Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine

ACS Nano, Год журнала: 2023, Номер 17(9), С. 7979 - 8003

Опубликована: Апрель 27, 2023

Tumoricidal photodynamic (PDT) and photothermal (PTT) therapies harness light to eliminate cancer cells with spatiotemporal precision by either generating reactive oxygen species or increasing temperature. Great strides have been made in understanding biological effects of PDT PTT at the cellular, vascular tumor microenvironmental levels, as well translating both modalities clinic. Emerging evidence suggests that may synergize due their different mechanisms action, nonoverlapping toxicity profiles make such combination potentially efficacious. Moreover, PDT/PTT combinations gained momentum recent years development multimodal nanoplatforms simultaneously incorporate photodynamically- photothermally active agents. In this review, we discuss how combining can address limitations each modality alone enhance treatment safety efficacy. We provide an overview literature featuring dual nanoparticles analyze strengths various nanoparticle design strategies. also detail sequence dose affect cellular states, pathophysiology drug delivery, ultimately shaping response. Lastly, common experimental pitfalls complicate preclinical assessment propose rational guidelines elucidate underlying interactions.

Язык: Английский

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Engineered exosomes from different sources for cancer-targeted therapy

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Март 15, 2023

Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient therapeutic tool for various diseases. Engineered exosomes are the sort modified with surface decoration and internal molecules. After appropriate modification, engineered able to deliver antitumor drugs tumor sites efficiently precisely fewer treatment-related adverse effects. However, there still exist many challenges clinical translation exosomes. For instance, what sources modification strategies could endow most activity poorly understood. Additionally, how choose appropriately in different therapies another unresolved problem. In this review, we summarized characteristics exosomes, especially spatial temporal properties. concluded recent advances cancer fields, including sources, isolation technologies, strategies, labeling imaging methods Furthermore, applications were summarized, such photodynamic therapy, gene immunotherapy. Consequently, above provides researchers community latest ideas on exosome new direction drug development, prospective accelerate cancer-targeted therapy.

Язык: Английский

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Photocatalytic Superoxide Radical Generator that Induces Pyroptosis in Cancer Cells

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(25), С. 11326 - 11337

Опубликована: Июнь 16, 2022

Pyroptosis, a newly characterized form of immunogenic cell death, is attracting increasing attention as promising approach to cancer immunotherapy. However, biocompatible strategies activate pyroptosis remain rare. Here, we show that photocatalytic superoxide radical (O2-•) generator, NI-TA, triggers in cells. NI-TA was designed take advantage an intramolecular triplet-ground state splitting energy modulation approach. Detailed studies revealed the triggered by under conditions photoexcitation proceeds through caspase-3/gasdermin E (GSDME) pathway rather than via canonical processes involving caspase-1/gasdermin-D (GSDMD). found function partial-O2-recycling mode action and trigger provide for effective ablation even hypoxia (≤2% O2). In case T47D 3D multicellular spheroids, good antitumor efficiency stemness inhibition are achieved. This work highlights how chemistry may be leveraged develop pyroptosis-inducing agents.

Язык: Английский

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The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy

Chemical Society Reviews, Год журнала: 2023, Номер 52(3), С. 879 - 920

Опубликована: Янв. 1, 2023

This tutorial review provides a general overview for the design of prodrugs and activatable phototherapeutics which enables development improved therapies.

Язык: Английский

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Copper Doped Carbon Dots for Addressing Bacterial Biofilm Formation, Wound Infection, and Tooth Staining

ACS Nano, Год журнала: 2022, Номер 16(6), С. 9479 - 9497

Опубликована: Июнь 17, 2022

Oral infectious diseases and tooth staining, the main challenges of dental healthcare, are inextricably linked to microbial colonization formation pathogenic biofilms. However, dentistry has so far still lacked simple, safe, universal prophylactic options therapy. Here, we report copper-doped carbon dots (Cu-CDs) that display enhanced catalytic (catalase-like, peroxidase-like) activity in oral environment for inhibiting initial bacteria (Streptococcus mutans) adhesion subsequent biofilm eradication without impacting surrounding tissues via oxygen (O2) reactive species (ROS) generation. Especially, Cu-CDs exhibit strong affinity lipopolysaccharides (LPS) peptidoglycans (PGN), thus conferring them with excellent antibacterial ability against Gram-positive (Staphylococcus aureus) Gram-negative (Escherichia coli), such they can prevent wound purulent infection promoting rapid healing. Additionally, Cu-CDs/H2O2 system shows a better performance whitening, compared results obtained other alternatives, e.g., CDs clinically used H2O2, particularly its negligible enamel dentin destruction. It is anticipated biocompatible presented this work promising nano-mouthwash eliminating biofilms, prompting healing as well highlighting their significance health management.

Язык: Английский

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A host–guest strategy for converting the photodynamic agents from a singlet oxygen generator to a superoxide radical generator

Chemical Science, Год журнала: 2022, Номер 13(20), С. 5951 - 5956

Опубликована: Янв. 1, 2022

A supramolecular strategy is reported for converting the conventional photodynamic agents from a singlet oxygen generator to superoxide radical by host–guest interaction enhanced electron transfer.

Язык: Английский

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From Low to No O₂-Dependent Hypoxia Photodynamic Therapy (hPDT): A New Perspective

Accounts of Chemical Research, Год журнала: 2022, Номер 55(22), С. 3253 - 3264

Опубликована: Ноя. 2, 2022

ConspectusThe advent of photochemical techniques has revolutionized the landscape biology and medical sciences. Especially appealing in this context is photodynamic therapy (PDT), which a photon-initiated treatment modality that uses cytotoxic reactive oxygen species (ROS) to kill malignant cells. In past decade, PDT risen forefront cancer therapy. Its optical control enables noninvasive spatiotemporal manipulation process, its photoactive nature allows unique patterns avoid drug resistance conventional chemotherapeutics. However, despite impressive advances field, achieving widespread clinical adoption remains difficult. A major concern hostile tumor microenvironment, cells are hypoxic, hinders ROS generation during action. To overcome "Achilles' heel", current strategies focus primarily on improvement intratumoral O2 perfusion, while trials suggest enrichment may promote cell proliferation metastasis, thereby making FDA approval transformation these paradigms challenging.In an effort improve hypoxia (hPDT) clinic, we have explored "low no O2-dependent" approaches over years combat hypoxia-induced resistance. Account, present our contributions theme 5 years, beginning with low O2-dependent (e.g., type I superoxide radical (O2•–) generator, O2-economizer, mitochondrial respiration inhibition, cellular self-protective pathway modulation, etc.) progressing O2-independent autoadaptive PDT/PTT complementary therapy, artificial photoredox catalysis cells). These studies attracted tremendous attention. Particularly pioneering work 2018, presented first demonstration O2•–-mediated partial O2-recyclability mechanism can ( J. Am. Chem. Soc. 140, 14851−14859). This launched era renewed interest PDT, resulting plethora new O2•– photogenerators developed by many groups around world. Moreover, discovery reactions living cells, emerged as field connecting photochemistry biomedicine, stimulating development next-generation phototherapeutic tools 2022, 144, 163−173). Our recent also disclosed "photoredox cells" might be general action Proc. Natl. Acad. Sci. U.S.A. 119, e2210504119). emergent concepts, molecular designs, mechanisms, applications diagnosis therapeutics, well pros cons, discussed depth Account. It expected date will use researchers inspire future efforts identify more promising hPDT better meet needs

Язык: Английский

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Porous organic polymers for drug delivery: hierarchical pore structures, variable morphologies, and biological properties

Biomaterials Science, Год журнала: 2022, Номер 10(19), С. 5369 - 5390

Опубликована: Янв. 1, 2022

Porous organic polymers have received considerable attention in recent years because of their applicability as biomaterials.

Язык: Английский

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Engineering of BODIPY-based theranostics for cancer therapy

Coordination Chemistry Reviews, Год журнала: 2022, Номер 476, С. 214908 - 214908

Опубликована: Ноя. 7, 2022

Язык: Английский

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Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Авг. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Язык: Английский

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