Molecules,
Год журнала:
2021,
Номер
26(11), С. 3311 - 3311
Опубликована: Май 31, 2021
In
the
natural
environment,
interactions
between
species
are
a
common
phenomena.
The
mechanisms
of
interaction
different
mainly
studied
using
genomic,
transcriptomic,
proteomic,
and
metabolomic
techniques.
Metabolomics
is
crucial
part
system
biology
based
on
precision
instrument
analysis.
last
decade,
emerging
field
metabolomics
has
received
extensive
attention.
not
only
provides
qualitative
quantitative
method
for
studying
species,
but
also
helps
clarify
defense
host
pathogen,
to
explore
new
metabolites
with
various
biological
activities.
This
review
focuses
methods
progress
interspecies
metabolomics.
Additionally,
prospects
challenges
discussed.
Journal of Separation Science,
Год журнала:
2025,
Номер
48(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Metabolomics,
a
powerful
discipline
within
systems
biology,
aims
at
comprehensive
profiling
of
small
molecules
in
biological
samples.
The
challenges
sample
complexity
are
addressed
through
innovative
preparation
methods,
including
solid‐phase
extraction
and
microextraction
techniques,
enhancing
the
detection
quantification
low‐abundance
metabolites.
Advances
chromatographic
separation,
particularly
liquid
chromatography
(LC)
gas
(GC),
coupled
with
high‐resolution
(HR)
mass
spectrometry
(MS),
have
significantly
improved
sensitivity,
selectivity,
throughput
metabolomic
studies.
Cutting‐edge
such
as
ion‐mobility
(IM‐MS)
tandem
MS
(MS/MS),
further
expand
capacity
for
metabolite
profiling.
These
advanced
analytical
platforms
each
offer
unique
advantages
metabolomics,
continued
technological
improvements
driving
deeper
insights
into
metabolic
pathways
biomarker
discovery.
By
providing
detailed
overview
current
trends
this
review
to
valuable
future
metabolomics
human
health
research
its
translational
potential
clinical
settings.
Toward
end,
also
highlights
biomedical
applications
emphasizing
role
discovery,
disease
diagnostics,
personalized
medicine,
drug
development.
Engineering,
Год журнала:
2018,
Номер
5(1), С. 60 - 68
Опубликована: Ноя. 30, 2018
Evaluation
of
the
efficacy
traditional
Chinese
medicines
(TCMs)
is
an
important
prerequisite
for
discovering
effective
substances,
lead
compounds,
and
quality
markers
(Q
markers).
At
present,
there
urgent
need
to
develop
a
biological
language
that
can
act
as
abridge
scientific
elaboration
TCMs,
further
highlight
significant
value
TCM.
medicinal
syndromes
formulae
are
two
essential
parts
TCM
directly
relate
its
efficacy.
Syndromes
have
been
taken
research
objects.
The
serum
pharmacochemistry
approach
with
metabolomics
were
integrated
establish
innovative
chinmedomics
strategy,
which
able
explore
syndrome
biomarkers
evaluate
in
order
discover
substances
from
TCMs.
A
great
deal
concrete
work
has
already
performed
bridge
gap
between
Western
medicine,
provide
powerful
enhance
theory
clinical
practice.
This
article
summarizes
application
identifying
candidate
revealing
related
formula.
We
also
discovery
compounds
Q
Metabolites,
Год журнала:
2020,
Номер
10(2), С. 47 - 47
Опубликована: Янв. 26, 2020
Metabolomic
profiling
of
biofluids,
e.g.,
urine,
plasma,
has
generated
vast
and
ever-increasing
amounts
knowledge
over
the
last
few
decades.
Paradoxically,
metabolomic
analysis
saliva,
most
readily-available
human
biofluid,
lagged.
This
review
explores
history
saliva-based
metabolomics
summarizes
current
salivary
metabolomics.
Current
applications
have
largely
focused
on
diagnostic
biomarker
discovery
value
literature
base
is
explored.
There
also
a
small,
albeit
promising,
concerning
use
in
monitoring
athletic
performance.
Functional
roles
metabolites
remain
unexplored.
Areas
emerging
include
role
oral
host–microbiome
interactions
shaping
metabolite
profile
potential
physiology,
taste
perception.
Discussion
future
research
directions
describes
need
to
begin
acquiring
greater
function
metabolites,
direction
field
gut
metabolome.
The
saliva
as
an
easily
obtainable,
information-rich
fluid
that
could
complement
other
gastrointestinal
fluids
exploration
metabolome
emphasized.
Plants,
Год журнала:
2021,
Номер
10(11), С. 2409 - 2409
Опубликована: Ноя. 8, 2021
Metabolomics
is
now
considered
a
wide-ranging,
sensitive
and
practical
approach
to
acquire
useful
information
on
the
composition
of
metabolite
pool
present
in
any
organism,
including
plants.
Investigating
metabolomic
regulation
plants
essential
understand
their
adaptation,
acclimation
defense
responses
environmental
stresses
through
production
numerous
metabolites.
Moreover,
metabolomics
can
be
easily
applied
for
phenotyping
plants;
thus,
it
has
great
potential
used
genome
editing
programs
develop
superior
next-generation
crops.
This
review
describes
recent
analytical
tools
techniques
available
study
metabolome,
along
with
significance
sample
preparation
using
targeted
non-targeted
methods.
Advanced
tools,
like
gas
chromatography-mass
spectrometry
(GC-MS),
liquid
chromatography
mass-spectroscopy
(LC-MS),
capillary
electrophoresis-mass
(CE-MS),
fourier
transform
ion
cyclotron
resonance-mass
(FTICR-MS)
matrix-assisted
laser
desorption/ionization
(MALDI),
mobility
(IMS)
nuclear
magnetic
resonance
(NMR)
have
speed
up
precise
metabolic
profiling
Further,
we
provide
complete
overview
bioinformatics
plant
metabolome
database
that
utilized
advance
our
knowledge
biology.
RSC Advances,
Год журнала:
2018,
Номер
8(74), С. 42380 - 42389
Опубликована: Янв. 1, 2018
The
human
gastrointestinal
tract
colonizes
a
large
number
of
microbial
microflora
to
participate
in
various
metabolic
processes
the
body,
and
plays
major
role
host
immune
response.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2021,
Номер
9
Опубликована: Фев. 23, 2021
Biomanufacturing
is
a
key
component
of
biotechnology
that
uses
biological
systems
to
produce
bioproducts
commercial
relevance,
which
are
great
interest
the
energy,
material,
pharmaceutical,
food,
and
agriculture
industries.
Biotechnology-based
approaches,
such
as
synthetic
biology
metabolic
engineering
heavily
reliant
on
“omics”
driven
characterize
understand
networks.
Knowledge
gained
from
experiments
aid
development
tools
advancement
studies
toward
establishing
robust
industrial
biomanufacturing
platforms.
In
this
review,
we
discuss
recent
advances
in
technologies,
compare
pros
cons
different
necessary
requirements
for
carrying
out
multi-omics
experiments.
We
highlight
influence
technologies
production
biofuels
by
engineering.
Finally,
application
agricultural
food
biotechnology,
review
impact
current
COVID-19
research.
