Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection

Angewandte Chemie International Edition, Год журнала: 2020, Номер 60(30), С. 16294 - 16308

Опубликована: Авг. 12, 2020

The development of fluorophores for the second near-infrared window (NIR-II, 1000-1700 nm) represents an emerging, significant, and vibrant field in analytic chemistry, chemical biology, biomedical engineering. wavelength, brightness, stability are three crucial factors that determine performance NIR-II fluorophore. Up to now, significant progress has been made fluorescence molecular probes, including synthesis D-A-D D-π-A with improved imaging construction off-on probes ratiometric via energy transfer or structure modification. In this review, we summarize most recent advances engineering design strategies then highlight a selection bioimaging biosensing applications. We also provide perspectives on potential challenges opportunities emerging field.

Язык: Английский

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Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Chemical Reviews, Год журнала: 2021, Номер 122(1), С. 209 - 268

Опубликована: Окт. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Язык: Английский

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Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy

Chemical Society Reviews, Год журнала: 2022, Номер 51(21), С. 8957 - 9008

Опубликована: Янв. 1, 2022

We discuss recent advances made in the development of NIR fluorescence-emitting small organic molecules for tumor imaging and therapy.

Язык: Английский

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The Chemistry of Organic Contrast Agents in the NIR‐II Window

Angewandte Chemie International Edition, Год журнала: 2021, Номер 61(14)

Опубликована: Дек. 7, 2021

Abstract Optical imaging, especially fluorescence and photoacoustic is a non‐invasive imaging approach with high spatial temporal resolution sensitivity, compared to positron emission tomography (PET) or magnetic resonance (MRI). Due the merits of using second near‐infrared (NIR‐II) window, like deeper penetration depth, signal‐to‐noise ratio, resolution, low tissue damage, researchers have devoted great effort developing contrast agents NIR‐II absorption emission. In this Review, we summarize recently developed organic luminescent materials, ranging from small molecules conjugated polymers. Then, systematically introduce engineering strategies describe performance classified by skeleton cores. Finally, elucidate challenges prospects these dyes for potential clinical applications. We expect our summary can inspire expand spectrum diverse bioapplications.

Язык: Английский

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Recent advances in the development of NIR-II organic emitters for biomedicine

Coordination Chemistry Reviews, Год журнала: 2020, Номер 415, С. 213318 - 213318

Опубликована: Апрель 9, 2020

Язык: Английский

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ROS/RNS and Base Dual Activatable Merocyanine‐Based NIR‐II Fluorescent Molecular Probe for in vivo Biosensing

Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(50), С. 26337 - 26341

Опубликована: Окт. 4, 2021

Inflammation usually results in high-level reactive oxygen species (ROS) and nitrogen (RNS) not only acidic tissue but also alkaline tissue. However, noninvasively vivo monitoring specifically within remains a huge challenge. Here we introduce dual activatable fluorescent probe PN910 located the second near-infrared window (NIR-II, 900-1700 nm), which shows high selectivity toward H2 O2 OONO- at pH beyond 7.4. Then verified that could be used for real-time, specific accurate of cystitis colitis living animals. This report presents unique approach to development biosensing.

Язык: Английский

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Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

The Innovation, Год журнала: 2021, Номер 2(1), С. 100082 - 100082

Опубликована: Янв. 19, 2021

Phototheranostics integrates deep-tissue imaging with phototherapy (containing photothermal therapy and photodynamic therapy), holding great promise in early diagnosis precision treatment of cancers. Recently, second near-infrared (NIR-II) fluorescence exhibits the merits high accuracy specificity, as well real-time detection. Among NIR-II fluorophores, organic small molecular fluorophores have shown superior properties biocompatibility, variable structure, tunable emission wavelength than inorganic materials. What's more, some also display excellent cytotoxicity when illuminated NIR laser. This review summarizes progress different central cores for cancer phototheranostics past few years, focusing on structures phototheranostic performances. Furthermore, challenges prospects future development toward clinical translation are discussed.

Язык: Английский

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Design of NIR-II high performance organic small molecule fluorescent probes and summary of their biomedical applications

Coordination Chemistry Reviews, Год журнала: 2022, Номер 468, С. 214609 - 214609

Опубликована: Май 31, 2022

Язык: Английский

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An ER‐targeted, Viscosity‐sensitive Hemicyanine Dye for the Diagnosis of Nonalcoholic Fatty Liver and Photodynamic Cancer Therapy by Activating Pyroptosis Pathway

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(9)

Опубликована: Янв. 10, 2024

The concept of molecular design, integrating diagnostic and therapeutic functions, aligns with the general trend modern medical advancement. Herein, we rationally designed smart molecule ER-ZS for endoplasmic reticulum (ER)-targeted diagnosis treatment in cell animal models by combining hemicyanine dyes ER-targeted functional groups (p-toluenesulfonamide). Owing to its ability target ER a highly specific response viscosity, demonstrated substantial fluorescence turn-on only after binding ER, independent other physiological environments. In addition, ER-ZS, being small molecule, allows nonalcoholic fatty liver disease (NAFLD) via imaging based on high stress. Importantly, is type I photosensitizer, producing O

Язык: Английский

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Tracking tumor heterogeneity and progression with near‐infrared II fluorophores

Exploration, Год журнала: 2023, Номер 3(2)

Опубликована: Март 16, 2023

Abstract Heterogeneous cells are the main feature of tumors with unique genetic and phenotypic characteristics, which can stimulate differentially progression, metastasis, drug resistance. Importantly, heterogeneity is pervasive in human malignant tumors, identification degree tumor individual progression a critical task for treatment. However, current medical tests cannot meet these needs; particular, need noninvasive visualization single‐cell heterogeneity. Near‐infrared II (NIR‐II, 1000–1700 nm) imaging exhibits an exciting prospect non‐invasive monitoring due to high temporal‐spatial resolution. More importantly, NIR‐II displays more extended tissue penetration depths reduced backgrounds because significantly lower photon scattering autofluorescence than traditional near‐infrared I (NIR‐I) imaging. In this review, we summarize systematically advances made imaging, especially detection as well As visual inspection modality, shows promising prospects understanding differences envisioned have potential be used clinically.

Язык: Английский

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