IL-24 improves efficacy of CAR-T cell therapy by targeting stemness of tumor cells

British Journal of Cancer, Год журнала: 2024, Номер 130(8), С. 1337 - 1347

Опубликована: Фев. 12, 2024

Язык: Английский

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Targeting the glutamine-arginine-proline metabolism axis in cancer

Journal of Enzyme Inhibition and Medicinal Chemistry, Год журнала: 2024, Номер 39(1)

Опубликована: Июль 25, 2024

Metabolic abnormalities are an important feature of tumours. The glutamine-arginine-proline axis is node cancer metabolism and plays a major role in amino acid metabolism. This also acts as scaffold for the synthesis other nonessential acids essential metabolites. In this paper, we briefly review (1) glutamine addiction exhibited by tumour cells with accelerated transport metabolism; (2) methods regulating extracellular entry, intracellular fate glutamine; (3) glutamine, proline arginine metabolic pathways their interaction; (4) research progress therapy targeting system, focus on summarising therapeutic strategies one key enzymes P5CS (ALDH18A1). provides new basis treatments characteristics

Язык: Английский

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Unraveling the underlying mechanisms of cancer stem cells in therapeutic resistance for optimizing treatment strategies

MedComm – Oncology, Год журнала: 2025, Номер 4(1)

Опубликована: Янв. 10, 2025

Abstract The success of cancer therapy has been significantly hampered by various mechanisms therapeutic resistance. Chief among these is the presence clonal heterogeneity within an individual tumor mass. introduction concept stem cells (CSCs)—a rare and immature subpopulation with tumorigenic potential that contributes to intratumoral heterogeneity—has deepened our understanding drug Given characteristics CSCs, such as increased drug‐efflux activity, enhanced DNA‐repair capacity, high metabolic plasticity, adaptability oxidative stress, and/or upregulated detoxifying aldehyde dehydrogenase (ALDH) enzymes, CSCs have recognized a theoretical reservoir for resistant diseases. Implicit in this recognition possibility CSC‐targeted strategies might offer breakthrough overcoming resistance patients. Herein, we summarize generation current underlying CSC‐mediated This extended knowledge progressively translated into novel anticancer enriched available options combination treatments, all which are anticipated improve clinical outcomes patients experiencing CSC‐related relapse.

Язык: Английский

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Hyperbaric oxygen regulates tumor microenvironment and boosts commercialized nanomedicine delivery for potent eradication of cancer stem-like cells

Nano Today, Год журнала: 2021, Номер 40, С. 101248 - 101248

Опубликована: Июль 15, 2021

Язык: Английский

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Detection of atherosclerosis-associated HOCl using a mitochondria-targeted fluorescent probe

Sensors and Actuators B Chemical, Год журнала: 2021, Номер 348, С. 130695 - 130695

Опубликована: Сен. 1, 2021

Язык: Английский

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