Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models

Science Translational Medicine, Год журнала: 2021, Номер 13(599)

Опубликована: Июнь 23, 2021

The restoration of tumor suppressor PTEN by synthetic mRNA nanoparticles sensitizes Pten -null or mutated tumors to immune checkpoint blockade therapy.

Язык: Английский

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Molecularly Imprinted Polymer Nanoparticles: An Emerging Versatile Platform for Cancer Therapy

Angewandte Chemie International Edition, Год журнала: 2020, Номер 60(8), С. 3858 - 3869

Опубликована: Авг. 13, 2020

Molecularly imprinted polymers (MIPs) are chemically synthesized affinity materials with tailor-made binding cavities complementary to the template molecules in shape, size, and functionality. Recently, engineering MIP-based nanomedicines improve cancer therapy has become a rapidly growing field future research direction. Because of unique properties functions MIPs, nanoparticles (nanoMIPs) not only alternatives current nanomaterials for therapy, but also hold potential fill gaps associated biological ligand-based nanomedicines, such as immunogenicity, stability, applicability, economic viability. Here, we survey recent advances design fabrication nanoMIPs highlight their distinct features. In addition, how use these features achieve desired performance, including extended circulation, active targeting, controlled drug release anti-tumor efficacy, is discussed summarized. We expect that this minireview will inspire more advanced studies therapy.

Язык: Английский

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Biological drug and drug delivery-mediated immunotherapy

Acta Pharmaceutica Sinica B, Год журнала: 2020, Номер 11(4), С. 941 - 960

Опубликована: Дек. 31, 2020

The initiation and development of major inflammatory diseases, i.e., cancer, vascular inflammation, some autoimmune diseases are closely linked to the immune system. Biologics-based immunotherapy is exerting a critical role against these whereas usage immunomodulators always limited by various factors such as susceptibility digestion enzymes in vivo, poor penetration across biological barriers, rapid clearance reticuloendothelial Drug delivery strategies potent promote their delivery. Herein, we reviewed potential targets for discussed biologics drug systems involved immunotherapy, particularly highlighted approved therapy tactics, finally offer perspectives this field.

Язык: Английский

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Necroptosis‐Inducible Polymeric Nanobubbles for Enhanced Cancer Sonoimmunotherapy

Advanced Materials, Год журнала: 2020, Номер 32(16)

Опубликована: Март 3, 2020

Abstract Necroptosis, caspase‐independent programmed necrosis, has emerged as a therapeutic target to make dying cancer cells stimulants for antitumor immune responses. The clinical translations exploiting necroptosis, however, have been limited since most downregulate receptor‐interacting protein kinase 3 (RIPK3) key enzyme necroptosis. Herein, nanobubbles (NBs) that can trigger RIPK3‐independent facilitating cell‐membrane rupture via the acoustic cavitation effect are reported. NBs, imbibing perfluoropentane gas precursor, prepared using an amphiphilic polymer conjugate, composed of PEGylated carboxymethyl dextran hydrophilic backbone and chlorin e6 hydrophobic sonosensitizer. When exposed ultrasound, NBs efficiently promote release biologically active damage‐associated molecular patterns by inducing burst‐mediated disintegration. Consequently, necroptosis‐inducible significantly improve immunity maturation dendritic activation CD8 + cytotoxic T both in vitro vivo. In addition, combination checkpoint blockade leads complete regression primary tumor beneficial activity against metastatic tumors RIPK3‐deficient CT26 tumor‐bearing mouse model. Overall, innovative NB causes immunogenic cell death necroptosis is promising enhancer immunotherapy.

Язык: Английский

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Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy

Theranostics, Год журнала: 2022, Номер 13(1), С. 295 - 323

Опубликована: Дек. 19, 2022

Cancer remains a severe threat to human health. To date, although various therapeutic methods, including radiotherapy (RT), chemotherapy, chemodynamic therapy (CDT), phototherapy, starvation therapy, and immunotherapy, have entered new stage of rapid progress in cancer theranostics, their limited effect significant side effects need be considered carefully. With the development nanotechnology, marriage nanomaterials methods provides practical possibility improve deficiencies therapy. Notably, metal-organic frameworks (MOFs) composed ions/clusters bridging ligands through coordination bonds been widely applied deal with drawbacks different such as effects, low stability, poor efficacy, owing controllable morphologies, tailorable diameters, diverse compositions, tunable porosities, high specific surface areas, facile functionalization, good biocompatibility. This review summarizes recent advanced developments achievements multifunctional MOF-based nanoplatforms for single RT, CDT, phototherapy (photodynamic photothermal therapy), combination methods. Moreover, prospects challenges used tumor are also discussed.

Язык: Английский

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Self-Delivery Photo-Immune Stimulators for Photodynamic Sensitized Tumor Immunotherapy

ACS Nano, Год журнала: 2020, Номер 14(12), С. 17100 - 17113

Опубликована: Ноя. 25, 2020

Self-delivery of photosensitizer and immune modulator to tumor site is highly recommendable improve the photodynamic immunotherapy yet remains challenging. Herein, self-delivery photoimmune stimulators (designated as iPSs) are developed for sensitized immunotherapy. Carrier-free iPSs constructed by optimizing noncovalent interactions between pure drugs chlorine e6 (Ce6) NLG919, which avoid excipients-raised toxicity immunogenicity. Intravenously administrated prefer passively accumulate on tissues a robust therapy (PDT) with induction immunogenetic cell death (ICD) cascade activate cytotoxic T lymphocytes (CTLs) initiate antitumor response. Meanwhile, concomitant delivery NLG919 inhibits activation indoleamine 2,3-dioxygenase 1 (IDO-1) reverse immunosuppressive microenvironment. Ultimately, efficiently inhibit primary distant growth low system toxicity, would shed light development nanomedicine clinical transformation in precision therapy.

Язык: Английский

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Multifunctional nanoparticle-mediated combining therapy for human diseases

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Янв. 1, 2024

Abstract Combining existing drug therapy is essential in developing new therapeutic agents disease prevention and treatment. In preclinical investigations, combined effect of certain known drugs has been well established treating extensive human diseases. Attributed to synergistic effects by targeting various pathways advantages, such as reduced administration dose, decreased toxicity, alleviated resistance, combinatorial treatment now being pursued delivering combat major clinical illnesses, cancer, atherosclerosis, pulmonary hypertension, myocarditis, rheumatoid arthritis, inflammatory bowel disease, metabolic disorders neurodegenerative Combinatorial involves combining or co-delivering two more for a specific disease. Nanoparticle (NP)-mediated delivery systems, i.e., liposomal NPs, polymeric NPs nanocrystals, are great interest wide range due targeted delivery, extended release, higher stability avoid rapid clearance at infected areas. This review summarizes targets diseases, clinically approved combinations the development multifunctional emphasizes strategies based on severe Ultimately, we discuss challenging NP-codelivery translation provide potential approaches address limitations. offers comprehensive overview recent cutting-edge NP-mediated combination

Язык: Английский

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Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 35(33)

Опубликована: Март 7, 2023

Abstract Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging still suffers from low response rates and immune‐related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic (SDT), as a non‐invasive treatment, received ever‐increasing attention especially treatment of deep‐seated tumors. Significantly, SDT can effectively induce immunogenic cell death trigger systemic anti‐tumor immune response, termed immunotherapy. The rapid development nanotechnology revolutionized effects with robust induction. As result, more innovative nanosonosensitizers synergistic modalities are established superior efficacy safe profile. In this review, recent advances immunotherapy summarized particular emphasis on how be explored harness for amplifying response. Moreover, current challenges field prospects its clinical translation also presented. It is anticipated that review provide rational guidance facilitate nanomaterials‐assisted immunotherapy, helping pave way next‐generation eventually achieve durable patients.

Язык: Английский

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Recent advances in cell membrane coated metal–organic frameworks (MOFs) for tumor therapy

Journal of Materials Chemistry B, Год журнала: 2021, Номер 9(22), С. 4459 - 4474

Опубликована: Янв. 1, 2021

In the presented perspective, synthetic method, characterization, and research progress in tumor therapy based on CMMs have been summarized. Also prospects challenges of utilizing for discussed.

Язык: Английский

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Bioengineered nanogels for cancer immunotherapy

Chemical Society Reviews, Год журнала: 2022, Номер 51(12), С. 5136 - 5174

Опубликована: Янв. 1, 2022

Recent years have witnessed increasingly rapid advances in nanocarrier-based biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as multipurpose and constructed vectors formed via intramolecular cross-linking to generate drug delivery systems, which is attributed predominantly their satisfactory biocompatibility, bio-responsiveness, high stability, low toxicity. Recently, immunotherapy has experienced unprecedented growth become the preferred strategy cancer treatment, mainly involves mobilisation of immune system an enhanced anti-tumour immunity tumour microenvironment. Despite inspiring success, immunotherapeutic strategies are limited due response rates immune-related adverse events. Like other nanomedicines, nanogels comparably by lower focal enrichment upon introduction into organism injection. Because three-dimensional cross-linked aqueous materials that exhibit similar properties natural tissues structurally stable, they can comfortably cope with shear forces serum proteins bloodstream, longer circulation life increases chance nanogel accumulation tumour, conferring deep penetration. The large specific surface area reduce or eliminate off-target effects introducing stimuli-responsive functional groups, allowing multiple physical chemical modifications purposes improve targeting cell subpopulations organs, increasing bioavailability drug, a events on therapies. slow release reaching site facilitates long-term awakening host's system, ultimately achieving therapeutic effects. As effective candidate immunotherapy, nanogel-based been widely used. In this review, we summarize recent deliver immunomodulatory small molecule drugs, antibodies, genes cytokines, target antigen presenting cells, form vaccines, enable chimeric receptor (CAR)-T therapy. Future challenges well expected feasible prospects clinical also highlighted.

Язык: Английский

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