ACS Nano,
Год журнала:
2022,
Номер
16(10), С. 15779 - 15791
Опубликована: Авг. 18, 2022
Antimicrobial
peptides
(AMPs)
constitute
a
promising
class
of
alternatives
to
antibiotics
curb
antimicrobial
resistance.
Nonetheless,
their
utility
as
systemic
agent
is
hampered
by
short
circulation
time
and
toxicity.
Infection
sites,
analogous
tumors,
harbor
an
aberrant
microenvironment
that
has
the
potential
be
exploited
develop
conditionally
activated
therapeutics
with
improved
therapeutic
index.
In
particular,
we
identified
strategies
prolong
small,
cationic
AMPs
in
mouse
model
bacterial
pneumonia.
Specifically,
report
albumin-binding
domain
(ABD)-AMP
conjugate
long-circulating
conditional
AMP
masked
activity
can
liberated
proteases
infected
tissue
microenvironment.
Our
systemically
administered
enhanced
pulmonary
delivery
active
while
also
reducing
exposure
other
off-target
organs.
Importantly,
this
reduction
safety
profile
AMP.
The
framework
present
generalized
quantify
optimize
performance
emerging
therapeutics.
Protein Science,
Год журнала:
2021,
Номер
31(1), С. 92 - 106
Опубликована: Сен. 16, 2021
Abstract
The
antimicrobial
peptide
database
(APD)
has
served
the
field
for
18
years.
Because
it
is
widely
used
in
research
and
education,
this
article
documents
milestones
key
events
that
have
transformed
into
current
form.
A
comparison
made
APD
statistics
between
2010
2020,
validating
major
findings
to
date.
We
also
describe
new
additions
ranging
from
entries
search
functions.
Of
note,
contains
peptides
host
microbiota,
which
are
important
shaping
immune
systems
could
be
linked
a
variety
of
human
diseases.
Finally,
been
re‐programmed
web
branding
latest
security
compliance
University
Nebraska
Medical
Center.
reprogrammed
can
accessed
at
https://aps.unmc.edu
.
Molecules,
Год журнала:
2022,
Номер
27(12), С. 3703 - 3703
Опубликована: Июнь 9, 2022
The
quest
for
an
extraordinary
array
of
defense
strategies
is
imperative
to
reduce
the
challenges
microbial
attacks
on
plants
and
animals.
Plant
antimicrobial
peptides
(PAMPs)
are
a
subset
(AMPs).
PAMPs
elicit
against
prevent
drug
resistance
pathogens
given
their
wide
spectrum
activity,
excellent
structural
stability,
diverse
mechanism
action.
This
review
aimed
identify
applications,
features,
production,
expression,
using
its
structure–activity
relationship.
discovery
techniques
used
these
were
also
explored
provide
insight
into
significance
in
genomics,
transcriptomics,
proteomics,
expression
disease-causing
pathogens.
creates
awareness
as
potential
therapeutic
agents
medical
pharmaceutical
fields,
such
sensitive
treatment
bacterial
fungal
diseases
others
utilization
preserving
crops
available
transgenic
methods
agronomical
field.
safe
handle
easy
recycle
with
use
proteases
convert
them
more
potent
sustainable
development.
ACS Nano,
Год журнала:
2022,
Номер
16(10), С. 15779 - 15791
Опубликована: Авг. 18, 2022
Antimicrobial
peptides
(AMPs)
constitute
a
promising
class
of
alternatives
to
antibiotics
curb
antimicrobial
resistance.
Nonetheless,
their
utility
as
systemic
agent
is
hampered
by
short
circulation
time
and
toxicity.
Infection
sites,
analogous
tumors,
harbor
an
aberrant
microenvironment
that
has
the
potential
be
exploited
develop
conditionally
activated
therapeutics
with
improved
therapeutic
index.
In
particular,
we
identified
strategies
prolong
small,
cationic
AMPs
in
mouse
model
bacterial
pneumonia.
Specifically,
report
albumin-binding
domain
(ABD)-AMP
conjugate
long-circulating
conditional
AMP
masked
activity
can
liberated
proteases
infected
tissue
microenvironment.
Our
systemically
administered
enhanced
pulmonary
delivery
active
while
also
reducing
exposure
other
off-target
organs.
Importantly,
this
reduction
safety
profile
AMP.
The
framework
present
generalized
quantify
optimize
performance
emerging
therapeutics.
