Review of application of the I₂ and dimethyl sulfoxide combined reagent system to aryl methyl ketones for diverse transformations

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(9), С. 2665 - 2692

Опубликована: Янв. 1, 2024

The synthesis of small molecules and complex scaffolds is one the most important topics in organic synthesis.

Язык: Английский

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Pyrazolyl-pyrimidine porous-organic-polymer supported single-site nickel composites as efficient catalysts for the synthesis of substituted pyrimidines

Chemical Engineering Journal, Год журнала: 2023, Номер 474, С. 145642 - 145642

Опубликована: Авг. 25, 2023

Язык: Английский

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A review on the assembly of multi-substituted pyridines via Co-catalyzed [2 + 2 + 2] cycloaddition with nitriles

Organic & Biomolecular Chemistry, Год журнала: 2022, Номер 20(37), С. 7391 - 7404

Опубликована: Янв. 1, 2022

This review mainly focuses on the recent advances in Co-catalyzed [2 + 2 2] cycloaddition reaction of alkynes with nitriles to access multi-substituted pyridines. Meanwhile, brief mechanistic insights are also discussed explain observed regioselectivity.

Язык: Английский

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Water-promoted defluorinative synthesis of fluoroalkylated 1,5-diazapentadienes by using (NH₄)₂CO₃ as an NH₂ and NH source

Green Chemistry, Год журнала: 2023, Номер 25(23), С. 9672 - 9679

Опубликована: Янв. 1, 2023

A H 2 O-promoted and (NH 4 ) CO 3 -enabled defluoroiminization reaction of fluoroalkyl alkenes for the synthesis fluoroalkylated 1,5-diazapentadienes has been developed.

Язык: Английский

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Covalent Pyrimidine Frameworks via a Tandem Polycondensation Method for Photocatalytic Hydrogen Production and Proton Conduction

Small, Год журнала: 2023, Номер 19(14)

Опубликована: Янв. 12, 2023

The development of heteroaromatic conjugated porous polymers (H-CPPs) have received enormous research interests, because the important functional roles heteroatoms in photocatalysis and proton conduction. However, due to synthetic challenges deriving from stable structures, structural diversity methods them are still limited. Herein, a new type H-CPPs, covalent pyrimidine frameworks (CPFs), via an efficient tandem polycondensation reaction between aldehyde, acetyl, amidine monomers is reported. resulting CPFs bridged by units, rich nitrogen atoms can be structurally regulated on demand. shown active photocatalysts for hydrogen evolution methanol photo-thermo-catalysis process, achieving excellent rate 5282.8 µmol h-1 g-1 . further processed into mixed matrix membrane, displaying conductivity 1.30 × 10-2 S cm-1 at 413 K under anhydrous condition.

Язык: Английский

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Primary Amination of Ar₂P(O)–H with (NH₄)₂CO₃ as an Ammonia Source under Simple and Mild Conditions and Its Extension to the Construction of Various P–N or P–O Bonds

The Journal of Organic Chemistry, Год журнала: 2022, Номер 87(5), С. 3254 - 3264

Опубликована: Янв. 24, 2022

A facile and efficient method for the synthesis of primary phosphinamides from Ar2P(O)-H reagents with stable readily available ammonium carbonate as an ammonia source is disclosed herein first time. This ethyl bromoacetate-mediated amination proceeds smoothly under mild simple conditions, without any metal catalyst or oxidant. Moreover, this also appropriate reaction a variety amines, alcohols, phenols to construct P-N P-O bonds, features handy operation, good functional group tolerance, broad substrate scope.

Язык: Английский

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Transition‐Metal‐Free Synthesis of N‐Heterocyclic Compounds via Multi‐Component Reactions

Asian Journal of Organic Chemistry, Год журнала: 2023, Номер 12(9)

Опубликована: Июль 29, 2023

Abstract Multicomponent reactions (MCRs) have emerged as powerful tools in synthetic chemistry for the efficient synthesis of diverse molecular scaffolds, particularly nitrogen‐containing heterocycles. Despite their numerous advantages, use transition metal catalysts or additives MCRs can present limitations due to cost, toxicity, and environmental concerns. In recent years, there has been a growing interest metal‐free N ‐heterocyclic compounds. This review provides comprehensive concise overview advancements valuable ‐heterocycles over past five years. The is systematically organized, categorizing discussed based on size heterocyclic ring number nitrogen atoms. Only that result formation rings containing at least one atom are included, while derivatization using falls outside scope this review. By highlighting developments field, aims showcase potential significance sustainable strategies accessing elimination metals not only simplifies reaction conditions but also contributes greener more environmentally friendly approaches. serves resource researchers interested design application

Язык: Английский

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Metal- and Solvent-Free Synthesis of Substituted Pyrimidines via an NH₄I-Promoted Three-Component Tandem Reaction

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(20), С. 14697 - 14707

Опубликована: Сен. 29, 2023

A facile and practical approach for the preparation of substituted pyrimidines from ketones, NH4OAc, N,N-dimethylformamide dimethyl acetal has been described. This NH4I-promoted three-component tandem reaction affords a broad range in acceptable yields under metal- solvent-free conditions. The present methodology features advantages simple easily available starting materials, conditions, substrate scope with good functional group tolerance, gram-scale synthesis.

Язык: Английский

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Multicomponent synthesis via acceptorless alcohol dehydrogenation: an easy access to tri-substituted pyridines

RSC Advances, Год журнала: 2024, Номер 14(15), С. 10761 - 10767

Опубликована: Янв. 1, 2024

The multicomponent synthesis of 2,4,6-trisubstituted pyridine via acceptorless alcohol dehydrogenation using ammonium acetate as a nitrogen source catalyzed by hydroxyapatite-supported palladium nanoparticles heterogeneous catalyst.

Язык: Английский

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Construction of a Pyrimidine Framework through [3 + 2 + 1] Annulation of Amidines, Ketones, and N,N-Dimethylaminoethanol as One Carbon Donor

The Journal of Organic Chemistry, Год журнала: 2021, Номер 86(19), С. 13734 - 13743

Опубликована: Сен. 20, 2021

An efficient, facile, and eco-friendly synthesis of pyrimidine derivatives has been developed. It involves a [3 + 2 1] three-component annulation amidines, ketones, one carbon source. N,N-Dimethylaminoethanol is oxidized through C(sp3)-H activation to provide the donor. One C-C two C-N bonds are formed during oxidative process. The reaction shows good tolerance many important functional groups in air, making this methodology highly versatile alternative, significant improvement existing methods for structuring framework, especially 4-aliphatic pyrimidines.

Язык: Английский

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