Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Авг. 2, 2022
Abstract
Bacteria-based
tumor
therapy
has
recently
attracted
wide
attentions
due
to
its
unique
capability
in
targeting
tumors
and
preferentially
colonizing
the
core
area
of
tumor.
Various
therapeutic
genes
are
also
harbored
into
these
engineering
bacteria
enhance
their
anti-tumor
efficacy.
However,
it
is
difficult
spatiotemporally
control
expression
inserted
site.
Here,
we
engineer
an
ultrasound-responsive
bacterium
(URB)
which
can
induce
exogenous
ultrasound-controllable
manner.
Owing
advantage
ultrasound
tissue
penetration,
acoustic
remote
bacterial
gene
be
realized
by
designing
a
temperature-actuated
genetic
switch.
Cytokine
interferon-γ
(IFN-γ),
important
immune
regulatory
molecule
that
plays
significant
role
immunotherapy,
used
test
system.
Our
results
show
brief
hyperthermia
induced
focused
promotes
IFN-γ
gene,
improving
efficacy
URB
vitro
vivo.
study
provides
alternative
strategy
for
bacteria-mediated
immunotherapy.
Science Translational Medicine,
Год журнала:
2021,
Номер
13(599)
Опубликована: Июнь 23, 2021
The
restoration
of
tumor
suppressor
PTEN
by
synthetic
mRNA
nanoparticles
sensitizes
Pten
-null
or
mutated
tumors
to
immune
checkpoint
blockade
therapy.
Angewandte Chemie International Edition,
Год журнала:
2020,
Номер
60(8), С. 3858 - 3869
Опубликована: Авг. 13, 2020
Molecularly
imprinted
polymers
(MIPs)
are
chemically
synthesized
affinity
materials
with
tailor-made
binding
cavities
complementary
to
the
template
molecules
in
shape,
size,
and
functionality.
Recently,
engineering
MIP-based
nanomedicines
improve
cancer
therapy
has
become
a
rapidly
growing
field
future
research
direction.
Because
of
unique
properties
functions
MIPs,
nanoparticles
(nanoMIPs)
not
only
alternatives
current
nanomaterials
for
therapy,
but
also
hold
potential
fill
gaps
associated
biological
ligand-based
nanomedicines,
such
as
immunogenicity,
stability,
applicability,
economic
viability.
Here,
we
survey
recent
advances
design
fabrication
nanoMIPs
highlight
their
distinct
features.
In
addition,
how
use
these
features
achieve
desired
performance,
including
extended
circulation,
active
targeting,
controlled
drug
release
anti-tumor
efficacy,
is
discussed
summarized.
We
expect
that
this
minireview
will
inspire
more
advanced
studies
therapy.
Acta Pharmaceutica Sinica B,
Год журнала:
2020,
Номер
11(4), С. 941 - 960
Опубликована: Дек. 31, 2020
The
initiation
and
development
of
major
inflammatory
diseases,
i.e.,
cancer,
vascular
inflammation,
some
autoimmune
diseases
are
closely
linked
to
the
immune
system.
Biologics-based
immunotherapy
is
exerting
a
critical
role
against
these
whereas
usage
immunomodulators
always
limited
by
various
factors
such
as
susceptibility
digestion
enzymes
in
vivo,
poor
penetration
across
biological
barriers,
rapid
clearance
reticuloendothelial
Drug
delivery
strategies
potent
promote
their
delivery.
Herein,
we
reviewed
potential
targets
for
discussed
biologics
drug
systems
involved
immunotherapy,
particularly
highlighted
approved
therapy
tactics,
finally
offer
perspectives
this
field.
Advanced Materials,
Год журнала:
2020,
Номер
32(16)
Опубликована: Март 3, 2020
Abstract
Necroptosis,
caspase‐independent
programmed
necrosis,
has
emerged
as
a
therapeutic
target
to
make
dying
cancer
cells
stimulants
for
antitumor
immune
responses.
The
clinical
translations
exploiting
necroptosis,
however,
have
been
limited
since
most
downregulate
receptor‐interacting
protein
kinase
3
(RIPK3)
key
enzyme
necroptosis.
Herein,
nanobubbles
(NBs)
that
can
trigger
RIPK3‐independent
facilitating
cell‐membrane
rupture
via
the
acoustic
cavitation
effect
are
reported.
NBs,
imbibing
perfluoropentane
gas
precursor,
prepared
using
an
amphiphilic
polymer
conjugate,
composed
of
PEGylated
carboxymethyl
dextran
hydrophilic
backbone
and
chlorin
e6
hydrophobic
sonosensitizer.
When
exposed
ultrasound,
NBs
efficiently
promote
release
biologically
active
damage‐associated
molecular
patterns
by
inducing
burst‐mediated
disintegration.
Consequently,
necroptosis‐inducible
significantly
improve
immunity
maturation
dendritic
activation
CD8
+
cytotoxic
T
both
in
vitro
vivo.
In
addition,
combination
checkpoint
blockade
leads
complete
regression
primary
tumor
beneficial
activity
against
metastatic
tumors
RIPK3‐deficient
CT26
tumor‐bearing
mouse
model.
Overall,
innovative
NB
causes
immunogenic
cell
death
necroptosis
is
promising
enhancer
immunotherapy.
Theranostics,
Год журнала:
2022,
Номер
13(1), С. 295 - 323
Опубликована: Дек. 19, 2022
Cancer
remains
a
severe
threat
to
human
health.
To
date,
although
various
therapeutic
methods,
including
radiotherapy
(RT),
chemotherapy,
chemodynamic
therapy
(CDT),
phototherapy,
starvation
therapy,
and
immunotherapy,
have
entered
new
stage
of
rapid
progress
in
cancer
theranostics,
their
limited
effect
significant
side
effects
need
be
considered
carefully.
With
the
development
nanotechnology,
marriage
nanomaterials
methods
provides
practical
possibility
improve
deficiencies
therapy.
Notably,
metal-organic
frameworks
(MOFs)
composed
ions/clusters
bridging
ligands
through
coordination
bonds
been
widely
applied
deal
with
drawbacks
different
such
as
effects,
low
stability,
poor
efficacy,
owing
controllable
morphologies,
tailorable
diameters,
diverse
compositions,
tunable
porosities,
high
specific
surface
areas,
facile
functionalization,
good
biocompatibility.
This
review
summarizes
recent
advanced
developments
achievements
multifunctional
MOF-based
nanoplatforms
for
single
RT,
CDT,
phototherapy
(photodynamic
photothermal
therapy),
combination
methods.
Moreover,
prospects
challenges
used
tumor
are
also
discussed.
ACS Nano,
Год журнала:
2020,
Номер
14(12), С. 17100 - 17113
Опубликована: Ноя. 25, 2020
Self-delivery
of
photosensitizer
and
immune
modulator
to
tumor
site
is
highly
recommendable
improve
the
photodynamic
immunotherapy
yet
remains
challenging.
Herein,
self-delivery
photoimmune
stimulators
(designated
as
iPSs)
are
developed
for
sensitized
immunotherapy.
Carrier-free
iPSs
constructed
by
optimizing
noncovalent
interactions
between
pure
drugs
chlorine
e6
(Ce6)
NLG919,
which
avoid
excipients-raised
toxicity
immunogenicity.
Intravenously
administrated
prefer
passively
accumulate
on
tissues
a
robust
therapy
(PDT)
with
induction
immunogenetic
cell
death
(ICD)
cascade
activate
cytotoxic
T
lymphocytes
(CTLs)
initiate
antitumor
response.
Meanwhile,
concomitant
delivery
NLG919
inhibits
activation
indoleamine
2,3-dioxygenase
1
(IDO-1)
reverse
immunosuppressive
microenvironment.
Ultimately,
efficiently
inhibit
primary
distant
growth
low
system
toxicity,
would
shed
light
development
nanomedicine
clinical
transformation
in
precision
therapy.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Янв. 1, 2024
Abstract
Combining
existing
drug
therapy
is
essential
in
developing
new
therapeutic
agents
disease
prevention
and
treatment.
In
preclinical
investigations,
combined
effect
of
certain
known
drugs
has
been
well
established
treating
extensive
human
diseases.
Attributed
to
synergistic
effects
by
targeting
various
pathways
advantages,
such
as
reduced
administration
dose,
decreased
toxicity,
alleviated
resistance,
combinatorial
treatment
now
being
pursued
delivering
combat
major
clinical
illnesses,
cancer,
atherosclerosis,
pulmonary
hypertension,
myocarditis,
rheumatoid
arthritis,
inflammatory
bowel
disease,
metabolic
disorders
neurodegenerative
Combinatorial
involves
combining
or
co-delivering
two
more
for
a
specific
disease.
Nanoparticle
(NP)-mediated
delivery
systems,
i.e.,
liposomal
NPs,
polymeric
NPs
nanocrystals,
are
great
interest
wide
range
due
targeted
delivery,
extended
release,
higher
stability
avoid
rapid
clearance
at
infected
areas.
This
review
summarizes
targets
diseases,
clinically
approved
combinations
the
development
multifunctional
emphasizes
strategies
based
on
severe
Ultimately,
we
discuss
challenging
NP-codelivery
translation
provide
potential
approaches
address
limitations.
offers
comprehensive
overview
recent
cutting-edge
NP-mediated
combination
Advanced Materials,
Год журнала:
2023,
Номер
35(33)
Опубликована: Март 7, 2023
Abstract
Immunotherapy
has
made
remarkable
strides
in
cancer
therapy
over
the
past
decade.
However,
such
emerging
still
suffers
from
low
response
rates
and
immune‐related
adverse
events.
Various
strategies
have
been
developed
to
overcome
these
serious
challenges.
Therein,
sonodynamic
(SDT),
as
a
non‐invasive
treatment,
received
ever‐increasing
attention
especially
treatment
of
deep‐seated
tumors.
Significantly,
SDT
can
effectively
induce
immunogenic
cell
death
trigger
systemic
anti‐tumor
immune
response,
termed
immunotherapy.
The
rapid
development
nanotechnology
revolutionized
effects
with
robust
induction.
As
result,
more
innovative
nanosonosensitizers
synergistic
modalities
are
established
superior
efficacy
safe
profile.
In
this
review,
recent
advances
immunotherapy
summarized
particular
emphasis
on
how
be
explored
harness
for
amplifying
response.
Moreover,
current
challenges
field
prospects
its
clinical
translation
also
presented.
It
is
anticipated
that
review
provide
rational
guidance
facilitate
nanomaterials‐assisted
immunotherapy,
helping
pave
way
next‐generation
eventually
achieve
durable
patients.
Journal of Materials Chemistry B,
Год журнала:
2021,
Номер
9(22), С. 4459 - 4474
Опубликована: Янв. 1, 2021
In
the
presented
perspective,
synthetic
method,
characterization,
and
research
progress
in
tumor
therapy
based
on
CMMs
have
been
summarized.
Also
prospects
challenges
of
utilizing
for
discussed.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(12), С. 5136 - 5174
Опубликована: Янв. 1, 2022
Recent
years
have
witnessed
increasingly
rapid
advances
in
nanocarrier-based
biomedicine
aimed
at
improving
treatment
paradigms
for
cancer.
Nanogels
serve
as
multipurpose
and
constructed
vectors
formed
via
intramolecular
cross-linking
to
generate
drug
delivery
systems,
which
is
attributed
predominantly
their
satisfactory
biocompatibility,
bio-responsiveness,
high
stability,
low
toxicity.
Recently,
immunotherapy
has
experienced
unprecedented
growth
become
the
preferred
strategy
cancer
treatment,
mainly
involves
mobilisation
of
immune
system
an
enhanced
anti-tumour
immunity
tumour
microenvironment.
Despite
inspiring
success,
immunotherapeutic
strategies
are
limited
due
response
rates
immune-related
adverse
events.
Like
other
nanomedicines,
nanogels
comparably
by
lower
focal
enrichment
upon
introduction
into
organism
injection.
Because
three-dimensional
cross-linked
aqueous
materials
that
exhibit
similar
properties
natural
tissues
structurally
stable,
they
can
comfortably
cope
with
shear
forces
serum
proteins
bloodstream,
longer
circulation
life
increases
chance
nanogel
accumulation
tumour,
conferring
deep
penetration.
The
large
specific
surface
area
reduce
or
eliminate
off-target
effects
introducing
stimuli-responsive
functional
groups,
allowing
multiple
physical
chemical
modifications
purposes
improve
targeting
cell
subpopulations
organs,
increasing
bioavailability
drug,
a
events
on
therapies.
slow
release
reaching
site
facilitates
long-term
awakening
host's
system,
ultimately
achieving
therapeutic
effects.
As
effective
candidate
immunotherapy,
nanogel-based
been
widely
used.
In
this
review,
we
summarize
recent
deliver
immunomodulatory
small
molecule
drugs,
antibodies,
genes
cytokines,
target
antigen
presenting
cells,
form
vaccines,
enable
chimeric
receptor
(CAR)-T
therapy.
Future
challenges
well
expected
feasible
prospects
clinical
also
highlighted.