Nanomaterials-based photothermal therapy and its potentials in antibacterial treatment

Journal of Controlled Release, Год журнала: 2020, Номер 328, С. 251 - 262

Опубликована: Сен. 1, 2020

Язык: Английский

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Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

Advanced Science, Год журнала: 2022, Номер 9(22)

Опубликована: Июнь 2, 2022

Abstract Tumor immunotherapy is only effective in a fraction of patients due to low response rate and severe side effects, these challenges clinics can be addressed through induction immunogenic cell death (ICD). ICD elicited from many antitumor therapies release danger associated molecular patterns (DAMPs) tumor‐associated antigens facilitate maturation dendritic cells (DCs) infiltration cytotoxic T lymphocytes (CTLs). The process reverse the tumor immunosuppressive microenvironment improve sensitivity immunotherapy. Nanostructure‐based drug delivery systems (NDDSs) are explored induce by incorporating therapeutic molecules for chemotherapy, photosensitizers (PSs) photodynamic therapy (PDT), photothermal conversion agents (PTT), radiosensitizers radiotherapy (RT). These NDDSs loaded at right dose place time, resulting greater effectiveness lower toxicity. Immunotherapeutic also combined with achieve synergic effect multi‐modality approach. In this review, harnessed load multiple PDT, PTT, RT combination promote reduce effects cancer treatment.

Язык: Английский

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Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Advanced Materials, Год журнала: 2020, Номер 33(4)

Опубликована: Дек. 2, 2020

Abstract The past decades have witnessed hyperthermia therapy (HTT) as an emerging strategy against malignant tumors. Nanomaterial‐based photothermal (PTT) and magnetic (MHT), highly effective noninvasive treatment models, offer advantages over other strategies in the of different types However, both PTT MHT cannot completely cure cancer due to recurrence distal metastasis. In recent years, immunotherapy has attracted widespread attention owing its capability activate body's own natural defense identify, attack, eradicate cells. Significant efforts been devoted studying activated immune responses caused by hyperthermia‐ablated this article, synergistic mechanism HTT immunotherapy, including immunogenic cell death reversal immunosuppressive tumor microenvironment is discussed. reports combination or HTT‐based multimodal with immunoadjuvant exploitation, checkpoint blockade therapy, adoptive cellular are summarized. As highlighted, these could achieve synergistically enhanced therapeutic outcomes primary tumors metastatic lesions, prevent recurrence, prolong survival period. Finally, current challenges prospective developments HTT‐synergized also reviewed.

Язык: Английский

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Nanoscale Covalent Organic Framework for Combinatorial Antitumor Photodynamic and Photothermal Therapy

ACS Nano, Год журнала: 2019, Номер 13(11), С. 13304 - 13316

Опубликована: Ноя. 5, 2019

Despite the excellent photodynamic and photothermal properties of organic molecular photosensitizers (PSs) agents (PTAs), such as porphyrin naphthalocyanine, their poor water solubility severely impedes biological applications. Covalent frameworks (COFs), an emerging class crystalline porous materials, possess free active end groups (bonding defects) large inner pores, which make them ideal type nanocarriers for loading hydrophobic PSs PTAs by both bonding defect functionalization (BDF) guest encapsulation approaches to obtain multifunctional nanomedicines PDT/PTT combination therapy. In this work, we report a nanoscale COF (NCOF) prepared via facile synthetic approach under ambient conditions. Furthermore, dual-modal therapeutic nanoagent, VONc@COF-Por (3), is successfully fabricated stepwise BDF processes. The covalently grafted porphyrinic PS (Por) noncovalently loaded naphthalocyanine PTA (VONc) are independently responsible PDT PTT functionalities nanoagent. Upon visible (red LED) NIR (808 nm laser) irradiation, (3) displayed high 1O2 generation conversion ability (55.9%), consequently providing combined effect on inhibiting MCF-7 tumor cell proliferation metastasis, was well evidenced in vitro vivo experiments. We believe that results obtained herein can significantly promote development NCOF-based biomedical

Язык: Английский

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Nanoagent‐Promoted Mild‐Temperature Photothermal Therapy for Cancer Treatment

Advanced Functional Materials, Год журнала: 2021, Номер 31(25)

Опубликована: Март 31, 2021

Abstract Photothermal therapy (PTT), which utilizes near‐infrared light‐absorbing agents to ablate tumor, has emerged as a highly promising anticancer strategy and received intensive clinical trials in recent years. Mild‐temperature PTT, circumvents the limitations of conventional PTT (e.g., thermoresistance adverse effects), is emerging shows great potential forthcoming applications. However, mild‐temperature without adjuvant not able completely eradicate tumors because its therapeutic efficacy dramatically impaired by inferior heat intensity. As result, strategies capable enhancing are urgently necessitated, mainly rely on on‐demand fabrication functionalized nanoagents. In this review, nanoagent‐promoted highlighted. Furthermore, challenges opportunities field rationally proposed, hopefully people can be encouraged therapy.

Язык: Английский

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Enzyme‐Mediated Tumor Starvation and Phototherapy Enhance Mild‐Temperature Photothermal Therapy

Advanced Functional Materials, Год журнала: 2020, Номер 30(16)

Опубликована: Фев. 26, 2020

Abstract Compared with conventional tumor photothermal therapy (PTT), mild‐temperature PTT brings less damage to normal tissues, but also thermoresistance, introduced by the overexpressed heat shock protein (HSP). A high dose of HSP inhibitor during might lead toxic side effects. Glucose oxidase (GOx) consumes glucose, leading adenosine triphosphate supply restriction and consequent inhibition. Therefore, a combinational use an GOx not only enhances minimizes toxicity inhibitor. However, inhibitor‐encapsulating nanostructure, designed for enhancing its efficiency, has been reported. Thermosensitive GOx/indocyanine green/gambogic acid (GA) liposomes (GOIGLs) are reported enhance efficiency tumors via synergistic inhibition released GA GOx, together another enzyme‐enhanced phototherapy effect. In vitro in vivo results indicate that this strategy starvation significantly efficiency. This could inspire people design more delicate platforms combining other therapeutic methods efficient cancer treatment.

Язык: Английский

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Multifunctional phototheranostic nanomedicine for cancer imaging and treatment

Materials Today Bio, Год журнала: 2019, Номер 5, С. 100035 - 100035

Опубликована: Ноя. 7, 2019

Cancer, as one of the most life-threatening diseases, shows a high fatality rate around world. When improving therapeutic efficacy conventional cancer treatments, researchers also conduct extensive studies into alternative approaches, which are safe, valid, and economical. Phototherapies, including photodynamic therapy (PDT) photothermal (PTT), tumor-ablative function-reserving oncologic interventions, showing strong potential in clinical treatment. During phototherapies, non-toxic phototherapeutic agents can be activated upon light irradiation to induce cell death without causing much damage normal tissues. Besides, with rapid development nanotechnology past decades, phototheranostic nanomedicine has attracted tremendous interests aiming continuously refine their performance. Herein, we reviewed recent progress for improved therapy. After brief introduction principles related PDT PTT, existing works on developing by mainly focusing categories applications, particularly phototherapy-synergized immunotherapy, comprehensively reviewed. More importantly, conclusion future challenges from our point view delivered last part this article.

Язык: Английский

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Copper-Induced Tumor Cell Death Mechanisms and Antitumor Theragnostic Applications of Copper Complexes

Nanomedicine, Год журнала: 2022, Номер 17(5), С. 303 - 324

Опубликована: Янв. 21, 2022

Recent studies found that unbalanced copper homeostasis affect tumor growth, causing irreversible damage. Copper can induce multiple forms of cell death, including apoptosis and autophagy, through various mechanisms, reactive oxygen species accumulation, proteasome inhibition, antiangiogenesis. Hence, in vivo has attracted tremendous attention is the research spotlight field treatment. This review first highlights three typical copper's antitumor mechanisms. Then, development diverse biomaterials nanotechnology allowing to be fabricated into structures realize its theragnostic action discussed. Novel complexes their clinical applications are subsequently described.

Язык: Английский

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Low temperature photothermal therapy: Advances and perspectives

Coordination Chemistry Reviews, Год журнала: 2021, Номер 454, С. 214330 - 214330

Опубликована: Дек. 2, 2021

Язык: Английский

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Low-Temperature Photothermal Therapy: Strategies and Applications

Research, Год журнала: 2021, Номер 2021

Опубликована: Янв. 1, 2021

Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells develop thermal resistance, and thus, efficacy PTT may dramatically decreased. In meantime, uncontrollable diffusion pose a threat surrounding healthy tissues. Recently, low-temperature (also known mild or mild-temperature PTT) demonstrated its remarkable capacity conquering these obstacles shown excellent performance bacterial elimination, wound healing, cancer treatments. Herein, we summarize recently proposed strategies for achieving based on nanomaterials introduce synthesis, characteristics, applications nanoplatforms. Additionally, combination other therapeutic modalities defeating cancers synergistic effect combined treatments are discussed. Finally, current limitations future directions inspiring more researchers make contributions promoting toward successful preclinical clinical disease

Язык: Английский

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