The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(20), С. 14697 - 14707
Опубликована: Сен. 29, 2023
A
facile
and
practical
approach
for
the
preparation
of
substituted
pyrimidines
from
ketones,
NH4OAc,
N,N-dimethylformamide
dimethyl
acetal
has
been
described.
This
NH4I-promoted
three-component
tandem
reaction
affords
a
broad
range
in
acceptable
yields
under
metal-
solvent-free
conditions.
The
present
methodology
features
advantages
simple
easily
available
starting
materials,
conditions,
substrate
scope
with
good
functional
group
tolerance,
gram-scale
synthesis.
Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(9)
Опубликована: Июль 29, 2023
Abstract
Multicomponent
reactions
(MCRs)
have
emerged
as
powerful
tools
in
synthetic
chemistry
for
the
efficient
synthesis
of
diverse
molecular
scaffolds,
particularly
nitrogen‐containing
heterocycles.
Despite
their
numerous
advantages,
use
transition
metal
catalysts
or
additives
MCRs
can
present
limitations
due
to
cost,
toxicity,
and
environmental
concerns.
In
recent
years,
there
has
been
a
growing
interest
metal‐free
N
‐heterocyclic
compounds.
This
review
provides
comprehensive
concise
overview
advancements
valuable
‐heterocycles
over
past
five
years.
The
is
systematically
organized,
categorizing
discussed
based
on
size
heterocyclic
ring
number
nitrogen
atoms.
Only
that
result
formation
rings
containing
at
least
one
atom
are
included,
while
derivatization
using
falls
outside
scope
this
review.
By
highlighting
developments
field,
aims
showcase
potential
significance
sustainable
strategies
accessing
elimination
metals
not
only
simplifies
reaction
conditions
but
also
contributes
greener
more
environmentally
friendly
approaches.
serves
resource
researchers
interested
design
application
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(20), С. 14697 - 14707
Опубликована: Сен. 29, 2023
A
facile
and
practical
approach
for
the
preparation
of
substituted
pyrimidines
from
ketones,
NH4OAc,
N,N-dimethylformamide
dimethyl
acetal
has
been
described.
This
NH4I-promoted
three-component
tandem
reaction
affords
a
broad
range
in
acceptable
yields
under
metal-
solvent-free
conditions.
The
present
methodology
features
advantages
simple
easily
available
starting
materials,
conditions,
substrate
scope
with
good
functional
group
tolerance,
gram-scale
synthesis.
