Eurotium cristatum Fermented Loose Dark Tea Ameliorates Cigarette Smoke‐Induced Lung Injury by MAPK Pathway and Enhances Hepatic Metabolic Detoxification by PXR/AhR Pathway in Mice

Oxidative Medicine and Cellular Longevity, Год журнала: 2021, Номер 2021(1)

Опубликована: Янв. 1, 2021

Cigarette smoke‐ (CS‐) induced oxidative stress and inflammation in the lung are serious health problems. Primary reprocessed tea products contain multiple antioxidants that have been reported to protect against CS‐induced injury. However, beneficial effects of Eurotium cristatum fermented loose dark (ECT) particle metabolites (ECP) on injury its potential hepatic metabolic detoxification still unclear. Therefore, sixty mice were randomly divided into six equal groups. CS‐exposed prevented or treated with ECP ECT infusions for 12 8 weeks determine antioxidative stress, anti‐inflammatory ECP. Thirty‐six groups observe by replacing daily drinking water ECT. Results showed CS significantly decreased activities glutathione peroxidase (GSH‐Px) superoxide dismutase (SOD) upregulated expressions malondialdehyde (MDA), tumor necrosis factor alpha (TNF‐ α ), interleukin‐6 (IL‐6), IL‐8, IL‐1 β serum. These adverse modulated In addition, mRNA expression pregnane X receptor ( PXR ) cytochrome P450 CYP450 liver free group. Western blot analysis further revealed mice, phosphorylation mitogen‐activated protein kinase (MAPK) but aryl hydrocarbon AhR liver. Overall, our findings demonstrated protected via MAPK pathway enhanced pathways. intake can potentially inflammatory injuries.

Язык: Английский

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Effect of fermented milk on upper respiratory tract infection in adults who lived in the haze area of Northern China: a randomized clinical trial

Pharmaceutical Biology, Год журнала: 2021, Номер 59(1), С. 645 - 650

Опубликована: Янв. 1, 2021

Context Upper respiratory tract infection (URTI) is the most common illness in humans. Fermented milk containing probiotics can mitigate URTI symptoms.Objective This study tests effect of fermented (Qingrun), a yogurt supplemented with Bifidobacterium animalis subsp. lactis Bl-04, on adults URTIs who live haze-covered area randomized clinical trial.Materials and methods A total 136 subjects were enrolled at baseline to consume either control or Qingrun (250 g) once daily for 12 weeks. The duration severity evaluated by Wisconsin Respiratory Symptom Survey–24. Blood faecal samples collected post-intervention, determine changes immune biomarkers.Results significantly reduced incidence cold (OR, 0.38; 95% CI, 0.17–0.81; p = 0.013) influenza-like 0.32; 0.11–0.97; 0.045). Compared yogurt, (1.23 ± 2.73 vs. 4.78 5.09 d) score (3.58 7.12 11.37 11.73) URTI. In addition, post-intervention levels interferon-γ (139.49 59.49 113.45 65.12 pg/mL) secretory immunoglobulin (529.19 91.70 388.88 53.83 mg/dL) increased group, compared those group.Conclusions showed protective against adults, suggesting that use could be promising dietary supplement mitigating

Язык: Английский

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Role of TRPV1 in respiratory disease and association with traditional Chinese medicine: A literature review

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 155, С. 113676 - 113676

Опубликована: Сен. 9, 2022

Transient receptor potential vanilloid type 1 (TRPV1), involved in multiple pathophysiological processes including inflammation, is a thermally activated, non-selective cation channel. It has been identified that TRPV1 highly some common respiratory diseases allergic rhinitis, asthma, chronic obstructive pulmonary disease, and infection by participating neurogenic immunogenic sensitization, oxidative stress. In recent years, the hypothesis of transient (TRP) introduced studies on theory five flavors four properties Chinese medicinal. However, undetermined due to multi-component multi-target characteristics This study describes relations between types based literature years. meantime, therapeutic effect medicinal intervening was reviewed, an attempt provide certain evidence for future property-effect relationship, mechanism drug action, syndrome differentiation traditional medicine (TCM) help new development.

Язык: Английский

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Eriobotrya japonica (Thunb.) Lindl leaves: Reviewing their specialized metabolites and pharmacology

Biochemical Systematics and Ecology, Год журнала: 2023, Номер 110, С. 104707 - 104707

Опубликована: Авг. 7, 2023

Язык: Английский

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Grape Phytochemicals and Vitamin D in the Alleviation of Lung Disorders

Endocrine Metabolic & Immune Disorders - Drug Targets, Год журнала: 2022, Номер 22(13), С. 1276 - 1292

Опубликована: Апрель 7, 2022

Background: Typical lung diseases are pneumonia, asthma, sleep apnea syndrome (SA), interstitial pneumonia (IP), cancer, and chronic obstructive pulmonary disease (COPD). Coronavirus 2019 (COVID-19) is a type of viral pneumonia. Many researchers have reported that phytochemicals (chemical compounds produced by plants) vitamin D useful in stimulating our immunity. This review discusses the alleviation grape D. Discussion: Pneumonia an acute inflammation caused infection pathogens; worst case fatal cytokine storm lung. In allergens, tobacco smoke, or air pollution may cause seizures. Lung fibrosis manifest inflammation, progress into alveolar fibrosis, respiratory malfunction. SA lifestyle related to obesity metabolic syndrome. To alleviate these symptoms, changing eating habit one strategies. Improvement daily reduces risk cancer. Self-management, including nutritional management exercise, very important for COPD patients addition pharmacotherapy. Conclusion: The intake prevents diseases. Both prevent production proinflammatory cytokine, TNF-α, responsible Daily important. optimum level serum > 30 ng/mL. For prevention diseases, upregulating immunity maintaining good gut microbiota because change depending on what we eat.

Язык: Английский

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