Unique roles in health promotion of dietary flavonoids through gut microbiota regulation: Current understanding and future perspectives

Food Chemistry, Год журнала: 2022, Номер 399, С. 133959 - 133959

Опубликована: Авг. 18, 2022

Язык: Английский

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Advances in traditional Chinese medicine for the treatment of chronic obstructive pulmonary disease

Journal of Ethnopharmacology, Год журнала: 2023, Номер 307, С. 116229 - 116229

Опубликована: Фев. 9, 2023

Язык: Английский

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Genome-wide identification of UDP-glycosyltransferases involved in flavonol glycosylation induced by UV-B irradiation in Eriobotrya japonica

Plant Physiology and Biochemistry, Год журнала: 2025, Номер 220, С. 109481 - 109481

Опубликована: Янв. 5, 2025

Язык: Английский

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Novel Sesquiterpene Glycoside from Loquat Leaf Alleviates Type 2 Diabetes Mellitus Combined with Nonalcoholic Fatty Liver Disease by Improving Insulin Resistance, Oxidative Stress, Inflammation, and Gut Microbiota Composition

Journal of Agricultural and Food Chemistry, Год журнала: 2021, Номер 69(47), С. 14176 - 14191

Опубликована: Ноя. 16, 2021

Nonalcoholic fatty liver disease (NAFLD) is strongly associated with type 2 diabetes mellitus (T2DM). Sesquiterpene glycosides from loquat leaf achieved beneficial effects on metabolic syndromes such as NAFLD and diabetes; however, their specific activity underlying mechanism T2DM-associated have not yet been fully understood. In the present study, we found that sesquiterpene glycoside 3 (SG3), a novel isolated leaf, was able to prevent insulin resistance (IR), oxidative stress, inflammation. db/db mice, SG3 administration (25 50 mg/kg/day) inhibited obesity, hyperglycemia, release of inflammatory cytokines. (5 10 μM) also significantly alleviated hepatic lipid accumulation, response induced by high glucose combined oleic acid in HepG2 cells. Western blotting analysis showed these were related repair abnormal signaling inhibit cytochrome P450 2E1 (CYP2E1) NOD-like receptor family pyrin domain-containing (NLRP3), both vivo vitro. addition, treatment could decrease ratio Firmicutes/Bacteroidetes increase relative abundance Lachnospiraceae, Muribaculaceae, Lactobacillaceae after high-throughput pyrosequencing 16S rRNA observe changes gut microbial composition mice. These findings proved protect against T2DM improving IR, inflammation through regulating inhibiting CYP2E1/NLRP3 pathways, remodeling mouse microbiome. It suggested be considered new functional additive for healthy diet.

Язык: Английский

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Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD

European Respiratory Review, Год журнала: 2022, Номер 31(164), С. 220028 - 220028

Опубликована: Июнь 14, 2022

COPD is predicted to become the third leading cause of morbidity and mortality worldwide by 2030. Cigarette smoking (active or passive) one its chief causes, with about 20% cigarette smokers developing from smoke (CS)-induced irreversible damage sustained inflammation airway epithelium. Inflammasome activation leads cleavage pro-interleukin (IL)-1β pro-IL-18, along release pro-inflammatory cytokines via gasdermin D N-terminal fragment membrane pores, which further triggers acute phase responses concurrent pyroptosis. There currently intense interest in role nucleotide-binding oligomerisation domain-like receptor family, pyrin domain containing protein-3 inflammasomes chronic inflammatory lung diseases such as their potential for therapeutic targeting. Phytochemicals including polyphenols flavonoids have phyto-medicinal benefits CS-COPD. Here, we review published articles last decade regarding known associations between inflammasome-mediated ameliorations pre-clinical manifestations CS-COPD polyphenol flavonoid treatment, a focus on underlying mechanistic insights. This article will potentially assist development drugs prevention therapy COPD, particularly smokers.

Язык: Английский

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Traditional uses, phytochemistry, pharmacology, and toxicity of Eriobotrya japonica leaves: A summary

Journal of Ethnopharmacology, Год журнала: 2022, Номер 298, С. 115566 - 115566

Опубликована: Июль 21, 2022

Язык: Английский

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Protective effect of total Saponins from American ginseng against cigarette smoke-induced COPD in mice based on integrated metabolomics and network pharmacology

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 149, С. 112823 - 112823

Опубликована: Март 23, 2022

Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disease. Aiming at assessing the effect of total saponins from American ginseng on COPD, both chemical composition and anti-COPD activity wild-simulated (TSW) field-grown (TSF) were investigated in this study. Firstly, HPLC-ELSD chromatographic method was established to simultaneously determine contents 22 TSW TSF. Secondly, CS-induced COPD mouse model evaluate The results indicated that TSF had protective against by alleviating oxidative stress inflammatory response. showed stronger than Thirdly, an integrated approach involving metabolomics network pharmacology used construct "biomarker-reaction-enzyme-target" correlation aiming further exploring observed effects. As results, 15 biomarkers, 9 targets 5 pathways identified play vital roles treatment COPD. Fourthly, based CS-stimulated A549 cell model, ginsenoside Rgl, Rc, oleanolic acid, notoginsenoside R1, Fe, silphioside B certified be material basis for Finally, molecular docking performed visualize binding modes. Our findings suggested could effectively ameliorate progression might

Язык: Английский

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Flavonoid intakes inversely associate with COPD in smokers

European Respiratory Journal, Год журнала: 2022, Номер 60(2), С. 2102604 - 2102604

Опубликована: Янв. 20, 2022

Introduction Higher flavonoid intakes are beneficially associated with pulmonary function parameters; however, their association chronic obstructive disease (COPD) is unknown. This study aimed to examine associations between of 1) total flavonoids, 2) subclasses and 3) major compounds incident COPD in participants from the Danish Diet, Cancer Health study. Methods prospective cohort included 55 413 men women without COPD, aged 50–65 years at recruitment. Habitual baseline were estimated a food frequency questionnaire using Phenol-Explorer. nationwide registers used identify cases COPD. Associations modelled restricted cubic splines within Cox proportional hazards models. Results During 23 follow-up, 5557 diagnosed Of these, 4013 current smokers, 1062 former smokers 482 never-smokers. After multivariable adjustments, highest had 20% lower risk than those lowest (quintile 5 versus quintile 1: HR 0.80, 95% CI 0.74–0.87); 6–22% was observed for each subclass. The inverse intake present both but only (HR 0.77, 0.70–0.84) 0.82, 0.69–0.97), not Furthermore, higher appeared lessen, negate, smoking intensity. Conclusion Dietary flavonoids may be important partially mitigating smoking-related However, cessation should remain priority.

Язык: Английский

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Plant-based therapeutics for chronic obstructive pulmonary diseases: Nanoformulation strategies to overcome delivery challenges

Food Bioscience, Год журнала: 2024, Номер 58, С. 103761 - 103761

Опубликована: Фев. 16, 2024

Chronic obstructive pulmonary disease (COPD) is a widespread global health problem marked by increasing airflow limitation and chronic airway inflammation. Conventional treatments for COPD offer limited efficacy have potentially undesirable effects, requiring the investigation of other therapeutic options. Because their anti-inflammatory, antioxidant, bronchodilatory plant-based chemicals emerged as viable candidates therapy. The successful delivery these compounds to respiratory system, on hand, remains an enormous challenge. This extensive review article explores promising potential therapies investigates leading-edge nanoformulation technologies targeted at addressing complex challenges that accompany natural compounds. We discuss multiple plant-derived (polyphenols, flavonoids, alkaloids) modes action in reducing COPD-related indications complications. Additionally, function nanotechnology improving bioavailability, stability, pharmaceuticals treatment explored. Nanoformulation techniques, such nanoparticles, liposomes, micelles, are described, with emphasis precisely encapsulate transport bioactive afflicted parts lung. Furthermore, constraints development nanoformulations also highlighted, including safety, scalability, regulatory issues. current aims provide thorough understanding future combining knowledge novel technologies. intersection nature-inspired medicines may hold key more effective, safer, patient-centred choices people suffering from this illness.

Язык: Английский

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Update on the Role of β2AR and TRPV1 in Respiratory Diseases

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10234 - 10234

Опубликована: Сен. 24, 2024

Respiratory diseases (RDs) constitute a common public health problem both in industrialized and developing countries. The comprehension of the pathophysiological mechanisms underlying these conditions development new therapeutic strategies are critical for improving quality life affected patients. β2-adrenergic receptor (β2AR) transient potential vanilloid 1 (TRPV1) involved physiological responses airways. β2AR is implicated bronchodilation, mucociliary clearance, anti-inflammatory effects, while TRPV1 mediation pain cough reflexes. In RDs, such as respiratory infections, asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, concentration expression receptors can be altered, leading to significant consequences. this review, we provided an update on literature about role conditions. We reported how diminished or defective during viral infections prolonged therapy with β2-agonists increase severity pathologies impact prognosis. Conversely, was pivotal neuroinflammation, its modulation could lead innovative treatment specific indicate future perspectives personalized treatments RDs through comprehensive analysis roles pathological pathologies.

Язык: Английский

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