Chemical Society Reviews,
Год журнала:
2021,
Номер
50(14), С. 7941 - 8002
Опубликована: Янв. 1, 2021
Electrochemistry
has
recently
gained
increased
attention
as
a
versatile
strategy
for
achieving
challenging
transformations
at
the
forefront
of
synthetic
organic
chemistry.
Electrochemistry's
unique
ability
to
generate
highly
reactive
radical
and
ion
intermediates
in
controlled
fashion
under
mild
conditions
inspired
development
number
new
electrochemical
methodologies
preparation
valuable
chemical
motifs.
Particularly,
recent
developments
electrosynthesis
have
featured
an
use
redox-active
electrocatalysts
further
enhance
control
over
selective
formation
downstream
reactivity
these
intermediates.
Furthermore,
electrocatalytic
mediators
enable
proceed
manner
that
is
mechanistically
distinct
from
purely
methods,
allowing
subversion
kinetic
thermodynamic
obstacles
encountered
conventional
synthesis.
This
review
highlights
key
innovations
within
past
decade
area
electrocatalysis,
with
emphasis
on
mechanisms
catalyst
design
principles
underpinning
advancements.
A
host
oxidative
reductive
are
discussed
grouped
according
classification
transformation
nature
electrocatalyst.
Chemical Reviews,
Год журнала:
2021,
Номер
122(2), С. 2487 - 2649
Опубликована: Ноя. 9, 2021
Redox
processes
are
at
the
heart
of
synthetic
methods
that
rely
on
either
electrochemistry
or
photoredox
catalysis,
but
how
do
and
catalysis
compare?
Both
approaches
provide
access
to
high
energy
intermediates
(e.g.,
radicals)
enable
bond
formations
not
constrained
by
rules
ionic
2
electron
(e)
mechanisms.
Instead,
they
1e
mechanisms
capable
bypassing
electronic
steric
limitations
protecting
group
requirements,
thus
enabling
chemists
disconnect
molecules
in
new
different
ways.
However,
while
providing
similar
intermediates,
differ
several
physical
chemistry
principles.
Understanding
those
differences
can
be
key
designing
transformations
forging
disconnections.
This
review
aims
highlight
these
similarities
between
comparing
their
underlying
principles
describing
impact
electrochemical
photochemical
methods.
Chemical Reviews,
Год журнала:
2020,
Номер
121(1), С. 485 - 505
Опубликована: Окт. 5, 2020
Selective
C–C
bond
cleavage
under
mild
conditions
can
serve
as
a
valuable
tool
for
organic
syntheses
and
macromolecular
degradation.
However,
the
conventional
chemical
methods
have
largely
involved
use
of
noble
transition-metal
catalysts
well
stoichiometric
perhaps
environmentally
unfriendly
oxidants,
compromising
overall
sustainable
nature
transformation
chemistry.
In
this
regard,
electrochemical
has
been
identified
scalable
strategy
that
employs
electricity
to
replace
byproduct-generating
reagents.
To
date,
progress
made
in
area
mainly
relied
on
Kolbe
electrolysis
related
processes.
Encouragingly,
more
examples
bonds
via
other
maneuvers
recently
developed.
This
review
provides
an
overview
most
recent
significant
developments
electrochemically
oxidative
selective
cleavage,
with
emphasis
both
synthetic
outcomes
reaction
mechanisms,
it
showcases
innate
advantages
exciting
potentials
synthesis.
Green Synthesis and Catalysis,
Год журнала:
2021,
Номер
2(1), С. 19 - 26
Опубликована: Фев. 1, 2021
As
one
of
the
most
important
biogeochemical
cycles,
carbon
dioxide
(CO2)
cycle
between
atmosphere
and
biosphere
has
a
profound
impact
on
life
earth.
Therefore,
search
for
sustainable
solutions
to
normalize
currently
unbalanced
is
central
research
topic
many
scientific
disciplines.
The
green
electrocatalysis
offers
very
promising
answer
cycle.
In
this
review,
recent
advances
in
enabled
CO2
including
electrochemical
carboxylation
decarboxylative
functionalization
carboxylic
acids
are
highlighted.
Journal of the American Chemical Society,
Год журнала:
2021,
Номер
143(25), С. 9478 - 9488
Опубликована: Июнь 15, 2021
One
of
the
most
oft-employed
methods
for
C–C
bond
formation
involving
coupling
vinyl-halides
with
aldehydes
catalyzed
by
Ni
and
Cr
(Nozaki–Hiyama–Kishi,
NHK)
has
been
rendered
more
practical
using
an
electroreductive
manifold.
Although
early
studies
pointed
to
feasibility
such
a
process,
those
precedents
were
never
applied
others
due
cumbersome
setups
limited
scope.
Here
we
show
that
carefully
optimized
procedure
can
enable
sustainable
approach
NHK,
even
in
asymmetric
fashion
on
highly
complex
medicinally
relevant
systems.
The
e-NHK
non-canonical
substrate
classes,
as
redox-active
esters,
participate
low
loadings
when
conventional
chemical
techniques
fail.
A
combination
detailed
kinetics,
cyclic
voltammetry,
situ
UV–vis
spectroelectrochemistry
these
processes
illuminates
subtle
features
this
mechanistically
intricate
process.
Chemical Communications,
Год журнала:
2024,
Номер
60(42), С. 5502 - 5505
Опубликована: Янв. 1, 2024
An
organophotoelectrocatalytic
method
for
the
C(sp
2
)–H
alkylation
of
heteroarenes
with
unactivated
3
compounds
via
dehydrogenation
cross-coupling
was
developed.
Green Chemistry,
Год журнала:
2020,
Номер
23(1), С. 374 - 378
Опубликована: Окт. 23, 2020
Aryl
radicals
were
generated
for
the
first
time
from
aryl
acyl
peroxides
in
ethyl
acetate
under
ambient
conditions
and
visible-light
illumination
absence
of
any
additive,
metal
catalyst,
or
external
photosensitizer.
Angewandte Chemie International Edition,
Год журнала:
2020,
Номер
59(27), С. 10859 - 10863
Опубликована: Март 30, 2020
The
C-O
bond
cleavage
for
activation
of
alcohols
is
synthetically
useful
and
practically
challenging.
This
work
describes
carbazate
as
a
new
type
electrochemically
activated
alkylating
agent
derived
from
ubiquitous
direct
functionalization
heteroarenes
under
mild
electrolytic
conditions.
simple
undivided
cell
at
low
oxidative
potentials
with
carbon/platinum
electrode
set-ups
offers
excellent
substrate
tolerance,
affording
variety
primary,
secondary
tertiary
alkyl-decorated
heterocycles
in
good
chemical
yields.
Furthermore,
the
mechanism
this
electrochemical
deoxyalkylation
reaction
has
been
investigated.
