Organic Letters,
Год журнала:
2022,
Номер
24(5), С. 1141 - 1145
Опубликована: Янв. 31, 2022
We
developed
rhodium-catalyzed
alkoxylcarbonylation/acylation
of
indolines
using
anhydrides
as
a
safe
and
easy-to-handle
carbonyl
source.
This
catalytic
process
represents
an
additive-
CO-free
carbonylation,
establishing
simple
straightforward
protocol
for
synthesizing
C7-carbonylated
indolines.
Notably,
this
reaction
provides
successful
example
C-H
acylation
that
results
in
the
formation
α-branched
ketones,
which
were
difficult
to
prepare
by
previously
reported
analogous
reactions.
Organic Letters,
Год журнала:
2022,
Номер
24(32), С. 6000 - 6005
Опубликована: Авг. 10, 2022
A
Rh-catalyzed
weak
chelation-guided
C4-alkylation
of
indoles
has
been
accomplished
using
cyclopropanols
as
an
alkylating
agent
via
the
cascade
C–H
and
C–C
bond
activation.
The
substrate
scope,
functional
group
tolerance,
late-stage
mutation
drug
molecules
are
important
practical
features.
Organic Letters,
Год журнала:
2024,
Номер
26(18), С. 3685 - 3690
Опубликована: Янв. 29, 2024
An
efficient
palladium-catalyzed
region-selective
C7-trifluoromethylation
of
indolines
using
commercially
available
Umemoto's
reagent
was
reported.
The
reaction
utilizing
as
CF
Organic Letters,
Год журнала:
2019,
Номер
21(24), С. 9898 - 9903
Опубликована: Дек. 3, 2019
A
weak
carbonyl
coordination-guided
regioselective
C4
allylation
of
indoles
is
demonstrated
using
the
versatile
Morita–Baylis–Hillman
adduct
in
presence
Rh
catalysts
a
redox-neutral
fashion.
The
substrate
scope,
functional
group
diversity,
oxidant
free
character,
mechanistic
aspects,
and
synthetic
utilities
are
important
practical
features.
