A
three-component
reaction
of
trifluoromethyl
enones,
phosphine
oxides,
and
alcohols
in
water
solution
is
developed.
This
defluorinative
occurs
through
a
cascade
process
involving
defluorophosphorylation,
defluoroalkyloxylation,
defluoroheteroannulation,
enabling
the
modular
synthesis
furans
with
four
distinct
substituents:
C2-alkyloxy,
C3-trifluoromethyl,
C4-phosphoryl,
C5-(hetero)aryl
groups.
Moreover,
apart
from
alcohol
substrates,
scope
nucleophiles
could
be
further
extended
to
phenols,
azacycles,
or
sulfonamide.
Organic Letters,
Год журнала:
2023,
Номер
25(10), С. 1771 - 1775
Опубликована: Март 2, 2023
A
straightforward
cross-coupling
of
aryl
thioether
with
bromide
the
aid
nickel
salt,
magnesium,
and
lithium
chloride
in
tetrahydrofuran
at
ambient
temperature
was
accomplished.
The
one-pot
reactions
proceeded
efficiently
via
C-S
bond
cleavage
to
produce
desired
biaryls
modest
good
yields,
avoiding
use
pregenerated
or
commercial
organometallic
reagents.
ACS Catalysis,
Год журнала:
2023,
Номер
13(18), С. 12238 - 12268
Опубликована: Сен. 1, 2023
Organofluorine
compounds
have
attracted
extensive
attention
in
various
industrial
fields
due
to
their
unique
chemical
and
physical
properties.
Despite
increasing
demand
a
wide
range
of
scientific
fields,
the
synthesis
organofluorine
still
faces
several
problems,
such
as
difficulties
handling
fluorinating
reagents
control
chemoselectivity.
Compared
with
formation
C–F
bonds,
activation
functionalization
carbon–fluorine
bonds
is
very
important
but
challenging
topic
synthetic
chemistry.
Due
properties
nickel,
Ni-catalyzed
defluorinative
cross-couplings
been
greatly
developed
past
few
decades
powerful
strategies
for
construction
fluorinated
organic
compounds.
This
Review
summarizes
advances
cross-coupling
aryl
fluorides,
gem-difluorovinyl
trifluoromethyl
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(20), С. 5171 - 5179
Опубликована: Янв. 1, 2023
We
report
a
cross-electrophile
coupling
of
aryl
thiols
with
bromides
via
C–S
bond
activation
instead
S–H
cleavage.
The
reaction
proceeded
effectively
in
the
presence
nickel
catalyst,
magnesium,
and
lithium
chloride
to
afford
various
biaryls
moderate
good
yields.
Green Synthesis and Catalysis,
Год журнала:
2024,
Номер
5(4), С. 211 - 269
Опубликована: Май 6, 2024
The
development
of
catalytic
carbonylation
reactions
has
increased
considerably.
Although
many
reviews/chapters/books
on
have
been
published,
summaries
cheap
metal-catalyzed
aryl
halides
and
other
chemical
bonds
with
high
dissociation
energy
C-Y
(Y
=
O,
N,
H)
are
still
very
rare.
Focusing
green
sustainable
chemistry,
this
review
summarizes
discusses
the
achievements
carbonylative
transformations
(C(sp2)-X)
strong
based
non-expensive
metal
catalysts
(Co,
Mn,
Mo,
Ni,
Fe,
Cu),
photochemical
electrochemical
systems
developed
in
recent
decades.
Molecules,
Год журнала:
2024,
Номер
29(4), С. 831 - 831
Опубликована: Фев. 13, 2024
Hydroxylation
of
aryl
sulfonium
salts
could
be
realized
by
utilizing
acetohydroxamic
acid
and
oxime
as
hydroxylative
agents
in
the
presence
cesium
carbonate
a
base,
leading
to
variety
structurally
diverse
hydroxylated
arenes
47–95%
yields.
In
addition,
reaction
exhibited
broad
functionality
tolerance,
range
important
functional
groups
(e.g.,
cyano,
nitro,
sulfonyl,
formyl,
keto,
ester)
well
amenable
mild
conditions.
