Progress in heterocyclic chemistry, Год журнала: 2019, Номер unknown, С. 281 - 323
Опубликована: Окт. 13, 2019
Язык: Английский
ACS Central Science, Год журнала: 2021, Номер 7(4), С. 536 - 558
Опубликована: Март 16, 2021
Phosphorus-based organocatalysis encompasses several subfields that have undergone rapid growth in recent years. This Outlook gives an overview of its various aspects. In particular, we highlight key advances three topics: nucleophilic phosphine catalysis, organophosphorus catalysis to bypass oxide waste, and compound-mediated single electron transfer processes. We briefly summarize five additional chiral phosphoric acid Lewis base iminophosphorane super phosphonium salt phase frustrated pair catalysis. Although it is not catalytic nature, also discuss novel discoveries are emerging phosphorus(V) ligand coupling. conclude with some ideas about the future
Язык: Английский
Процитировано
243
Organic Letters, Год журнала: 2019, Номер 22(1), С. 164 - 167
Опубликована: Дек. 23, 2019
A straight synthetic approach to fused polycyclic tropane scaffold formation through an asymmetric dearomatization cycloaddition process of 2-nitrobenzofurans with cyclic azomethine ylides was successfully developed. In the presence a chiral copper complex, derived from Cu(OAc)2 and diphosphine ligand, series derivatives were obtained in high yields (75–91%) excellent enantioselectivities (90–98%). The utility this method showcased by facile transformation product.
Язык: Английский
Процитировано
55
Chemical Communications, Год журнала: 2019, Номер 55(62), С. 9144 - 9147
Опубликована: Янв. 1, 2019
The phosphine-catalyzed asymmetric dearomative [3+2] cycloaddition of 2-nitrobenzofurans with aldehyde-derived Morita-Baylis-Hillman (MBH) carbonates or allenoate was developed. reaction MBH resulted in a series cyclopentabenzofurans containing three contiguous stereocenters good to high yields, diastereoselectivities and enantioselectivities. use also gave the target product moderate enantioselectivity.
Язык: Английский
Процитировано
53
Organic Letters, Год журнала: 2019, Номер 21(14), С. 5452 - 5456
Опубликована: Июнь 28, 2019
Organocatalytic asymmetric dearomatization of 3-nitroindoles and 3-nitrobenzothiophenes by reaction with ethyl 4-mercapto-2-butenoate has been developed. A range chiral tetrahydrothiopheneindolines tetrahydrothiophenebenzothiophenes bearing three contiguous stereocenters are obtained in high yields good diastereoselectivities excellent enantioselectivities. This is the first example thiol-triggered catalytic 3-nitrobenzothiophenes.
Язык: Английский
Процитировано
48
Asian Journal of Organic Chemistry, Год журнала: 2021, Номер 10(5), С. 932 - 948
Опубликована: Март 10, 2021
Abstract This review article discusses about the recent developments in area of strategies for dearomatization benzofurans and benzothiophenes (2010–2020). The readers can understand current state art this intriguingly important organic synthesis generation diversely functionalized molecules, polycyclic systems from highly abundant benzothiophenes. We hope that would help synthetic community design development new as well further growth novel rapidly growing research.
Язык: Английский
Процитировано
36
Synthesis, Год журнала: 2020, Номер 52(10), С. 1451 - 1477
Опубликована: Март 16, 2020
This review gives an overview on recent developments in methods for the construction of compounds with 2,3-dihydrobenzofuran core period 2012 to 2019. Interest 2,3-dihydrobenzofurans is constantly increasing. The are divided into intermolecular and intramolecular approaches. Intermolecular approaches subdivided according parent intermediate key reaction, while by which bond formed reaction. transformation benzofurans dihydrobenzofurans other miscellaneous also discussed. Approaches useful synthesis natural products emphasized. 1 Introduction 2 2.1 o-Quinone Methides o-Quinones 2.2 p-Quinone p-Quinones 2.3 Nitrogen-Containing Phenols Quinones 2.4 o-Hydroxyphenylcarbonyl Derivatives 2.5 Miscellaneous 3 Intramolecular 3.1 O–C2 Bond Forming 3.2 C2–C3 3.3 C3–Aryl 3.4 O–Aryl 4 From BF DHB 5 Rearrangements Aromatizations
Язык: Английский
Процитировано
35
Chemistry - A European Journal, Год журнала: 2019, Номер 25(60), С. 13688 - 13693
Опубликована: Сен. 11, 2019
3-Nitroindoles are easily reacted with highly substituted γ-allenoates in the presence of a commercially available phosphine catalyst. For instance, allenoates derived from biomolecules such as amino and deoxycholic acids combined for first time 3-nitroindole. The corresponding dearomatized (3+2) tricyclic cycloadducts obtained α-regioisomers exclusively. DFT computations shed light on this multi-step reaction mechanism selectivities observed sequence.
Язык: Английский
Процитировано
31
Tetrahedron, Год журнала: 2022, Номер 126, С. 133053 - 133053
Опубликована: Окт. 5, 2022
Язык: Английский
Процитировано
18
European Journal of Organic Chemistry, Год журнала: 2022, Номер 2022(18)
Опубликована: Апрель 5, 2022
Abstract Dearomatization reactions employing simple aromatic compounds have showcased remarkable progress in the recent decade and emerged as one of most straightforward powerful tools for creation highly functionalized, three‐dimensional molecular frameworks commonly encountered medicinal chemistry life sciences. Among use, nitro(hetero)arenes, which feature a less pronounced character due to presence electron‐withdrawing nitro group, been extensively used different types dearomatization reactions. The dearomative annulation reaction serves versatile method construction complex polycyclic systems. This overview presents brief summary impressive advances nitro(hetero)arenes provides some inspirations future research.
Язык: Английский
Процитировано
17
Organic Letters, Год журнала: 2021, Номер 23(5), С. 1814 - 1819
Опубликована: Фев. 16, 2021
We have developed a metal-free, mild, and green synthetic route toward benzothieno[3,2-b]benzofurans by the annulation of 3-nitrobenzothiophene with phenols. The reaction was found to be general range substituted In addition, we could extend methodology for synthesis pentacenes demonstrate in gram-scale. Moreover, extended strategy benzothieno[2,3-b]benzofurans starting from 2-nitrobenzothiophenes.
Язык: Английский
Процитировано
22