions, this currently precludes reliable predictions persistence on scale.

Язык: Английский

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Defense potential of secondary metabolites in medicinal plants under UV-B stress

Journal of Photochemistry and Photobiology B Biology, Год журнала: 2019, Номер 193, С. 51 - 88

Опубликована: Фев. 13, 2019

Язык: Английский

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Human health in relation to exposure to solar ultraviolet radiation under changing stratospheric ozone and climate

Photochemical & Photobiological Sciences, Год журнала: 2019, Номер 18(3), С. 641 - 680

Опубликована: Фев. 27, 2019

Язык: Английский

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Modulation of Phytohormone Signaling: A Primary Function of Flavonoids in Plant–Environment Interactions

Frontiers in Plant Science, Год журнала: 2018, Номер 9

Опубликована: Июль 20, 2018

The old observation that plants preferentially synthesize flavonoids with respect to the wide range of phenylpropanoid structures when exposed high doses UV-B radiation has supported view are primarily involved in absorbing shortest solar wavelengths photoprotection. However, there is compelling evidence biosynthesis similarly upregulated response photosynthetically active presence or absence UV-radiation, as well excess metal ions and photosynthetic redox unbalance. This supports hypothesis may play prominent roles scavengers reactive oxygen species (ROS) generated by light excess. These 'antioxidant' functions appears robust, maintained between different life kingdoms, e.g., animals. ability buffer stress-induced large alterations ROS homeostasis and, hence, modulate ROS-signaling cascade, at base well-known developmental regulators both There long very recent indeed that, plants, strongly affect phytohormone signaling, auxin abscisic acid signaling. function served a low (nM) concentration involves inhibit activity protein kinases, including but not limited mitogen-activated operate downstream regulation cell growth differentiation. For example, transport acting on serine-threonine PINOID (PID) kinases regulate localization efflux facilitators PIN-formed (PIN) proteins. Flavonoids also determine gradients cellular tissue levels, consequential processes, reducing catabolism. Recent observations lead regulation/modulation transport/signaling likely an ancestral flavonoids. antagonistic ABA-induced stomatal closure offer novel hypotheses functional role plant-environment interactions, early modern terrestrial plants. Here, we surmise signaling might have represented primary flavonols for conquest land it still major significance successful acclimation severe radiant energy.

Язык: Английский

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Environmental effects of stratospheric ozone depletion, UV radiation, and interactions with climate change: UNEP Environmental Effects Assessment Panel, Update 2020

Photochemical & Photobiological Sciences, Год журнала: 2021, Номер 20(1), С. 1 - 67

Опубликована: Янв. 1, 2021

Abstract This assessment by the Environmental Effects Assessment Panel (EEAP) of United Nations Environment Programme (UNEP) provides latest scientific update since our most recent comprehensive (Photochemical and Photobiological Sciences, 2019, 18, 595–828). The interactive effects between stratospheric ozone layer, solar ultraviolet (UV) radiation, climate change are presented within framework Montreal Protocol Sustainable Development Goals. We address how these global environmental changes affect atmosphere air quality; human health; terrestrial aquatic ecosystems; biogeochemical cycles; materials used in outdoor construction, energy technologies, fabrics. In many cases, there is a growing influence from seasonality extreme events due to change. Additionally, we assess transmission severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which responsible for COVID-19 pandemic, context linkages with UV radiation Protocol.

Язык: Английский

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Impact of climate change and anthropogenic activities on aquatic ecosystem – A review

Environmental Research, Год журнала: 2023, Номер 238, С. 117233 - 117233

Опубликована: Окт. 2, 2023

Язык: Английский

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Sunscreen photoprotection and vitamin D status

British Journal of Dermatology, Год журнала: 2019, Номер 181(5), С. 916 - 931

Опубликована: Май 9, 2019

Global concern about vitamin D deficiency has fuelled debates on photoprotection and the importance of solar exposure to meet requirements. To review published evidence reach a consensus influence by sunscreens status, considering other relevant factors. An international panel 13 experts in endocrinology, dermatology, photobiology, epidemiology biological anthropology reviewed literature prior 1‐day meeting June 2017, during which was discussed. Methods assessment determining factors public health perspectives were examined consequences sun effects assessed. A serum level ≥ 50 nmol L−1 25(OH)D is target for all individuals. Broad‐spectrum that prevent erythema are unlikely compromise status healthy populations. Vitamin screening should be restricted those at risk hypovitaminosis, such as patients with photosensitivity disorders, who require rigorous photoprotection. Screening supplementation advised this group. Sunscreen use daily recreational does not synthesis, even when applied under optimal conditions. What's already known topic? Knowledge relationship between behaviour, sunscreen important but there confusion safest way achieve this. Practical recommendations potential impact and/or lacking people. What study add? Judicious broad‐spectrum high ultraviolet (UV) protection will However, strategies disorders include sun‐protection factor UVA protection, along protective clothing shade‐seeking behaviour likely status. recommended disorders.

Язык: Английский

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Linkages between stratospheric ozone, UV radiation and climate change and their implications for terrestrial ecosystems

Photochemical & Photobiological Sciences, Год журнала: 2019, Номер 18(3), С. 681 - 716

Опубликована: Фев. 27, 2019

Язык: Английский

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