Catalysts,
Год журнала:
2021,
Номер
11(5), С. 554 - 554
Опубликована: Апрель 27, 2021
Sustainable
transformations
towards
the
production
of
valuable
chemicals
constantly
attract
interest,
both
in
terms
academic
and
applied
research.
C–H
activation
has
long
been
scrutinized
this
regard,
given
that
it
offers
a
straightforward
pathway
to
prepare
compounds
great
significance.
In
context,
directing
groups
(DG)
have
paved
way
for
chemical
had
not
achievable
using
traditional
reactions.
Few
steps,
high
yields,
selectivity
inert
substrates
are
some
invaluable
assets
directed
catalysis.
Additionally,
employment
traceless
(TDG)
greatly
improves
simplifies
strategy,
enabling
realization
multi-step
reactions
one-pot,
cascade
procedures.
Cheap,
abundant,
readily
available
transition
metal
salts
complexes
can
catalyze
plethora
employing
TDGs,
usually
under
low
catalyst
loadings—rarely
stoichiometric
amounts,
leading
greater
atom
economy
milder
conditions
with
increased
yields
step-economy.
This
review
article
summarizes
all
work
done
on
TDG-assisted
catalysis
manganese,
iron,
cobalt,
nickel,
or
copper
catalysts,
discusses
structure-activity
relationships
observed,
by
presenting
catalytic
pathways
range
reported
thus
far.
Organic Letters,
Год журнала:
2022,
Номер
24(18), С. 3395 - 3400
Опубликована: Май 5, 2022
The
transition-metal-catalyzed
C-H
functionalization
of
sulfoxonium
ylides
with
alkynes
formally
participates
in
[4
+
2]
annulations
to
deliver
the
naphthol
scaffolds.
In
contrast,
herein
we
disclose
first
Rh(III)-catalyzed
activation,
followed
by
redox-neutral
[3
annulation
1,3-diynes,
which
delivers
alkynated
indenone
derivatives.
This
protocol
features
a
good
functional
group
tolerance,
broad
substrate
scope,
moderate
excellent
yields,
and
mild
reaction
conditions.
mechanism
was
supported
through
ESI-HRMS
characterizing
key
intermediates
catalytic
cycle.
Organic Letters,
Год журнала:
2023,
Номер
25(22), С. 4022 - 4027
Опубликована: Май 26, 2023
A
novel
Rh-catalyzed
cascade
reaction
of
pyridotriazoles
with
iodonium
ylides
is
reported.
This
one-pot
procedure
involves
a
triazole-directed
ortho-position
C–H
carbene
insertion,
followed
by
intramolecular
denitrogenation
annulation.
It
was
noteworthy
that
this
provided
straightforward
access
to
1H-isochromene
frameworks
excellent
yields
(up
94%
yield).
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(23)
Опубликована: Апрель 3, 2024
Abstract
Catalytic
methods
allowing
for
the
reliable
prediction
and
control
of
diverse
regioselectivity
along
with
enantioselectivity
to
access
different
regio‐
enantiomers
by
switching
least
reaction
parameters
are
one
most
attractive
ways
in
organic
synthesis,
which
provide
enantioenriched
architectures
from
identical
starting
materials.
Herein,
a
Co‐catalyzed
regiodivergent
enantioselective
reductive
hydroalkylation
1,3‐dienes
aldehydes
has
been
achieved,
furnishing
homoallylic
alcohol
good
levels
enantioselectivity.
The
features
switch
tuned
selection
proton
source.
use
an
acid
as
source
provided
asymmetric
1,2‐hydroalkylation
products
under
conditions,
yet
4,3‐hydroalkylation
were
obtained
silane
hydride
This
catalytic
protocol
allows
alcohols
two
continuous
saturated
carbon
centers
regio‐,
diastereo‐,
ACS Catalysis,
Год журнала:
2024,
Номер
14(9), С. 6535 - 6546
Опубликована: Апрель 15, 2024
Palladium-catalyzed
C–H
annulation
reactions
represent
a
compelling
strategy
to
construct
complex
ring
systems
with
high
step
economy.
While
there
are
many
approaches
annulate
structures
by
activation
of
single
bond,
transformations
that
proceed
multiple
bonds
less
explored.
This
is
especially
true
for
examples
where
one
the
reacting
located
at
an
sp3
center.
However,
exciting
developments
in
palladium-catalyzed
continue
expand
scope
these
and
provide
innovative
strategies
challenging
carbon–carbon
bonds.
From
discoveries,
sequential
activations
have
emerged
as
powerful
tool
access
through
C(sp2)–H/C(sp3)–H
or
C(sp3)–H/C(sp3)–H
In
this
Perspective,
we
showcase
recent
use
order
highlight
synthetic
potential
activation-enabled
annulations
inspire
future
disconnections
diverse
scaffold
synthesis.
Catalysts,
Год журнала:
2021,
Номер
11(5), С. 554 - 554
Опубликована: Апрель 27, 2021
Sustainable
transformations
towards
the
production
of
valuable
chemicals
constantly
attract
interest,
both
in
terms
academic
and
applied
research.
C–H
activation
has
long
been
scrutinized
this
regard,
given
that
it
offers
a
straightforward
pathway
to
prepare
compounds
great
significance.
In
context,
directing
groups
(DG)
have
paved
way
for
chemical
had
not
achievable
using
traditional
reactions.
Few
steps,
high
yields,
selectivity
inert
substrates
are
some
invaluable
assets
directed
catalysis.
Additionally,
employment
traceless
(TDG)
greatly
improves
simplifies
strategy,
enabling
realization
multi-step
reactions
one-pot,
cascade
procedures.
Cheap,
abundant,
readily
available
transition
metal
salts
complexes
can
catalyze
plethora
employing
TDGs,
usually
under
low
catalyst
loadings—rarely
stoichiometric
amounts,
leading
greater
atom
economy
milder
conditions
with
increased
yields
step-economy.
This
review
article
summarizes
all
work
done
on
TDG-assisted
catalysis
manganese,
iron,
cobalt,
nickel,
or
copper
catalysts,
discusses
structure-activity
relationships
observed,
by
presenting
catalytic
pathways
range
reported
thus
far.
