The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(21), С. 8298 - 8298

Опубликована: Ноя. 5, 2020

Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, anti-solvents in the synthesis crystallization active pharmaceutical ingredients (APIs), co-solvents emulsifiers drug formulations, (API-ILs) aiming liquid therapeutics, development and/or improvement drug-delivery-based systems. The present review focuses on use ILs field, covering their multiple applications from delivery. most relevant research conducted up date is presented discussed, together with a critical analysis significant IL-based strategies order improve performance therapeutics delivery

Язык: Английский

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Ru^II-Catalyzed/NH₂-Assisted Selective Alkenyl C–H [5 + 1] Annulation of Alkenylanilines with Sulfoxonium Ylides to Quinolines

Organic Letters, Год журнала: 2019, Номер 21(12), С. 4812 - 4815

Опубликована: Июнь 13, 2019

A novel ruthenium-catalyzed [5 + 1] annulation of 2-alkenylanilines with sulfoxonium ylides was developed for the rapid assembly highly functionalized quinolines. This new catalytic process employs challenging but synthetically ideal free amino functionality to achieve alkenyl C–H activation as one-carbon coupling partners. Various 2-acylquinolines could be obtained good yields and excellent functional group tolerance. Moreover, potential synthetic application this methodology exemplified by several chemical transformations.

Язык: Английский

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Recent advances in Rh(iii)/Ir(iii)-catalyzed C–H functionalization/annulation via carbene migratory insertion

Organic & Biomolecular Chemistry, Год журнала: 2021, Номер 19(7), С. 1438 - 1458

Опубликована: Янв. 1, 2021

The review highlighted diverse annulations, including nitrogen, oxygen, sulfur heterocycles and carbocylizations via Rh(iii)/Ir(iii)-catalyzed C–H functionalization/annulation with various arene carbene precursors.

Язык: Английский

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Rhodium-Catalyzed Reaction of Sulfoxonium Ylides and Anthranils toward Indoloindolones via a (4 + 1) Annulation

Organic Letters, Год журнала: 2019, Номер 21(17), С. 6653 - 6657

Опубликована: Авг. 19, 2019

A rhodium-catalyzed annulation between aroyl sulfoxonium ylides and anthranils has been developed to synthesize 10H-indolo[1,2-a]indol-10-one derivatives. This reaction started with an unpredented (4 + 1) toward N-(2-formylphenyl) indolones, proceeding the sequential ortho-amination of C–H bond in by insertion N–H carbene. Finally, Aldol condensation constructed second indole ring. procedure features formation two C–N bonds one C═C pot.

Язык: Английский

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Application of sulfoxonium ylide in transition-metal-catalyzed C-H bond activation and functionalization reactions

Tetrahedron, Год журнала: 2021, Номер 101, С. 132478 - 132478

Опубликована: Окт. 8, 2021

Язык: Английский

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Recent Advances in Metal‐Catalyzed C−H Bond Functionalization Reactions of Sulfoxonium Ylides

Asian Journal of Organic Chemistry, Год журнала: 2022, Номер 11(4)

Опубликована: Март 23, 2022

Abstract In recent years, the transition‐metal‐catalyzed functionalization reactions of sulfoxonium ylides have been explored extensively because their usefulness as carbene‐transfer agents, since they can produce metal carbenes through catalysis. Moreover, are safer and advantages simple handling good stability over other counterparts like diazo‐compounds. This review article attempts to highlight advances in metal‐catalyzed C−H ylides.

Язык: Английский

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Iridium-Catalyzed B–H Bond Insertion Reactions Using Sulfoxonium Ylides as Carbene Precursors toward α-Boryl Carbonyls

Organic Letters, Год журнала: 2019, Номер 21(22), С. 9005 - 9008

Опубликована: Ноя. 5, 2019

An iridium-catalyzed B–H bond insertion reaction between borane adducts and sulfoxonium ylides to afford α-boryl carbonyls has been developed. The starting materials are safe readily available. In addition, analogues of ylides, such as sulfonium salts could also be amenable the reaction.

Язык: Английский

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Water-mediated C–H activation of arenes with secure carbene precursors: the reaction and its application

Chemical Communications, Год журнала: 2019, Номер 55(76), С. 11418 - 11421

Опубликована: Янв. 1, 2019

A water-mediated C–H activation using sulfoxonium ylides is reported, providing a general, green and step-economic approach to construct C–C bond varieties of useful N-heterocycle scaffolds.

Язык: Английский

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Copper-Catalyzed Annulation or Homocoupling of Sulfoxonium Ylides: Synthesis of 2,3-Diaroylquinolines or α,α,β-Tricarbonyl Sulfoxonium Ylides

Organic Letters, Год журнала: 2020, Номер 22(4), С. 1504 - 1509

Опубликована: Фев. 11, 2020

An unprecedented copper-catalyzed reaction of sulfoxonium ylides and anthranils is reported that enables an easy access to 2,3-diaroylquinolines through a [4+1+1] annulation. Copper-catalyzed homocoupling provided α,α,β-tricarbonyl ylides, which provides strategy extend the carbon chain C–C bond formation. The utility products as well mechanistic details process are presented.

Язык: Английский

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Rhodium(III)-Catalyzed Annulative Coupling of Sulfoxonium Ylides and Allenoates: An Arene C–H Activation/Cyclopropanation Cascade

Organic Letters, Год журнала: 2019, Номер 21(22), С. 9217 - 9222

Опубликована: Ноя. 5, 2019

Rhodium(III)-catalyzed annulative coupling of sulfoxonium ylides with allenoates was achieved, forming highly functionalized cyclopropanes a quaternary carbon center by means the ylide functionality as traceless bifunctional directing group and C4 synthon via an arene C–H activation cyclopropanation cascade. The protocol features simultaneous formation three new C–C bonds in one pot excellent diastereoselectivity. resultant products could be further transformed to diverse synthetically useful compounds.

Язык: Английский

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