Advanced Materials,
Год журнала:
2019,
Номер
32(3)
Опубликована: Март 29, 2019
Abstract
On
the
basis
of
Jablonski
diagram,
photophysical
properties
optical
agents
are
highly
associated
with
biomedical
function
and
efficacy.
Herein,
focus
is
on
organic/polymer
recent
progress
in
main
strategies
for
regulating
their
to
achieve
superior
cancer
diagnosis/phototheranostics
applications
highlighted.
Both
approaches
nanoengineering
molecular
design,
which
can
lead
optimized
effectiveness
required
function,
discussed.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Май 18, 2021
Abstract
Immunometabolic
intervention
has
been
applied
to
treat
cancer
via
inhibition
of
certain
enzymes
associated
with
intratumoral
metabolism.
However,
small-molecule
inhibitors
and
genetic
modification
often
suffer
from
insufficiency
off-target
side
effects.
Proteolysis
targeting
chimeras
(PROTACs)
provide
an
alternative
way
modulate
protein
homeostasis
for
therapy;
however,
the
always-on
bioactivity
existing
PROTACs
potentially
leads
uncontrollable
degradation
at
non-target
sites,
limiting
their
in
vivo
therapeutic
efficacy.
We
herein
report
a
semiconducting
polymer
nano-PROTAC
(SPN
pro
)
phototherapeutic
activatable
abilities
photo-immunometabolic
therapy.
SPN
can
remotely
generate
singlet
oxygen
(
1
O
2
under
NIR
photoirradiation
eradicate
tumor
cells
induce
immunogenic
cell
death
(ICD)
enhance
immunogenicity.
Moreover,
PROTAC
function
is
specifically
activated
by
biomarker
(cathepsin
B)
trigger
targeted
proteolysis
immunosuppressive
indoleamine
2,3-dioxygenase
(IDO)
living
mice.
The
persistent
IDO
blocks
tryptophan
(Trp)-catabolism
program
promotes
activation
effector
T
cells.
Such
SPNpro-mediated
in-situ
immunometabolic
synergizes
phototherapy
boost
antitumor
T-cell
immunity,
effectively
inhibiting
growth
metastasis.
Thus,
this
study
provides
platform
advance
Advanced Materials,
Год журнала:
2021,
Номер
33(43)
Опубликована: Сен. 12, 2021
Abstract
Cancer
has
been
one
of
the
most
common
life‐threatening
diseases
for
a
long
time.
Traditional
cancer
therapies
such
as
surgery,
chemotherapy
(CT),
and
radiotherapy
(RT)
have
limited
effects
due
to
drug
resistance,
unsatisfactory
treatment
efficiency,
side
effects.
In
recent
years,
photodynamic
therapy
(PDT),
photothermal
(PTT),
chemodynamic
(CDT)
utilized
owing
their
high
selectivity,
minor
minimal
toxicity.
Accumulating
evidence
demonstrated
that
selective
delivery
drugs
specific
subcellular
organelles
can
significantly
enhance
efficiency
therapy.
Mitochondria‐targeting
therapeutic
strategies
are
promising
therapy,
which
is
attributed
essential
role
mitochondria
in
regulation
cell
apoptosis,
metabolism,
more
vulnerable
hyperthermia
oxidative
damage.
Herein,
rational
design,
functionalization,
applications
diverse
mitochondria‐targeting
units,
involving
organic
phosphine/sulfur
salts,
quaternary
ammonium
(QA)
peptides,
transition‐metal
complexes,
guanidinium
or
bisguanidinium,
well
including
PDT,
PTT,
CDT,
others
summarized.
This
review
aims
furnish
researchers
with
deep
insights
hints
design
novel
agents
Advanced Materials,
Год журнала:
2019,
Номер
31(11)
Опубликована: Янв. 21, 2019
Photoacoustic
(PA)
imaging
in
the
second
near-infrared
(NIR-II)
window
(1000-1700
nm)
holds
great
promise
for
deep-tissue
diagnosis
due
to
reduced
light
scattering
and
minimized
tissue
absorption;
however,
exploration
of
such
a
noninvasive
technique
is
greatly
constrained
by
lack
biodegradable
NIR-II
absorbing
agents.
Herein,
first
series
metabolizable
PA
agents
are
reported
based
on
semiconducting
polymer
nanoparticles
(SPNs).
Such
completely
organic
nanoagents
consist
π-conjugated
yet
oxidizable
optical
as
generator
hydrolyzable
amphiphilic
particle
matrix
provide
water
solubility.
The
obtained
SPNs
readily
degraded
myeloperoxidase
lipase
abundant
phagocytes,
transforming
from
nonfluorescent
(30
into
NIR
fluorescent
ultrasmall
metabolites
(≈1
nm).
As
such,
these
can
be
effectively
cleared
out
via
both
hepatobiliary
renal
excretions
after
systematic
administration,
leaving
no
toxicity
living
mice.
Particularly
possess
high
photothermal
conversion
efficiencies
emit
bright
signals
at
1064
nm,
enabling
sensitive
subcutaneous
tumor
deep
brain
vasculature
through
intact
skull
animals
low
dosage.
This
study
thus
provides
generalized
molecular
design
toward
materials
biophotonic
applications
window.
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Июнь 18, 2020
Real-time
monitoring
of
vessel
dysfunction
is
great
significance
in
preclinical
research.
Optical
bioimaging
the
second
near-infrared
(NIR-II)
window
provides
advantages
including
high
resolution
and
fast
feedback.
However,
reported
molecular
dyes
are
hampered
by
limited
blood
circulation
time
(~
5-60
min)
short
absorption
emission
wavelength,
which
impede
accurate
long-term
monitoring.
Here,
we
report
a
NIR-II
molecule
(LZ-1105)
with
beyond
1000
nm.
Thanks
to
long
(half-life
3.2
h),
fluorophore
used
for
continuous
real-time
dynamic
vascular
processes,
ischemic
reperfusion
hindlimbs,
thrombolysis
carotid
artery
opening
recovery
brain
barrier
(BBB).
LZ-1105
an
approach
researchers
assess
due
excitation
wavelength
properties.
Advanced Materials,
Год журнала:
2019,
Номер
32(3)
Опубликована: Март 29, 2019
Abstract
On
the
basis
of
Jablonski
diagram,
photophysical
properties
optical
agents
are
highly
associated
with
biomedical
function
and
efficacy.
Herein,
focus
is
on
organic/polymer
recent
progress
in
main
strategies
for
regulating
their
to
achieve
superior
cancer
diagnosis/phototheranostics
applications
highlighted.
Both
approaches
nanoengineering
molecular
design,
which
can
lead
optimized
effectiveness
required
function,
discussed.
