Early-Stage Lung Cancer Diagnosis by Deep Learning-Based Spectroscopic Analysis of Circulating Exosomes

ACS Nano, Год журнала: 2020, Номер 14(5), С. 5435 - 5444

Опубликована: Апрель 14, 2020

Lung cancer has a high mortality rate, but an early diagnosis can contribute to favorable prognosis. A liquid biopsy that captures and detects tumor-related biomarkers in body fluids great potential for early-stage diagnosis. Exosomes, nanosized extracellular vesicles found blood, have been proposed as promising biopsy. Here, we demonstrate accurate of lung cancer, using deep learning-based surface-enhanced Raman spectroscopy (SERS) the exosomes. Our approach was explore features cell exosomes through learning figure out similarity human plasma exosomes, without insufficient data. The model trained with SERS signals derived from normal lines could classify them accuracy 95%. In 43 patients, including stage I II predicted 90.7% patients had higher than average healthy controls. Such proportional progression cancer. Notably, area under curve (AUC) 0.912 whole cohort AUC 0.910. These results suggest combination exosome analysis method

Язык: Английский

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Mass spectrometry-based metabolomics in microbiome investigations

Nature Reviews Microbiology, Год журнала: 2021, Номер 20(3), С. 143 - 160

Опубликована: Сен. 22, 2021

Язык: Английский

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Correlation and association analyses in microbiome study integrating multiomics in health and disease

Progress in molecular biology and translational science, Год журнала: 2020, Номер unknown, С. 309 - 491

Опубликована: Янв. 1, 2020

Язык: Английский

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Methodology and applications of elemental mapping by laser induced breakdown spectroscopy

Analytica Chimica Acta, Год журнала: 2020, Номер 1147, С. 72 - 98

Опубликована: Дек. 30, 2020

In the last few years, LIBS has become an established technique for assessment of elemental concentrations in various sample types. However, many applications knowledge about overall composition is not sufficient. addition, detailed information distribution within a heterogeneous needed. great interest imaging studies, since this allows to associate obtained with spatial coordinates investigated sample. The possibility simultaneous multi-elemental analysis major, minor, and trace constituents almost all types solid materials no or negligible preparation combined high speed are benefits which make especially attractive when compared other techniques. first part review aimed at providing instrumental requirements necessary successful measurements points out discusses state-of-the-art instrumentation upcoming developments. second dedicated data processing evaluation data. This chapter focused on different approaches multivariate chemometrics can be used e.g. classification but also quantification final part, current literature ranging from bioimaging, geoscientific cultural heritage studies field science summarized reviewed.

Язык: Английский

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A Systematic Review on Monitoring and Advanced Control Strategies in Smart Agriculture

IEEE Access, Год журнала: 2021, Номер 9, С. 32517 - 32548

Опубликована: Янв. 1, 2021

Automation in agriculture nowadays is the main focus and area of development for various countries. The population rate world increasing rapidly will be double upcoming decades need food also accordingly. To meet this rapid growth demand, automation best solution. Traditional strategies employed by farmers are not efficient enough to fulfill rising demand. Improper use nutrients, water, fertilizers pesticides disturbs agricultural land remains barren with no fertility. This research paper presents different control used automate such as: IoT, aerial imagery, multispectral, hyperspectral, NIR, thermal camera, RGB machine learning, artificial intelligence techniques. Problems like plant diseases, pesticide control, weed management, irrigation water management can easily solved automated techniques mentioned above. advance methods have verified increase crops yield soil fertility become strong. reviews observe work researchers present a brief summary about trends smart provides flow revenue system figure 15 using technologies their papers.

Язык: Английский

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Polystyrene microplastics up-regulates liver glutamine and glutamate synthesis and promotes autophagy-dependent ferroptosis and apoptosis in the cerebellum through the liver-brain axis

Environmental Pollution, Год журнала: 2022, Номер 307, С. 119449 - 119449

Опубликована: Май 9, 2022

Язык: Английский

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Wekemo Bioincloud: A user‐friendly platform for meta‐omics data analyses

iMeta, Год журнала: 2024, Номер 3(1)

Опубликована: Фев. 1, 2024

The increasing application of meta-omics approaches to investigate the structure, function, and intercellular interactions microbial communities has led a surge in available data. However, this abundance human environmental microbiome data exposed new scalability challenges for existing bioinformatics tools. In response, we introduce Wekemo Bioincloud-a specialized platform -omics studies. This offers comprehensive analysis solution, specifically designed alleviate tool selection users face expanding sets. As now, Bioincloud been regularly equipped with 22 workflows 65 visualization tools, establishing itself as user-friendly widely embraced studying diverse Additionally, enables online modification vector outputs, registration-independent personalized dashboard system ensures privacy traceability. is freely at https://www.bioincloud.tech/.

Язык: Английский

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Current Application of Advancing Spectroscopy Techniques in Food Analysis: Data Handling with Chemometric Approaches

Foods, Год журнала: 2023, Номер 12(14), С. 2753 - 2753

Опубликована: Июль 19, 2023

In today’s era of increased food consumption, consumers have become more demanding in terms safety and the quality products they consume. As a result, authorities are closely monitoring industry to ensure that meet required standards quality. The analysis properties encompasses various aspects, including chemical physical descriptions, sensory assessments, authenticity, traceability, processing, crop production, storage conditions, microbial contaminant levels. Traditionally, has relied on conventional analytical techniques. However, these methods often involve destructive processes, which laborious, time-consuming, expensive, environmentally harmful. contrast, advanced spectroscopic techniques offer promising alternative. Spectroscopic such as hyperspectral multispectral imaging, NMR, Raman, IR, UV, visible, fluorescence, X-ray-based provide rapid, non-destructive, cost-effective, friendly means analysis. Nevertheless, interpreting spectroscopy data, whether form signals (fingerprints) or images, can be complex without assistance statistical innovative chemometric approaches. These approaches steps pre-processing, exploratory analysis, variable selection, regression, classification, data integration. They essential for extracting relevant information effectively handling complexity data. This review aims address, discuss, examine recent studies tools context product applications trends. Furthermore, it focuses practical aspects spectral handling, model construction, interpretation, general utilization both qualitative quantitative By exploring advancements their integration with tools, this provides valuable insights into potential future directions industry. It emphasizes importance efficient development, implementation field

Язык: Английский

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Distributed harmonic patterns of structure-function dependence orchestrate human consciousness

Communications Biology, Год журнала: 2023, Номер 6(1)

Опубликована: Янв. 28, 2023

Abstract A central question in neuroscience is how consciousness arises from the dynamic interplay of brain structure and function. Here we decompose functional MRI signals pathological pharmacologically-induced perturbations into distributed patterns structure-function dependence across scales: harmonic modes human structural connectome. We show that coupling a generalisable indicator under bi-directional neuromodulatory control. find increased scales during loss consciousness, whether due to anaesthesia or injury, capable discriminating between behaviourally indistinguishable sub-categories brain-injured patients, tracking presence covert consciousness. The opposite signature characterises altered state induced by LSD ketamine, reflecting psychedelic-induced decoupling function correlating with physiological subjective scores. Overall, connectome decomposition reveals neuromodulation network architecture jointly shape activation scales.

Язык: Английский

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Spectroscopic food adulteration detection using machine learning: Current challenges and future prospects

Trends in Food Science & Technology, Год журнала: 2024, Номер 146, С. 104377 - 104377

Опубликована: Фев. 12, 2024

Язык: Английский

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