Deep Learning for Size‐Agnostic Inverse Design of Random‐Network 3D Printed Mechanical Metamaterials DOI Creative Commons
H. Pahlavani,

Kostas Tsifoutis‐Kazolis,

Mauricio Cruz Saldívar

и другие.

Advanced Materials, Год журнала: 2023, Номер 36(6)

Опубликована: Окт. 30, 2023

Abstract Practical applications of mechanical metamaterials often involve solving inverse problems aimed at finding microarchitectures that give rise to certain properties. The limited resolution additive manufacturing techniques requires such for specific specimen sizes. Moreover, the candidate should be resistant fatigue and fracture. Such a multi‐objective design problem is formidably difficult solve but its solution key real‐world metamaterials. Here, modular approach titled “Deep‐DRAM” combines four decoupled models proposed, including two deep learning (DL) models, generative model based on conditional variational autoencoders, direct finite element (FE) simulations. Deep‐DRAM integrates these into framework capable many solutions posed random‐network unit cells. Using an extensive set simulations as well experiments performed 3D printed specimens, it demonstrate that: 1) predictions DL are in agreement with FE experimental observations, 2) enlarged envelope achievable elastic properties (e.g., rare combinations double auxeticity high stiffness) realized using proposed approach, 3) can provide considered problem.

Язык: Английский

Kriging-assisted design of functionally graded cellular structures with smoothly-varying lattice unit cells DOI

Xiliang Liu,

Liang Gao, Mi Xiao

и другие.

Computer Methods in Applied Mechanics and Engineering, Год журнала: 2022, Номер 390, С. 114466 - 114466

Опубликована: Янв. 6, 2022

Язык: Английский

Процитировано

49
Micro-engineered architected metamaterials for cell and tissue engineering DOI Creative Commons
Chenyan Wang, Zacharias Vangelatos, Costas P. Grigoropoulos

и другие.

Materials Today Advances, Год журнала: 2022, Номер 13, С. 100206 - 100206

Опубликована: Янв. 13, 2022

Architected metamaterials are built upon the assembly of repeating cellular structures, exhibiting unprecedented mechanical properties attributed to tunability geometries. They have demonstrated a wide range applications in optical and electromagnetic fields, recently they employed as advanced tissue engineering scaffolds. The microgeometry-driven strategy enlarges design domain scaffold features enables more accurate manipulation cell-material interactions. In this review, we introduce most popular metamaterial designs biomedical summarize their representative fabricate vitro models vivo implants. These studies validate unique advantages supporting mechanobiological improving functionality replacements. Nevertheless, evolution meta-biomaterials requires detailed investigations relationship between structural cell phenotypes well theoretical models.

Язык: Английский

Процитировано

48
A novel hierarchical biofunctionalized 3D-printed porous Ti6Al4V scaffold with enhanced osteoporotic osseointegration through osteoimmunomodulation DOI Creative Commons
Wei Wang,

Yinze Xiong,

Renliang Zhao

и другие.

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Фев. 5, 2022

Abstract Background Femoral stem of titanium alloy has been widely used for hip arthroplasty with considerable efficacy; however, the application this implant in patients osteoporosis is limited due to excessive bone resorption. Macrophages participate regulation inflammatory response and have a topic increasing research interest field. However, few study explored link between macrophage polarization osteogenic–osteoclastic differentiation. The present aims develop novel hierarchical biofunctionalized 3D-printed porous Ti6Al4V scaffold enhanced osteoporotic osseointegration through immunotherapy. Method To improve osteointegration under osteoporosis, we developed (PT). Biomimetic extracellular matrix (ECM) was constructed inside interconnected pores PT micro-scale. And nano-scale, drug cargo icariin@Mg-MOF-74 (ICA@MOF) wrapped ECM-like structure that can control release icariin Mg 2+ . Results In scaffold, macroporous provides mechanical support, microporous facilitates cell adhesion enhances biocompatibility, nanostructure plays biological effect. We also demonstrate formation abundant new at peripheral internal sites after intramedullary implantation into distal femur rats. further find controlled-release from significantly M0 macrophages M2-type by inhibiting notch1 signaling pathway induce secretion anti-inflammatory cytokines; thus, it ameliorates metabolism, which contributes improving bone. Conclusion therapeutic potential implants containing controlled system are effective geriatric orthopaedic osseointegration. Graphical

Язык: Английский

Процитировано

47
Calcium Orthophosphate (CaPO4)-Based Bioceramics: Preparation, Properties, and Applications DOI Open Access
Sergey V. Dorozhkin

Coatings, Год журнала: 2022, Номер 12(10), С. 1380 - 1380

Опубликована: Сен. 21, 2022

Various types of materials have been traditionally used to restore damaged bones. In the late 1960s, a strong interest was raised in studying ceramics as potential bone grafts due their biomechanical properties. A short time later, such synthetic biomaterials were called bioceramics. Bioceramics can be prepared from diverse inorganic substances, but this review is limited calcium orthophosphate (CaPO4)-based formulations only, its chemical similarity mammalian bones and teeth. During past 50 years, there number important achievements field. Namely, after initial development bioceramics that just tolerated physiological environment, an emphasis shifted towards able form direct bonds with adjacent Afterwards, by structural compositional controls, it became possible choose whether CaPO4-based implants would remain biologically stable once incorporated into skeletal structure or they resorbed over time. At turn millennium, new concept regenerative developed, integrated part tissue engineering approach. Now, scaffolds are designed induce formation vascularization. These usually porous harbor various biomolecules and/or cells. Therefore, current biomedical applications include artificial grafts, augmentations, maxillofacial reconstruction, spinal fusion, periodontal disease repairs, well fillers tumor surgery. Prospective future comprise drug delivery purposes because CaPO4 appear promising carriers growth factors, bioactive peptides,

Язык: Английский

Процитировано

44
Deep Learning for Size‐Agnostic Inverse Design of Random‐Network 3D Printed Mechanical Metamaterials DOI Creative Commons
H. Pahlavani,

Kostas Tsifoutis‐Kazolis,

Mauricio Cruz Saldívar

и другие.

Advanced Materials, Год журнала: 2023, Номер 36(6)

Опубликована: Окт. 30, 2023

Abstract Practical applications of mechanical metamaterials often involve solving inverse problems aimed at finding microarchitectures that give rise to certain properties. The limited resolution additive manufacturing techniques requires such for specific specimen sizes. Moreover, the candidate should be resistant fatigue and fracture. Such a multi‐objective design problem is formidably difficult solve but its solution key real‐world metamaterials. Here, modular approach titled “Deep‐DRAM” combines four decoupled models proposed, including two deep learning (DL) models, generative model based on conditional variational autoencoders, direct finite element (FE) simulations. Deep‐DRAM integrates these into framework capable many solutions posed random‐network unit cells. Using an extensive set simulations as well experiments performed 3D printed specimens, it demonstrate that: 1) predictions DL are in agreement with FE experimental observations, 2) enlarged envelope achievable elastic properties (e.g., rare combinations double auxeticity high stiffness) realized using proposed approach, 3) can provide considered problem.

Язык: Английский

Процитировано

43