PubMed,
Год журнала:
2023,
Номер
37(1), С. 63 - 67
Опубликована: Янв. 1, 2023
Objective:To
investigate
the
effect
and
influencing
factors
of
individualized
operation
for
congenital
preauricular
fistula
in
children.
Methods:The
clinical
data
98
cases
（109
ears）
treated
Department
Otolaryngology，Fuzhou
Children's
Hospital
Fujian
Medical
University
from
July
2016
to
December
2020
were
retrospectively
analyzed.
According
characteristics
infection
fistula，they
divided
into
common
type
variant
type，static
period
inflammation
infection.Individual
surgical
methods
such
as
classical
resection,
double
fusiform
incision
location
resection
used
respectively.The
efficacy，complication
different
Results:The
time
was
shorter,
difference
statistically
significant（t
=
－2.905
and－3.005
respectively,
all
P<0.05）.
stages
types
fistulas,
selection
had
achieved
good
results.
There
no
significant
complications
recurrence
among
（all
P>0.05）.
Conclusion:Once
occurs
fistula,
should
be
performed
soon
possible
after
control,
or
early
maximum
control
if
cannot
completely
subside.
Surgical
design
individualized,
complete
fistulas
lesions,
minimally
invasive
aesthetic.目的：探讨儿童先天性耳前瘘管个体化手术方式的疗效及影响因素。
方法：回顾性分析2016年7月—2020年12月福建医科大学附属福州儿童医院耳鼻咽喉科收治的98例（109耳）先天性耳前瘘管患儿的临床资料，根据瘘管特点及感染控制情况分为普通型与变异型、炎症静止期与感染局限期，分别采用经典瘘管切除法、双梭形切口法、瘘口定位切除法等个体化手术方式，分析不同手术方式的疗效、并发症及影响因素。
结果：除经典瘘管切除法的手术时间较双梭形切口法、瘘口定位切除法明显缩短，差异有统计学意义（t分别为-2.905、-3.005，均P<0.05）外，三种手术方式均取得较好的疗效，切口并发症、瘘管复发等的差异均无统计学意义（均P>0.05）。
结论：先天性耳前瘘管一旦出现感染，应在感染完全控制或最大化控制后早期手术。手术方式应个体化，彻底切除瘘管及病灶的同时兼顾微创及美观。.
The Journal of Organic Chemistry,
Год журнала:
2021,
Номер
86(2), С. 1827 - 1842
Опубликована: Янв. 2, 2021
The
three-component
reaction
of
α,β-unsaturated
N-arylaldimines,
dialkyl
but-2-ynedioates,
and
2-arylidene
Meldrum
acids
in
DCM
at
room
temperature
gave
mixtures
cis/trans-11-aryl-7-styryl-2,4-dioxa-8-azaspiro[5.5]undec-9-enes
satisfactory
yields.
similar
with
2-arylidene-N,N′-dimethylbarbituric
afforded
cis-11-phenyl-7-styryl-2,4,8-triazaspiro[5.5]undec-9-enes
as
major
products.
On
the
other
hand,
or
cis/trans-isomeric
spirocompounds
yields
high
diastereoselectivity.
This
domino
[2+2+2]
cycloaddition
proceeded
sequential
nucleophilic
addition
N-arylaldimine
to
an
electron-deficient
alkyne,
Michael
addition,
annulation
process.
stereochemistry
all
cis/trans
isomeric
was
clearly
elucidated
by
determination
33
single-crystal
structures.
diastereoselectivity
correlated
DFT
calculations.
Abstract
Herein,
a
Cs
2
CO
3
‐promoted
N
‐alkylation
of
3‐cyano‐2(1
H
)‐pyridones
containing
alkyl
groups
with
diverse
halides
to
synthesize
‐alkyl‐2‐pyridones
over
O
‐alkylpyridines
is
reported.
The
use
dihalides
resulted
in
complex
mixtures
‐
and
‐alkylated
products.
primary
factor
influencing
regioselectivity
these
reactions
the
electronic
effects
substituents
on
2(1
)‐pyridone
ring,
as
evidenced
by
preferential
formation
upon
introduction
aryl
groups.
Remarkably,
we
efficiently
employed
CuAAC
Ti(O
i
‐Pr)
4
‐catalyzed
amidation
functionalize
propargyl
ester
groups,
leading
synthesis
1,2,3‐triazoles
amides,
respectively.
Moreover,
10
b
d
displayed
remarkable
selectivity
toward
A‐498
renal
cancer
cell
line
growth
inhibition
percentages
(%GI)
54.75
67.64,
binding
modes
compounds
PIM‐1
kinase
enzyme
were
determined
through
molecular
docking
studies.
The Journal of Organic Chemistry,
Год журнала:
2020,
Номер
85(19), С. 12117 - 12127
Опубликована: Сен. 9, 2020
The
three-component
reaction
of
alkyl
2-(benzo[b][1,4]thiazin-3-ylidene)acetates,
isatins,
and
1,3-indanedione
(1,3-cyclopentanedione)
in
ethanol
the
presence
acetic
acid
conveniently
afforded
spiro[indeno[1,2-b]phenothiazine-6,3′-indolines]
or
spiro[cyclopenta[b]phenothiazine-4,3′-indolines]
good
yields
with
high
diastereoselectivity.
More
interestingly,
a
similar
4-hydroxychromen-2-one
resulted
unexpected
polycyclic
spiro[benzo[b]chromeno[3′,4′:5,6]pyrano[2,3-e][1,4]thiazine-7,3′-indolines]
satisfactory
yields.
A
plausible
mechanism
was
rationally
proposed
for
formation
different
kinds
spiro
compounds,
stereochemistries
various
compounds
were
clearly
elucidated.
Chinese Journal of Chemistry,
Год журнала:
2021,
Номер
39(10), С. 2781 - 2788
Опубликована: Июнь 27, 2021
Main
observation
and
conclusion
In
this
article,
we
report
a
base‐promoted
sequential
cyclization/aldol‐type
condensation/isomerization
cascade
reaction
of
N
‐propargyl‐β‐enaminones
with
aryl
aldehydes.
The
key
step
in
protocol
is
the
generation
1,4‐oxazepine
anions
from
under
basic
conditions,
which
are
captured
by
method
allows
formation
one
pyridone
core
C—C
double
bond
“one
pot”,
preparation
variety
densely
decorated
derivatives
moderate
to
good
yields
broad
functional
group
tolerance.
Asian Journal of Organic Chemistry,
Год журнала:
2021,
Номер
10(12), С. 3370 - 3373
Опубликована: Окт. 20, 2021
Abstract
In
this
report,
a
practical
synthetic
approach
to
access
N
‐aryl/
‐alkyl
4‐pyridones
via
two‐step
continuous
flow
process
has
been
developed.
comparison
batch
conditions,
[3+2+1]
cycloaddition
involving
three‐components
cascade
reaction
of
aniline,
dialkyl
ethoxymethyl
enemalonate
and
acetylenedicarboxylate
under
mild
which
can
provide
4‐pyridone
derivatives
with
wider
substrate
scope
good
excellent
yields.
Abstract
A
simple
and
rapid
methodology
for
the
synthesis
of
fully
substituted
pyrroles
was
accomplished
by
reaction
microwave‐assisted
from
amines,
4‐hydroxycoumarins,
ketones.
This
protocol
proceeds
via
ketones
Csp
3
−H
oxidation
Michael
addition/
cyclization/
aromatization
four‐component
cascade
affording
pyrrole
in
moderate
to
excellent
yields
only
min.
Simple
conditions,
high
yields,
compatibility
are
advantages
this
protocol.
Mini-Reviews in Organic Chemistry,
Год журнала:
2022,
Номер
20(4), С. 358 - 371
Опубликована: Май 20, 2022
Abstract:
2-pyridones
represents
ubiquitous
scaffolds
often
present
in
both
natural
products
and
pharmaceutical
compounds.
Due
to
their
wide
applications
medicinal
chemistry,
it
is
not
surprising
that
the
synthesis
of
2-pyridone
derivatives
has
attracted
organic
chemists
for
many
years.
This
mini
review
focuses
on
recent
development
multi-component
period
2011
2021,
particularly
those
involve
three/four
component
reactions
activated
methylene,
aldehyde
or
ketone
withdifferent
intermediate
materials
under
different
conditions.
Asian Journal of Organic Chemistry,
Год журнала:
2022,
Номер
11(3)
Опубликована: Янв. 26, 2022
Abstract
In
this
study,
a
concise
and
efficient
protocol
for
the
construction
of
diverse
cyclohexanedione‐fused
2,8‐oxaza/2,8‐dioxa
bicyclo[3.3.1]nonanes
4‐substituted
4
H
‐chromenes
between
2‐hydroxychalcones
3‐aminocyclohex‐2‐enones
has
been
accomplished.
This
switchable
synthesis
concerning
three
types
functionalized
heterocyclics
via
tunability
deamination/dehydration
process
was
controlled
by
Brønsted
acid
catalyst
or
solvent
effects
in
cascade
transformation,
which
can
thus
provide
desired
products
good
to
excellent
yields.
Letters in Organic Chemistry,
Год журнала:
2024,
Номер
22(1), С. 61 - 69
Опубликована: Май 29, 2024
<i>β</i>-(<i>N</i>-arylamino)acrylates
are
building
blocks
of
great
industrial
interest
as
they
allow
the
obtention
a
variety
heterocyclic
substances,
such
quinoline
and
pyridone
derivatives.
Therefore,
development
new
methodologies
for
synthesis
these
substances
is
still
interest.
In
this
work,
fourteen
were
synthesized
in
multigram
scale
from
reaction
mono-
di-substituted
anilines
with
diethyl
ethoxymethylenemalonate
by
sonochemistry
(US)
results
compared
to
those
obtained
conventional
heating.
The
use
US
brought
many
benefits
syntheses,
including
faster
reactions
increased
yields.
crystal
structure
2-(((2-chloro-5-nitrophenyl)amino)methylene)malonate
also
reported.
