Physical review. A/Physical review, A,
Год журнала:
2024,
Номер
110(2)
Опубликована: Авг. 22, 2024
Here
it
is
shown
that
the
exciton
interactions
within
organic
dye
aggregates,
as
modeled
by
Frenkel
Hamiltonian,
enable
construction
of
an
on-off
switchable
gate.
In
this
construction,
a
single
residing
on
controlling
gate
molecule
may
pass
or
inhibit
ballistic
propagation
in
proximal
channel
consisting
array
molecules.
High
ratios
excess
${10}^{2}$
can
be
achieved
through
use
static
difference
dipole-dipole
between
and
which
effectively
creates
Bragg
grating.
The
exhibit
entanglement
with
quantum-mechanical
superposition
presence
absence
occupation
molecule.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(9), С. 3687 - 3697
Опубликована: Фев. 14, 2024
DNA
nanotechnology
is
rapidly
gaining
traction
in
numerous
applications,
each
bearing
varying
degrees
of
tolerance
to
the
quality
and
quantity
necessary
for
viable
nanostructure
function.
Despite
distinct
objectives
application,
they
are
united
their
reliance
on
essential
analytical
techniques,
such
as
purification
characterization.
This
tutorial
aims
guide
reader
through
current
state
chemistry,
outlining
important
factors
consider
when
designing,
assembling,
purifying,
characterizing
a
downstream
applications.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(26), С. 10669 - 10676
Опубликована: Июнь 24, 2024
DNA
walker,
a
type
of
dynamic
device
that
is
capable
moving
progressively
along
prescribed
walking
tracks,
has
emerged
as
an
ideal
and
powerful
tool
for
biosensing
bioimaging.
However,
most
the
reported
three-dimensional
(3D)
walker
were
merely
designed
detection
single
target,
they
not
achieving
universal
applicability.
Herein,
we
first
time
development
proximity-induced
3D
bipedal
imaging
low
abundance
biomolecules.
As
proof
concept,
miRNA-34a,
biomarker
breast
cancer,
chosen
model
system
to
demonstrate
this
approach.
In
our
design,
can
be
generated
only
by
specific
recognition
two
proximity
probes
miRNA-34a.
Meanwhile,
it
stochastically
autonomously
traveled
on
tracks
(gold
nanoparticles)
via
catalytic
hairpin
assembly
(CHA),
resulting
in
amplified
fluorescence
signal.
comparison
with
some
conventional
walkers
utilized
living
cell
imaging,
induced
ligation
assay
greatly
improve
ensure
high
selectivity
bioanalysis.
By
taking
advantage
these
unique
features,
successfully
realizes
accurate
effective
monitoring
target
miRNA-34a
expression
levels
cells,
affording
universal,
valuable,
promising
platform
low-abundance
cancer
identification
cancer.
The Journal of Physical Chemistry Letters,
Год журнала:
2025,
Номер
unknown, С. 2468 - 2478
Опубликована: Фев. 28, 2025
Light-harvesting
antenna
systems
(AS)
with
multiple
light-absorbing
chromophores
play
a
vital
role
in
absorbing
sunlight
and
transferring
the
excitation
energy
to
reaction
centers
during
photosynthesis
process.
Learning
from
nature,
set
of
simple
artificial
pyrene-based
light-harvesting
have
been
designed
re-examined
self-developing
chemical
intermediates,
via
combining
electron-donating
4,4-dimethoxy-triphenylamine
moieties
as
for
donors
center.
These
exhibit
positive
correlation
between
molar
absorption
coefficient
(ε),
enhanced
photoluminescence
efficiency
unchanged
emission
peak,
two-photon
cross-section
an
increasing
number
TPA-OMe
solution.
Moreover,
excited-state
dynamics
these
AS
indicated
that
coexistence
charge
transfer
(CT)
state
separation
(CS)
plays
significant
affecting
behavior.
The
short-lived
CS
was
affected
by
increased
low
polar
solvent,
which
can
boost
decay
recombination
(CR),
resulting
emission.
On
contrary,
long-lived
would
overwhelm
CT
high
solvent
or
molecules
containing
one
two
units.
Communications Chemistry,
Год журнала:
2024,
Номер
7(1)
Опубликована: Фев. 29, 2024
Peptide-based
liquid-liquid
phase
separated
domains,
or
coacervates,
are
a
biomaterial
gaining
new
interest
due
to
their
exciting
potential
in
fields
ranging
from
biosensing
drug
delivery.
In
this
study,
we
demonstrate
that
coacervates
provide
simple
and
biocompatible
medium
improve
nucleic
acid
biosensors
through
the
sequestration
of
both
biosensor
target
strands
within
coacervate,
thereby
increasing
local
concentration.
Using
well-established
polyarginine
(R
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(17), С. 22334 - 22343
Опубликована: Апрель 18, 2024
The
number
of
applications
self-assembled
deoxyribonucleic
acid
(DNA)
origami
nanoparticles
(DNA
NPs)
has
increased
drastically,
following
the
development
a
variety
single-stranded
template
DNA
(ssDNA)
that
can
serve
as
scaffold
strand.
In
addition
to
viral
genomes,
such
M13
bacteriophage
and
lambda
DNAs,
enzymatically
produced
ssDNA
from
various
sources
is
rapidly
gaining
traction
being
applied
for
NP
preparation.
However,
separating
fully
formed
NPs
have
custom
scaffolds
crude
assembly
mixes
often
multistep
process
first
its
enzymatic
amplification
then
isolating
assembled
excess
precursor
strands.
Only
sample
ready
downstream
characterization
application.
this
work,
we
highlight
single-step
purification
sequence-
or
M13-derived
scaffold-based
using
photocleavable
biotin
tethers.
only
requires
an
inexpensive
ultraviolet
(UV)
lamp,
with
up
90%
yield
high
purity
are
obtained.
We
show
versatility
in
two
multihelix
bundle
structures
wireframe
polyhedral
architecture.
Abstract
DNA
nanostructures
offer
a
versatile
platform
for
precise
dye
assembly,
making
them
promising
templates
creating
photonic
complexes
with
applications
in
photonics
and
bioimaging.
However,
despite
these
advancements,
the
effect
of
loading
on
hybridization
kinetics
single‐stranded
protruding
from
remains
unexplored.
In
this
study,
points
accumulation
imaging
nanoscale
topography
(DNA‐PAINT)
technique
is
employed
to
investigate
accessibility
functional
binding
sites
DNA‐templated
excitonic
wires.
The
results
indicate
that
positively
charged
dyes
frameworks
can
accelerate
protruded
ssDNA
through
long‐range
electrostatic
interactions.
Furthermore,
impacts
various
are
explored
diverse
varying
cross‐sizes.
research
underscores
crucial
role
interactions
within
DNA‐dye
complexes,
offering
valuable
insights
functionalization
assembly
biomimetic
systems.
Molecules,
Год журнала:
2024,
Номер
29(1), С. 267 - 267
Опубликована: Янв. 4, 2024
As
an
important
barrier
between
the
cytoplasm
and
microenvironment
of
cell,
cell
membrane
is
essential
for
maintenance
normal
cellular
physiological
activities.
An
abnormal
a
crucial
symbol
body
dysfunction
occurrence
variant
diseases;
therefore,
visualization
monitoring
biomolecules
associated
with
membranes
disease
markers
are
utmost
importance
in
revealing
biological
functions
membranes.
Due
to
their
biocompatibility,
programmability,
modifiability,
DNA
nanomaterials
have
become
increasingly
popular
fluorescence
imaging
recent
years.
In
addition,
can
be
combined
specific
manner
enable
real-time
signal
molecules
on
membrane,
allowing
progression.
This
article
examines
application
First,
we
present
conditions
microenvironment,
such
as
ATP,
pH,
etc.
Second,
summarize
applications
receptors
other
molecules.
Finally,
some
difficulties
challenges
presented.
Langmuir,
Год журнала:
2024,
Номер
40(19), С. 10195 - 10207
Опубликована: Май 1, 2024
With
recent
advances
in
DNA-templated
dye
aggregation
for
leveraging
and
engineering
molecular
excitons,
a
need
exists
minimizing
structural
heterogeneity.
Holliday
Junction
complexes
(HJ)
are
commonly
used
to
covalently
template
aggregates
on
their
core;
however,
the
global
conformation
of
HJ
is
detrimentally
dynamic.
Here,
selectively
tuned
by
restricting
its
position
orientation
using
sheet-like
DNA
origami
construct
(DOC)
physisorbed
glass.
The
arms
fixed
with
four
different
designed
interduplex
angles
(IDAs).
Atomic
force
microscopy
confirmed
that
HJs
bound
surface
DOC
IDAs.
Dye
distributions
were
determined
combining
dipole
imaging
super-resolution
microscopy.
All
IDAs
led
orientations
having
dispersed
along
planes
perpendicular
plane,
suggesting
stacking
occurred
between
neighboring
bases.
dye-base
interpretation
was
supported
increasing
size
core
cavity.
narrowest
IDA
minimizes
heterogeneity
suggests
intercalation.
A
strong
correlation
found
plane.
These
results
show
imposes
restrictions
dye-DNA
interactions
always
present
regardless
conformation.
implications
our
discussed
scalability
self-assembly.
Our
methodology
provides
an
avenue
solid-supported
single-molecule
characterization
assemblies
templated
biomolecules─such
as
protein
templates
involved
light-harvesting
catalysis─with
conformations
restricted
orientation.
Biomaterials Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
We
investigated
the
role
of
dichloro-squaraine
(SQ)
dye
aggregates
in
facilitating
thymine–thymine
interstrand
photo-crosslinking
double
crossover
(DX)
tiles
to
improve
thermal
and
structural
stability
two-dimension
DNA-based
nanostructures.
