Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation

Journal of the American Chemical Society, Год журнала: 2020, Номер 143(2), С. 538 - 559

Опубликована: Дек. 28, 2020

The past few decades have witnessed an evolution of nanomedicine from biologically inert entities to more smart systems, aimed at advancing in vivo functionality. However, we should recognize that most systems still rely on reasonable explanation-including some over-explanation-rather than definitive evidence, which is a watershed radically determining the speed and extent nanomedicine. Probing nano-bio interactions desirable functionality tissue, cellular, molecular levels frequently overlooked. Progress toward answering these questions will provide instructive insight guiding effective chemo-physical strategies. Thus, next generation, argue much effort be made evidence for proof-of-mechanism, lieu creating many new complicated similar proof-of-concept.

Язык: Английский

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A Forward Vision for Chemodynamic Therapy: Issues and Opportunities

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(7)

Опубликована: Янв. 17, 2023

Abstract Since the insight to fuse Fenton chemistry and nanomedicine into cancer therapy, great signs of progress have been made in field chemodynamic therapy (CDT). However, exact mechanism CDT is obscured by unique tumor chemical environment inevitable nanoparticle‐cell interactions, thus impeding further development. In this Scientific Perspective, significance clarified, complex deconstructed primitive biological research directions based on kinetics signaling pathways are discussed detail. Moreover, beneficial outlooks presented enlighten evolution next‐generation CDT. Hopefully, Perspective can inspire new ideas advances for provide a reference breaking down interdisciplinary barriers nanomedicine.

Язык: Английский

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Electromagnetic Nanomedicines for Combinational Cancer Immunotherapy

Angewandte Chemie International Edition, Год журнала: 2020, Номер 60(23), С. 12682 - 12705

Опубликована: Июль 16, 2020

Immunotherapy that harnesses the power of immune system to eliminate malignant cells has offered an effective approach for cancer treatment. However, limited patient response rates and potential immune-related adverse events exist as two major issues immunotherapy. In parallel, a variety electromagnetic nanomaterials generate heat and/or reactive oxygen species triggered by energy have been applied magnetic hyperthermia therapy, sonodynamic photothermal photodynamic radiotherapy, which ability induce immunogenic cell death. This review summarizes recent development nanomedicines in combinational The mechanisms reprogramming immunosuppressive tumor microenvironment sensitizing tumors immunotherapy are highlighted. Furthermore, challenges perspectives discussed.

Язык: Английский

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Recent developments of BODIPY-based colorimetric and fluorescent probes for the detection of reactive oxygen/nitrogen species and cancer diagnosis

Coordination Chemistry Reviews, Год журнала: 2021, Номер 439, С. 213936 - 213936

Опубликована: Апрель 16, 2021

Язык: Английский

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Reprogramming the Tumor Microenvironment through Second‐Near‐Infrared‐Window Photothermal Genome Editing of PD‐L1 Mediated by Supramolecular Gold Nanorods for Enhanced Cancer Immunotherapy

Advanced Materials, Год журнала: 2021, Номер 33(12)

Опубликована: Фев. 4, 2021

Abstract A photothermal genome‐editing strategy is described to improve immune checkpoint blockade (ICB) therapy by CRISPR/Cas9‐mediated disruption of PD‐L1 and mild‐hyperthermia‐induced activation immunogenic cell death (ICD). This relies on a supramolecular cationic gold nanorod that not only serves as carrier deliver CRISPR/Cas9 targeting , but also harvests the second near‐infrared‐window (NIR‐II) light converts into mild hyperthermia induce both ICD gene expression Cas9. The genomic significantly augments ICB improving conversion dendritic cells T cells, followed promoting infiltration cytotoxic lymphocytes tumors, thereby reprogramming immunosuppressive tumor microenvironment immunoactive one. Such therapeutic modality greatly inhibits activity primary metastatic tumors exhibits long‐term memory effects against rechallenged recurrent tumors. current for synergistic represents an appealing way cancer immunotherapy.

Язык: Английский

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Tumor-Associated-Macrophage-Membrane-Coated Nanoparticles for Improved Photodynamic Immunotherapy

Nano Letters, Год журнала: 2021, Номер 21(13), С. 5522 - 5531

Опубликована: Июнь 16, 2021

Cell-membrane-coated nanoparticles have emerged as a promising antitumor therapeutic strategy. However, the immunologic mechanism remains elusive, and there are still crucial issues to be addressed including tumor-homing capacity, immune incompatibility, immunogenicity. Here, we reported tumor-associated macrophage membrane (TAMM) derived from primary tumor with unique antigen-homing affinity capacity compatibility. TAMM could deplete CSF1 secreted by cells in microenvironment (TME), blocking interaction between TAM cancer cells. Especially, after coating upconversion nanoparticle conjugated photosensitizer (NPR@TAMM), NPR@TAMM-mediated photodynamic immunotherapy switched activation of macrophages an immunosuppressive M2-like phenotype more inflammatory M1-like state, induced immunogenic cell death, consequently enhanced immunity efficiency via antigen-presenting stimulate production tumor-specific effector T metastatic tumors. This TAM-membrane-based approach offers new strategy for personalized therapy.

Язык: Английский

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Nanoscale porous organic polymers for drug delivery and advanced cancer theranostics

Chemical Society Reviews, Год журнала: 2021, Номер 50(23), С. 12883 - 12896

Опубликована: Янв. 1, 2021

Finding a personalized nano theranostics solution, nanomedicine for cancer diagnosis and therapy, is among the top challenges of current medicinal science. Porous organic polymers (POPs) are permanent porous materials prepared by linking relatively rigid multidimensional building blocks. POP nanoparticles have remarkable advantage owing to their specific physicochemical characteristics such as high surface area, convincing pore size engineering, stimuli-responsive degradability, negligible toxicity, open covalent post-synthesis modification possibilities etc. POPs crystalline non-crystalline characteristics; popularly known frameworks (COFs), shown potential application across research areas in The early development on applications nanoscale has tremendous future clinical translation. This tutorial review highlights recently developed promising nPOPs drug loading, targeted delivery, endogenous exogenous release, imaging combination regardless poorly properties. will provide platform translation solving fundamental nanomedicines loading efficiency, size-optimization, biocompatibility, dispersibility cell uptake ability.

Язык: Английский

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Mild Magnetic Hyperthermia-Activated Innate Immunity for Liver Cancer Therapy

Journal of the American Chemical Society, Год журнала: 2021, Номер 143(21), С. 8116 - 8128

Опубликована: Апрель 30, 2021

Magnetic hyperthermia therapy (MHT) is noninvasive and features excellent tissue penetration for deep-seated tumors, but unfortunately, it suffers the low therapeutic efficacy due to limited magneto-thermal efficiency insufficient intratumor accumulation of conventional intravenous-injected magnetic nanoparticles, which are actually mostly sequestered by mononuclear phagocyte system, especially liver. Such a disadvantageous characteristic preferential liver uptake here exploited, first time as far we know, treat orthotopic cancer mild MHT using specially designed composite nanoparticles. A kind core–shell-structured Zn2+-doped Zn-CoFe2O4@Zn-MnFe2O4 superparamagnetic nanoparticles (ZCMF) has been synthesized exhibits highly controllable performance owing an exchange-coupled magnetism between core shell, Zn2+ doping. The at 43–44 °C based on ZCMF demonstrates almost complete inhibition cell proliferation tumor growth, associated with suppression heat shock protein 70 (HSP70) expression. More importantly, MHT-treated cells capable activating natural killer (NK) dramatically upregulating expression UL16-binding proteins (ULBPs), ligands group 2 member D (NKG2D). As result, growth both xenograft tumors were completely suppressed under via induced NK-cell-related antitumor immunity in vivo. This work not only evidences great potential also reveals underlying activation mechanism treatment MHT.

Язык: Английский

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Proteolysis-targeting chimera (PROTAC) delivery system: advancing protein degraders towards clinical translation

Chemical Society Reviews, Год журнала: 2022, Номер 51(13), С. 5330 - 5350

Опубликована: Янв. 1, 2022

This tutorial review discusses the convergence of drug delivery systems and PROTACs, surveys burgeoning PROTAC strategies, summarizes their design principles, clarifies challenges, outlooks future translational opportunities.

Язык: Английский

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Enhanced photodynamic therapy for overcoming tumor hypoxia: From microenvironment regulation to photosensitizer innovation

Coordination Chemistry Reviews, Год журнала: 2020, Номер 427, С. 213604 - 213604

Опубликована: Окт. 12, 2020

Язык: Английский

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