Materials,
Год журнала:
2021,
Номер
14(10), С. 2647 - 2647
Опубликована: Май 18, 2021
Porous
tantalum
(Ta)
is
a
promising
biomaterial
and
has
been
applied
in
orthopedics
dentistry
for
nearly
two
decades.
The
high
porosity
interconnected
pore
structure
of
porous
Ta
promise
fine
bone
ingrowth
new
formation
within
the
inner
space,
which
further
guarantee
rapid
osteointegration
bone-implant
stability
long
term.
wettability
surface
energy
that
can
facilitate
adherence,
proliferation
mineralization
osteoblasts.
Meanwhile,
low
elastic
modulus
friction
coefficient
allow
it
to
effectively
avoid
stress
shield
effect,
minimize
marginal
loss
ensure
primary
stability.
Accordingly,
satisfactory
clinical
application
Ta-based
implants
or
prostheses
mainly
derived
from
its
excellent
biological
mechanical
properties.
With
advent
additive
manufacturing,
personalized
have
shown
their
value
treatment
individual
patients
who
need
specially
designed
prosthesis.
In
addition,
many
modification
methods
introduced
enhance
bioactivity
antibacterial
property
with
vitro
vivo
research
results.
any
case,
choosing
suitable
great
importance
surgical
success
after
insertion.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Год журнала:
2021,
Номер
119, С. 104495 - 104495
Bioactive Materials,
Год журнала:
2021,
Номер
6(10), С. 3254 - 3268
Опубликована: Март 14, 2021
Vascularization
and
bone
regeneration
are
two
closely
related
processes
during
reconstruction.
A
three-dimensional
(3D)
scaffold
with
porous
architecture
provides
a
suitable
microenvironment
for
vascular
growth
formation.
Here,
we
present
simple
general
strategy
to
construct
nanofibrous
poly(l-lactide)/poly(ε-caprolactone)
(PLLA/PCL)
interconnected
perfusable
microchannel
networks
(IPMs)
based
on
3D
printing
technology
by
combining
the
phase
separation
sacrificial
template
methods.
The
regular
customizable
patterns
within
scaffolds
(spacings:
0.4
mm,
0.5
0.6
mm;
diameters:
0.8
1
1.2
mm)
were
made
investigate
effect
of
structure
angiogenesis
osteogenesis.
results
subcutaneous
embedding
experiment
showed
that
0.5/0.8-IPMs
(spacing/diameter
=
0.5/0.8)
0.5/1-IPMs
0.5/1)
exhibited
more
network
formation
as
compared
other
counterparts.
After
loading
endothelial
factor
(VEGF),
[email
protected]/0.8
prompted
better
human
umbilical
vein
cells
(HUVECs)
migration
neo-blood
vessel
formation,
determined
Transwell
migration,
scratch
wound
healing,
chorioallantoic
membrane
(CAM)
assays.
Furthermore,
microangiography
rat
cranial
defects
experiments
demonstrated
performance
in
new
protected]/1
scaffold.
In
summary,
our
suggested
could
be
tailored
an
adjustable
caramel-based
strategy,
combination
perfusion
angiogenic
factors
significantly
enhance
vascularization
regeneration.
Life,
Год журнала:
2022,
Номер
12(6), С. 903 - 903
Опубликована: Июнь 16, 2022
Trauma
and
bone
loss
from
infections,
tumors,
congenital
diseases
make
repair
regeneration
the
greatest
challenges
in
orthopedic,
craniofacial,
plastic
surgeries.
The
shortage
of
donors,
intrinsic
limitations,
complications
transplantation
have
led
to
more
focus
interest
regenerative
medicine.
Structures
that
closely
mimic
tissue
can
be
produced
by
this
unique
technology.
steady
development
three-dimensional
(3D)-printed
engineering
scaffold
therapy
has
played
an
important
role
achieving
desired
goal.
Bioceramic
scaffolds
are
widely
studied
appear
most
promising
solution.
In
addition,
3D
printing
technology
simulate
mechanical
biological
surface
properties
print
with
high
precision
complex
internal
external
structures
match
their
functional
properties.
Inkjet,
extrusion,
light-based
among
rapidly
advancing
bioprinting
technologies.
Furthermore,
stem
cell
recently
shown
field,
although
large
defects
difficult
fill
injection
alone.
combination
3D-printed
cells
very
results.
Therefore,
biocompatible
artificial
living
is
key
element
required
for
clinical
applications
where
there
a
demand
defect
repair.
emergence
various
advanced
manufacturing
technologies
made
form
biomaterials
functions,
composition,
structure
diversified,
manifold.
importance
article
lies
it
aims
briefly
review
main
principles
characteristics
currently
available
methods
orthopedic
prepare
bioceramic
scaffolds,
finally
discuss
prospects
vital
field.
Materials,
Год журнала:
2022,
Номер
15(15), С. 5457 - 5457
Опубликована: Авг. 8, 2022
Additive
manufacturing
(AM,
also
known
as
3D
printing)
is
an
advanced
technique
that
has
enabled
progress
in
the
design
and
fabrication
of
customised
or
patient-specific
(meta-)biomaterials
biomedical
devices
(e.g.,
implants,
prosthetics,
orthotics)
with
complex
internal
microstructures
tuneable
properties.
In
past
few
decades,
several
guidelines
have
been
proposed
for
creating
porous
lattice
structures,
particularly
applications.
Meanwhile,
capabilities
AM
to
fabricate
a
wide
range
biomaterials,
including
metals
their
alloys,
polymers,
ceramics,
exploited,
offering
unprecedented
benefits
medical
professionals
patients
alike.
this
review
article,
we
provide
overview
principles
developed
used
biomaterials
well
those
dealing
three
major
categories
i.e.,
(and
alloys),
ceramics.
The
strategies
can
be
categorised
as:
library-based
design,
topology
optimisation,
bio-inspired
meta-biomaterials.
Recent
developments
related
applications
methods
aimed
at
enhancing
quality
final
3D-printed
improving
physical,
mechanical,
biological
characteristics
are
highlighted.
Finally,
examples
tuned
properties
functionalities
presented.
Materials,
Год журнала:
2021,
Номер
14(10), С. 2647 - 2647
Опубликована: Май 18, 2021
Porous
tantalum
(Ta)
is
a
promising
biomaterial
and
has
been
applied
in
orthopedics
dentistry
for
nearly
two
decades.
The
high
porosity
interconnected
pore
structure
of
porous
Ta
promise
fine
bone
ingrowth
new
formation
within
the
inner
space,
which
further
guarantee
rapid
osteointegration
bone-implant
stability
long
term.
wettability
surface
energy
that
can
facilitate
adherence,
proliferation
mineralization
osteoblasts.
Meanwhile,
low
elastic
modulus
friction
coefficient
allow
it
to
effectively
avoid
stress
shield
effect,
minimize
marginal
loss
ensure
primary
stability.
Accordingly,
satisfactory
clinical
application
Ta-based
implants
or
prostheses
mainly
derived
from
its
excellent
biological
mechanical
properties.
With
advent
additive
manufacturing,
personalized
have
shown
their
value
treatment
individual
patients
who
need
specially
designed
prosthesis.
In
addition,
many
modification
methods
introduced
enhance
bioactivity
antibacterial
property
with
vitro
vivo
research
results.
any
case,
choosing
suitable
great
importance
surgical
success
after
insertion.
