Aggregation‐enhanced theranostics: AIE sparkles in biomedical field

Aggregate, Год журнала: 2020, Номер 1(1), С. 80 - 106

Опубликована: Дек. 1, 2020

Abstract Theranostics referring to the ingenious integration of diagnostics and therapeutics has garnered tremendous attention in these years as it provides a promising opportunity for modern personalized precision medicine. By virtue good biocompatibility, outstanding fluorescence property, easy processability functionalization, promoted photosensitizing efficiency, well facile construction multi‐modality theranostics, fluorophores with aggregation‐induced emission (AIE) characteristics exhibit inexhaustible vigorous vitality field theranostics. Numerous significant breakthroughs state‐of‐the‐art progression have been witnessed past few years. This review highlights aggregation‐enhanced superiorities AIE luminogens (AIEgens) disease theranostics mainly involving diagnostic imaging (fluorescence room temperature phosphorescence), therapeutic intervention (photodynamic therapy), feasibility based on experimental measurements theoretical simulations. Additionally, latest advanced developments AIEgens aspect corresponding strategies design highly effective AIE‐active through triggering aggregation formation are comprehensively summarized. Moreover, brief conclusion discussion current challenges future perspectives this area is further presented.

Язык: Английский

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Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Chemical Reviews, Год журнала: 2021, Номер 122(1), С. 209 - 268

Опубликована: Окт. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Язык: Английский

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Applications of MOFs as Luminescent Sensors for Environmental Pollutants

Small, Год журнала: 2021, Номер 17(22)

Опубликована: Фев. 26, 2021

Abstract The environmental pollution has become a serious issue because the pollutants can cause permanent damage to DNA, nervous system, and circulating resulting in various incurable diseases, such as organ failure, malformation, angiocardiopathy, cancer. effective detection of is urgently needed keep them far away from daily life. Among reported pollutant sensors, luminescent metal–organic frameworks (LMOFs) with tunable structures have attracted remarkable attention detect their excellent selectivity, sensitivity, recyclability. Although lots framework (MOF)‐based sensors been summarized discussed previous reviews, pollutants, especially radioactive ions heavy metal ions, still not systematically presented. Here, sensing mechanisms construction principles MOFs are discussed, state‐of‐the‐art MOF‐based including pesticides, antibiotics, explosives, VOCs, toxic gas, small molecules, highlighted. This comprehensive review may further guide development promote practical applications for pollutants.

Язык: Английский

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Stimuli responsive dynamic transformations in supramolecular gels

Chemical Society Reviews, Год журнала: 2021, Номер 50(8), С. 5165 - 5200

Опубликована: Янв. 1, 2021

Stimuli responsive dynamic changes in the networks of self-assembled gels result an alteration physical and chemical properties gel with time.

Язык: Английский

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Nanoarchitectonics: what's coming next after nanotechnology?

Nanoscale Horizons, Год журнала: 2021, Номер 6(5), С. 364 - 378

Опубликована: Янв. 1, 2021

The nanoarchitectonics concept has the ability to bridge nanoscale science and visual size materials. final goal of approaches is creation living-creature-like functional material systems from simple objects.

Язык: Английский

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Multiple H‐Bonding Chain Extender‐Based Ultrastiff Thermoplastic Polyurethanes with Autonomous Self‐Healability, Solvent‐Free Adhesiveness, and AIE Fluorescence

Advanced Functional Materials, Год журнала: 2020, Номер 31(4)

Опубликована: Окт. 9, 2020

Abstract Developing an autonomous room temperature self‐healing supramolecular polyurethane (PU) with toughness and stiffness remains a great challenge. Herein, novel concept that utilizes T‐shaped chain extender double amide hydrogen bonds in side to extend PU prepolymers construct highly stiff tough integrated functions is reported. Mobile side‐chain H‐bonds afford large flexibility modulate the of PUs ranging from elastomer (105.87 MPa Young's modulus, 27 kJ m −2 tearing energy), solvent‐free hot‐melt adhesive, coating. The dynamic multiple self‐healability at (25 ° C). Due rapid reconstruction bonds, this adhesive demonstrates high adhesion strength, fast curing, reusability, long‐term adhesion, excellent low‐temperature resistance. Intriguingly, emits intrinsic blue fluorescence presumably owing aggregation‐induced emission tertiary amine domains induced by H‐bonds. explored as counterfeit ink coated on predesigned pattern, which visible‐light invisible UV‐light visible. This work represents universal facile approach fabricate supertough tailorable extension H‐bonding extenders.

Язык: Английский

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Structural and process controls of AIEgens for NIR-II theranostics

Chemical Science, Год журнала: 2020, Номер 12(10), С. 3427 - 3436

Опубликована: Июнь 12, 2020

Aggregation-induced emission (AIE) is a cutting-edge fluorescence technology, giving highly-efficient solid-state photoluminescence. Particularly, AIE luminogens (AIEgens) with in the range of second near-infrared window (NIR-II, 1000-1700 nm) have displayed salient advantages for biomedical imaging and therapy. However, molecular design strategy underlying mechanism regulating balance between (radiative pathway) photothermal effect (non-radiative these narrow bandgap materials remain obscure. In this review, we outline latest achievements guidelines photophysical process control developing highly efficient NIR-II emitters or agents aggregation-induced attributes. We provide insights to optimize efficiency by multi-hierarchical structures from single molecules (flexibilization) aggregates (rigidification). also discuss crucial role intramolecular motions balancing functions The superiority region demonstrated fluorescence/photoacoustic blood vessels brain as well ablation tumor. Finally, summary challenges perspectives AIEgens

Язык: Английский

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1,8-Naphthalimide-based fluorescent chemosensors: recent advances and perspectives

Journal of Materials Chemistry C, Год журнала: 2020, Номер 8(39), С. 13501 - 13529

Опубликована: Янв. 1, 2020

Application of the classic fluorescent dye 1,8-naphthalimide.

Язык: Английский

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Nanomaterials with Supramolecular Assembly Based on AIE Luminogens for Theranostic Applications

Advanced Materials, Год журнала: 2020, Номер 32(49)

Опубликована: Ноя. 4, 2020

Abstract One of the major pursuits biomedical science is to develop advanced strategies for theranostics, which expected be an effective approach achieving transition from conventional medicine precision medicine. Supramolecular assembly can serve as a powerful tool in development nanotheranostics with accurate imaging tumors and real‐time monitoring therapeutic process upon incorporation aggregation‐induced emission (AIE) ability. AIE luminogens (AIEgens) will not only enable fluorescence but also aid improving efficacy therapies. Furthermore, fluorescent signals performance these nanomaterials manipulated precisely owing reversible stimuli‐responsive characteristics supramolecular systems. Inspired by rapid advances this field, recent research conducted on effect based summarized. Here, three representative are presented follows: a) self‐assembly AIEgens, b) loading AIEgens within nanocarriers assembly, c) macrocycle‐guided via host–guest interactions. Meanwhile, diverse applications such diagnostics therapeutics have been discussed detail. Finally, challenges field listed review.

Язык: Английский

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Aggregation‐Induced Emission‐Active Gels: Fabrications, Functions, and Applications

Advanced Materials, Год журнала: 2021, Номер 33(33)

Опубликована: Июль 3, 2021

Abstract Chromophores that exhibit aggregation‐induced emission (i.e., luminogens [AIEgens]) emit intense fluorescence in their aggregated states, but show negligible as discrete molecular species solution due to the changes restriction and freedom of intramolecular motions. As solvent‐swollen quasi‐solids with both a compact phase free space, gels enable manipulation Thus, AIE‐active have attracted significant interest owing various distinctive properties promising application potential. Herein, comprehensive overview is provided. The fabrication strategies employed are detailed, applications AIEgens summarized. In addition, gel functions arising from AIE moieties revealed, along structure–property relationships. Furthermore, diverse areas illustrated. Finally, ongoing challenges potential means address them discussed, future perspectives on gels, overall aim inspiring research novel materials ideas.

Язык: Английский

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