Accessing secondary amine containing fine chemicals and polymers with an earth-abundant hydroaminoalkylation catalyst

Green Chemistry, Год журнала: 2023, Номер 25(7), С. 2629 - 2639

Опубликована: Янв. 1, 2023

Titanium-catalyzed hydroaminoalkylation has emerged as an atom-economical, earth-abundant synthesis of N-containing products.

Язык: Английский

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Ti-Catalyzed Modular Ketone Synthesis from Carboxylic Derivatives and gem-Dihaloalkanes

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(27), С. 14884 - 14893

Опубликована: Июнь 26, 2023

Ketones are ubiquitous in organic synthesis. However, the general method to convert widely available carboxylic acids, unactivated esters, and amides into ketones remains elusive. Herein, we describe Ti-catalyzed modular ketone synthesis from derivatives easily accessed gem-dihaloalkanes. Notably, this protocol could achieve direct catalytic olefination of acids. This features a sequence electrophilic transformation good functional group compatibility allows rapid access various functionalized ketones. Preliminary mechanistic studies provide insights reaction pathway support intermediacy plausible alkylidene titanocene gem-bimetallic complexes.

Язык: Английский

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Transition-Metal Catalyzed Synthesis of Pyrimidines: Recent Advances, Mechanism, Scope and Future Perspectives

Topics in Current Chemistry, Год журнала: 2024, Номер 382(1)

Опубликована: Янв. 31, 2024

Язык: Английский

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Tracking Coordination Environment and Reaction Intermediates in Homogeneous and Heterogeneous Epoxidation Catalysts via Ti L_2,3-Edge Near-Edge X-ray Absorption Fine Structures

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(11), С. 7456 - 7466

Опубликована: Март 6, 2024

Ti-based molecules and materials are ubiquitous play a major role in both homogeneous heterogeneous catalytic processes. Understanding the electronic structures of their active sites (oxidation state, local symmetry, ligand environment) is key to developing molecular-level structure-property relationships. In that context, X-ray absorption spectroscopy (XAS) offers unique combination elemental selectivity sensitivity symmetry. Commonly, for early transition metals such as Ti, K-edge XAS applied situ characterization subsequent structural analysis with high toward tetrahedral species. Ti L

Язык: Английский

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Update for Reactions of Group 4 Metallocene Bis(trimethylsilyl)acetylene Complexes: A Never-Ending Story?

Organometallics, Год журнала: 2020, Номер 39(24), С. 4403 - 4414

Опубликована: Ноя. 18, 2020

Recently reported reactions of group 4 metallocene bis(trimethylsilyl)acetylene complexes from the last two years are summarized. This could be considered as a never-ending story. A recently alternative and very straightforward method for preparation well-known alkyne complex Cp2Ti(η2-Me3SiC2SiMe3) by Beckhaus et al. in future have great effect on application this complex. Similar improvements made earlier Tilley co-workers Zr analogue Cp2Zr(py)(Me3SiC2SiMe3) enabled preparative organometallic organic chemists to establish reagent wide range coupling reactions. Examples summarized review. These similar reagents represent excellent sources yield reactive coordinatively electronically unsaturated fragments [Cp′2M]. They will potential large number interesting applications future.

Язык: Английский

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