Cuproptosis: Harnessing Transition Metal for Cancer Therapy

ACS Nano, Год журнала: 2023, Номер 17(20), С. 19581 - 19599

Опубликована: Окт. 11, 2023

Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They act constituents of metalloenzymes involved cellular metabolism, function signaling molecules to regulate the proliferation metastasis tumors, are integral components metal-based anticancer drugs. Notably, recent research reveals that excessive copper can also modulate occurrence programmed cell death (PCD), known cuprotosis, cancer cells. This modulation occurs through disruption tumor metabolism induction proteotoxic stress. discovery uncovers a mode interaction between transition metals proteins, emphasizing intricate link homeostasis metabolism. Moreover, they provide innovative therapeutic strategies for precise diagnosis treatment malignant tumors. At crossroads chemistry oncology, we undertake comprehensive review elucidating molecular mechanisms underpinning cuproptosis. Additionally, summarize current nanotherapeutic approaches target cuproptosis an overview available laboratory clinical methods monitoring this process. In context emerging concepts, challenges, opportunities, emphasize significant potential nanotechnology advancement field.

Язык: Английский

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Converting CO₂ into Value‐Added Products by Cu₂O‐Based Catalysts: From Photocatalysis, Electrocatalysis to Photoelectrocatalysis

Small, Год журнала: 2023, Номер 19(19)

Опубликована: Фев. 11, 2023

Abstract Converting CO 2 into value‐added products by photocatalysis, electrocatalysis, and photoelectrocatalysis is a promising method to alleviate the global environmental problems energy crisis. Among semiconductor materials applied in catalytic reduction, Cu O has advantages of abundant reserves, low price friendliness. Moreover, unique adsorption activation properties for , which conducive generation C 2+ through CC coupling. This review introduces basic principles reduction summarizes pathways 1 products. The factors affecting performance are further discussed from perspective reaction environment, medium, novel reactor design. Then, O‐based catalysts summarized several optimization strategies enhance their stability redox capacity discussed. Subsequently, application photocatalytic, electrocatalytic, photoelectrocatalytic described. Finally, opportunities, challenges research directions field presented, guidance its wide fields provided.

Язык: Английский

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Electrochemical NO₃^– Reduction Catalyzed by Atomically Precise Ag₃₀Pd₄ Bimetallic Nanocluster: Synergistic Catalysis or Tandem Catalysis?

ACS Nano, Год журнала: 2023, Номер 17(13), С. 12747 - 12758

Опубликована: Июнь 28, 2023

Electrochemically converting NO3- compounds into ammonia represents a sustainable route to remove industrial pollutants in wastewater and produce valuable chemicals. Bimetallic nanomaterials usually exhibit better catalytic performance than the monometallic counterparts, yet unveiling reaction mechanism is extremely challenging. Herein, we report an atomically precise [Ag30Pd4 (C6H9)26](BPh4)2 (Ag30Pd4) nanocluster as model catalyst toward electrochemical reduction (eNO3-RR) elucidate different role of Ag Pd site unveil comprehensive mechanism. Ag30Pd4 homoleptic alkynyl-protected superatom with 2 free electrons, it has metal core where 4 atoms are located at subcenter core. Furthermore, exhibits excellent eNO3-RR robust stability for prolonged operation, can achieve highest Faradaic efficiency NH3 over 90%. In situ Fourier-transform infrared study revealed that plays more critical NO2-, while makes major contribution catalyze NO2- NH3. The bimetallic adopts tandem rather synergistic effect eNO3-RR. Such finding was further confirmed by density functional theory calculations, they disclosed most preferable binding NO3-, which then binds water molecule release NO2-. Subsequently, transfer vicinal exposed promote formation.

Язык: Английский

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Clinical applications and therapeutic potentials of advanced nanoparticles: a comprehensive review on completed human clinical trials

Frontiers in Nanotechnology, Год журнала: 2024, Номер 6

Опубликована: Окт. 21, 2024

Nanoparticles are attractive therapeutic tools due to their distinctive characteristics, including more accurate drug delivery, improved bioavailability, and enhanced targeted therapy. This review offers a comprehensive analysis of the potentials cutting-edge nanoparticles as demonstrated in human clinical trials, based on empirical evidence. Through systematic searches major scientific databases, relevant studies published up March 2024 were included, focusing trials utilizing advanced for purposes. The discusses diverse applications oncology, infectious diseases, neurology, other medical fields. Additionally, it scrutinizes safety profiles, efficacy outcomes, challenges associated with nanoparticle-based therapies. findings underscore significant progress translating nanoparticle research into practice highlight potential these innovative platforms revolutionize treatments. contributes valuable insights growing field therapeutics, fostering deeper understanding implications practice.

Язык: Английский

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Silver nanoparticles immobilized on crosslinked vinyl polymer for catalytic reduction of nitrophenol: experimental and computational studies

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 3, 2025

Язык: Английский

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Modification engineering over single-atom catalysts for efficient heterogeneous photocatalysis

Coordination Chemistry Reviews, Год журнала: 2025, Номер 529, С. 216468 - 216468

Опубликована: Янв. 21, 2025

Язык: Английский

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Purifying water with silver nanoparticles (AgNPs)-incorporated membranes: Recent advancements and critical challenges

Water Research, Год журнала: 2022, Номер 222, С. 118901 - 118901

Опубликована: Июль 28, 2022

Язык: Английский

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A review on the synthesis and applications of sustainable copper-based nanomaterials

Green Chemistry, Год журнала: 2022, Номер 24(9), С. 3502 - 3573

Опубликована: Янв. 1, 2022

A comprehensive review of the synthesis and applications Cu Cu-based nanomaterials. variety including organic reactions, photocatalysis, environmental remediation, sensors have been included.

Язык: Английский

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Biogenic adsorbents for removal of drugs and dyes: A comprehensive review on properties, modification and applications

Chemosphere, Год журнала: 2023, Номер 338, С. 139477 - 139477

Опубликована: Июль 11, 2023

This comprehensive review explores the potential and versatility of biogenic materials as sustainable environmentally benign alternatives to conventional adsorbents for removal drugs dyes. Biogenic derived from plants, animals, microorganisms, algae biopolymers have bioactive compounds that interact with functional groups pollutants, resulting in their binding sorbent. These can be modified mechanically, thermally chemically enhance adsorption properties. hybrid composites, which integrate characteristics more than one material, also been fabricated. Additionally, microorganisms are analyzed ability uptake pollutants. Various influential factors contribute process discussed. The challenge, limitations future prospects research reviewed bridging gap between large scale application laboratory scale. review, involves a combination various adsorbents, going beyond existing literature where typically only specific reported. covers isotherms, kinetics, desorption studies providing an improved framework effective use removing pharmaceuticals dyes wastewater.

Язык: Английский

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Nanomaterials-based fluorescent assays for pathogenic bacteria in food-related matrices

Trends in Food Science & Technology, Год журнала: 2023, Номер 142, С. 104214 - 104214

Опубликована: Окт. 23, 2023

Язык: Английский

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