Materials & Design,
Год журнала:
2023,
Номер
233, С. 112231 - 112231
Опубликована: Авг. 9, 2023
Bacterial
infection
continues
to
be
one
of
the
biggest
threats
human
health.
The
therapeutic
effect
is
significantly
reduced
as
a
result
development
super-bacteria-resistant
bacteria
due
overuse
antibiotics
for
conventional
antimicrobial
treatment.
emergence
drug-resistant
makes
it
necessary
develop
new
treatments.
Following
successful
application
photothermal
therapy
in
field
oncology
treatment,
more
and
researchers
are
applying
treatments
achieving
important
results,
especially
treatment
bacterial
infections.
As
non-invasive
anti-infection
method,
has
advantages
broad-spectrum
properties,
short
period,
low
systemic
impact.
In
PTT,
efficacy
strongly
depends
on
different
laser
properties
choice
agents
(PTAs).
purpose
this
review
discuss
most
recent
developments
nanomaterials
that
antibacterial.
We
will
delve
into
principles
spectrum
PTAs
provide
summary
current
synthesis,
classification,
structural
features,
physicochemical
antibacterial
performance
research.
challenges
future
prospects
enhanced
cytotoxicity
investigated.
Abstract
Tumor
immunotherapy
is
only
effective
in
a
fraction
of
patients
due
to
low
response
rate
and
severe
side
effects,
these
challenges
clinics
can
be
addressed
through
induction
immunogenic
cell
death
(ICD).
ICD
elicited
from
many
antitumor
therapies
release
danger
associated
molecular
patterns
(DAMPs)
tumor‐associated
antigens
facilitate
maturation
dendritic
cells
(DCs)
infiltration
cytotoxic
T
lymphocytes
(CTLs).
The
process
reverse
the
tumor
immunosuppressive
microenvironment
improve
sensitivity
immunotherapy.
Nanostructure‐based
drug
delivery
systems
(NDDSs)
are
explored
induce
by
incorporating
therapeutic
molecules
for
chemotherapy,
photosensitizers
(PSs)
photodynamic
therapy
(PDT),
photothermal
conversion
agents
(PTT),
radiosensitizers
radiotherapy
(RT).
These
NDDSs
loaded
at
right
dose
place
time,
resulting
greater
effectiveness
lower
toxicity.
Immunotherapeutic
also
combined
with
achieve
synergic
effect
multi‐modality
approach.
In
this
review,
harnessed
load
multiple
PDT,
PTT,
RT
combination
promote
reduce
effects
cancer
treatment.
Advanced Materials,
Год журнала:
2020,
Номер
33(4)
Опубликована: Дек. 2, 2020
Abstract
The
past
decades
have
witnessed
hyperthermia
therapy
(HTT)
as
an
emerging
strategy
against
malignant
tumors.
Nanomaterial‐based
photothermal
(PTT)
and
magnetic
(MHT),
highly
effective
noninvasive
treatment
models,
offer
advantages
over
other
strategies
in
the
of
different
types
However,
both
PTT
MHT
cannot
completely
cure
cancer
due
to
recurrence
distal
metastasis.
In
recent
years,
immunotherapy
has
attracted
widespread
attention
owing
its
capability
activate
body's
own
natural
defense
identify,
attack,
eradicate
cells.
Significant
efforts
been
devoted
studying
activated
immune
responses
caused
by
hyperthermia‐ablated
this
article,
synergistic
mechanism
HTT
immunotherapy,
including
immunogenic
cell
death
reversal
immunosuppressive
tumor
microenvironment
is
discussed.
reports
combination
or
HTT‐based
multimodal
with
immunoadjuvant
exploitation,
checkpoint
blockade
therapy,
adoptive
cellular
are
summarized.
As
highlighted,
these
could
achieve
synergistically
enhanced
therapeutic
outcomes
primary
tumors
metastatic
lesions,
prevent
recurrence,
prolong
survival
period.
Finally,
current
challenges
prospective
developments
HTT‐synergized
also
reviewed.
ACS Nano,
Год журнала:
2019,
Номер
13(11), С. 13304 - 13316
Опубликована: Ноя. 5, 2019
Despite
the
excellent
photodynamic
and
photothermal
properties
of
organic
molecular
photosensitizers
(PSs)
agents
(PTAs),
such
as
porphyrin
naphthalocyanine,
their
poor
water
solubility
severely
impedes
biological
applications.
Covalent
frameworks
(COFs),
an
emerging
class
crystalline
porous
materials,
possess
free
active
end
groups
(bonding
defects)
large
inner
pores,
which
make
them
ideal
type
nanocarriers
for
loading
hydrophobic
PSs
PTAs
by
both
bonding
defect
functionalization
(BDF)
guest
encapsulation
approaches
to
obtain
multifunctional
nanomedicines
PDT/PTT
combination
therapy.
In
this
work,
we
report
a
nanoscale
COF
(NCOF)
prepared
via
facile
synthetic
approach
under
ambient
conditions.
Furthermore,
dual-modal
therapeutic
nanoagent,
VONc@COF-Por
(3),
is
successfully
fabricated
stepwise
BDF
processes.
The
covalently
grafted
porphyrinic
PS
(Por)
noncovalently
loaded
naphthalocyanine
PTA
(VONc)
are
independently
responsible
PDT
PTT
functionalities
nanoagent.
Upon
visible
(red
LED)
NIR
(808
nm
laser)
irradiation,
(3)
displayed
high
1O2
generation
conversion
ability
(55.9%),
consequently
providing
combined
effect
on
inhibiting
MCF-7
tumor
cell
proliferation
metastasis,
was
well
evidenced
in
vitro
vivo
experiments.
We
believe
that
results
obtained
herein
can
significantly
promote
development
NCOF-based
biomedical
Advanced Functional Materials,
Год журнала:
2021,
Номер
31(25)
Опубликована: Март 31, 2021
Abstract
Photothermal
therapy
(PTT),
which
utilizes
near‐infrared
light‐absorbing
agents
to
ablate
tumor,
has
emerged
as
a
highly
promising
anticancer
strategy
and
received
intensive
clinical
trials
in
recent
years.
Mild‐temperature
PTT,
circumvents
the
limitations
of
conventional
PTT
(e.g.,
thermoresistance
adverse
effects),
is
emerging
shows
great
potential
forthcoming
applications.
However,
mild‐temperature
without
adjuvant
not
able
completely
eradicate
tumors
because
its
therapeutic
efficacy
dramatically
impaired
by
inferior
heat
intensity.
As
result,
strategies
capable
enhancing
are
urgently
necessitated,
mainly
rely
on
on‐demand
fabrication
functionalized
nanoagents.
In
this
review,
nanoagent‐promoted
highlighted.
Furthermore,
challenges
opportunities
field
rationally
proposed,
hopefully
people
can
be
encouraged
therapy.
Advanced Functional Materials,
Год журнала:
2020,
Номер
30(16)
Опубликована: Фев. 26, 2020
Abstract
Compared
with
conventional
tumor
photothermal
therapy
(PTT),
mild‐temperature
PTT
brings
less
damage
to
normal
tissues,
but
also
thermoresistance,
introduced
by
the
overexpressed
heat
shock
protein
(HSP).
A
high
dose
of
HSP
inhibitor
during
might
lead
toxic
side
effects.
Glucose
oxidase
(GOx)
consumes
glucose,
leading
adenosine
triphosphate
supply
restriction
and
consequent
inhibition.
Therefore,
a
combinational
use
an
GOx
not
only
enhances
minimizes
toxicity
inhibitor.
However,
inhibitor‐encapsulating
nanostructure,
designed
for
enhancing
its
efficiency,
has
been
reported.
Thermosensitive
GOx/indocyanine
green/gambogic
acid
(GA)
liposomes
(GOIGLs)
are
reported
enhance
efficiency
tumors
via
synergistic
inhibition
released
GA
GOx,
together
another
enzyme‐enhanced
phototherapy
effect.
In
vitro
in
vivo
results
indicate
that
this
strategy
starvation
significantly
efficiency.
This
could
inspire
people
design
more
delicate
platforms
combining
other
therapeutic
methods
efficient
cancer
treatment.
Materials Today Bio,
Год журнала:
2019,
Номер
5, С. 100035 - 100035
Опубликована: Ноя. 7, 2019
Cancer,
as
one
of
the
most
life-threatening
diseases,
shows
a
high
fatality
rate
around
world.
When
improving
therapeutic
efficacy
conventional
cancer
treatments,
researchers
also
conduct
extensive
studies
into
alternative
approaches,
which
are
safe,
valid,
and
economical.
Phototherapies,
including
photodynamic
therapy
(PDT)
photothermal
(PTT),
tumor-ablative
function-reserving
oncologic
interventions,
showing
strong
potential
in
clinical
treatment.
During
phototherapies,
non-toxic
phototherapeutic
agents
can
be
activated
upon
light
irradiation
to
induce
cell
death
without
causing
much
damage
normal
tissues.
Besides,
with
rapid
development
nanotechnology
past
decades,
phototheranostic
nanomedicine
has
attracted
tremendous
interests
aiming
continuously
refine
their
performance.
Herein,
we
reviewed
recent
progress
for
improved
therapy.
After
brief
introduction
principles
related
PDT
PTT,
existing
works
on
developing
by
mainly
focusing
categories
applications,
particularly
phototherapy-synergized
immunotherapy,
comprehensively
reviewed.
More
importantly,
conclusion
future
challenges
from
our
point
view
delivered
last
part
this
article.
Nanomedicine,
Год журнала:
2022,
Номер
17(5), С. 303 - 324
Опубликована: Янв. 21, 2022
Recent
studies
found
that
unbalanced
copper
homeostasis
affect
tumor
growth,
causing
irreversible
damage.
Copper
can
induce
multiple
forms
of
cell
death,
including
apoptosis
and
autophagy,
through
various
mechanisms,
reactive
oxygen
species
accumulation,
proteasome
inhibition,
antiangiogenesis.
Hence,
in
vivo
has
attracted
tremendous
attention
is
the
research
spotlight
field
treatment.
This
review
first
highlights
three
typical
copper's
antitumor
mechanisms.
Then,
development
diverse
biomaterials
nanotechnology
allowing
to
be
fabricated
into
structures
realize
its
theragnostic
action
discussed.
Novel
complexes
their
clinical
applications
are
subsequently
described.
Although
photothermal
therapy
(PTT)
with
the
assistance
of
nanotechnology
has
been
considered
as
an
indispensable
strategy
in
biomedical
field,
it
still
encounters
some
severe
problems
that
need
to
be
solved.
Excessive
heat
can
induce
treated
cells
develop
thermal
resistance,
and
thus,
efficacy
PTT
may
dramatically
decreased.
In
meantime,
uncontrollable
diffusion
pose
a
threat
surrounding
healthy
tissues.
Recently,
low-temperature
(also
known
mild
or
mild-temperature
PTT)
demonstrated
its
remarkable
capacity
conquering
these
obstacles
shown
excellent
performance
bacterial
elimination,
wound
healing,
cancer
treatments.
Herein,
we
summarize
recently
proposed
strategies
for
achieving
based
on
nanomaterials
introduce
synthesis,
characteristics,
applications
nanoplatforms.
Additionally,
combination
other
therapeutic
modalities
defeating
cancers
synergistic
effect
combined
treatments
are
discussed.
Finally,
current
limitations
future
directions
inspiring
more
researchers
make
contributions
promoting
toward
successful
preclinical
clinical
disease