Abstract
A
potent
palladium(II)
metal
complex
incorporating
1‐isopropyl‐1H‐perimidine‐2(3
H
)‐thione
ligand
with
structural
formula
C
32
28
ClN
2
PPdS
has
been
investigated.
Several
characterization
tools
have
employed
to
analyze
the
and
ligand,
including
single‐crystal
X‐ray
diffraction
(SCXRD),
FTIR,
NMR.
According
single
crystal
diffraction,
palladium
crystallize
in
C1
2/c1
P1
1
/n1
space
groups,
respectively,
Pd(II)
a
square
planar
geometry.
It
was
examined
how
well
catalyzed
Suzuki–Miyaura
cross‐coupling
reaction
reduction
of
nitroarenes.
The
findings
revealed
that
exhibited
exceptional
catalytic
activity
transforming
nitroarenes
into
aromatic
primary
amines
generating
biaryls
impressive
yields.
use
stoichiometric
investigations
led
hypothesis
plausible
mechanism.
Mechanochemical
transformations
have
made
chemists
enter
unknown
territories,
forcing
a
different
chemistry
perspective.
While
questioning
or
revisiting
familiar
concepts
belonging
to
solution
chemistry,
mechanochemistry
has
broken
new
ground,
especially
in
the
panorama
of
organic
synthesis.
Not
only
does
it
foster
"thinking
outside
box",
but
also
opened
reaction
paths,
allowing
overcome
weaknesses
traditional
exactly
where
use
well-established
solution-based
methodologies
rules
out
progress.
In
this
Review,
reader
is
introduced
an
intriguing
research
subject
not
yet
fully
explored
and
waiting
for
improved
understanding.
Indeed,
study
mainly
focused
on
that,
although
impossible
solution,
become
possible
under
mechanochemical
processing
conditions,
simultaneously
entailing
innovation
expanding
chemical
space.
Chemical Reviews,
Год журнала:
2023,
Номер
123(9), С. 5297 - 5346
Опубликована: Янв. 10, 2023
The
combination
of
metal-,
photo-,
enzyme-,
and/or
organocatalysis
provides
multiple
synthetic
solutions,
especially
when
the
creation
chiral
centers
is
involved.
Historically,
enzymes
and
transition
metal
species
have
been
exploited
simultaneously
through
dynamic
kinetic
resolutions
racemates.
However,
more
recently,
linear
cascades
appeared
as
elegant
solutions
for
preparation
valuable
organic
molecules
combining
bioprocesses
metal-catalyzed
transformations.
Many
advantages
are
derived
from
this
symbiosis,
although
there
still
bottlenecks
to
be
addressed
including
successful
coexistence
both
catalyst
types,
need
compatible
reaction
media
mild
conditions,
or
minimization
cross-reactivities.
Therefore,
here
also
provided
by
means
coimmobilization,
compartmentalization
strategies,
flow
chemistry,
etc.
A
comprehensive
review
presented
focusing
on
period
2015
early
2022,
which
has
divided
into
two
main
sections
that
comprise
first
use
metals
independent
catalysts
but
working
in
an
orchestral
sequential
manner,
later
their
application
bionanohybrid
materials
coimmobilization
adequate
supports.
Each
part
classified
different
subheadings,
based
catalyzed
catalyst,
while
development
nonasymmetric
stereoselective
processes
was
considered
section.
This
study
introduces
a
novel
method
for
functionalizing
natural
asphalt,
presenting
new
opportunities
upgrading
asphaltenes
from
road
to
catalyst.
The
process
utilizes
metal-free
sonobromination
technique
in
acetic
acid
incorporate
carbon-halogen
substituents
onto
asphalt.
These
sites
are
then
targeted
by
nucleophilic
substitution
with
diethanolamine,
followed
complexation
Pd(0)
create
unique
palladium
complex
grafted
stabilized
serves
as
heterogeneous
and
recoverable
catalyst
the
Suzuki
reaction.
facilitates
reaction
between
aryl
boronic
acids
various
Chemical Communications,
Год журнала:
2021,
Номер
57(83), С. 10842 - 10866
Опубликована: Янв. 1, 2021
Owing
to
the
market
competitiveness
and
urgent
societal
need,
an
optimum
speed
of
drug
discovery
is
important
criterion
for
successful
implementation.
Despite
rapid
ascent
artificial
intelligence
computational
bioanalytical
techniques
accelerate
in
big
pharma,
organic
synthesis
privileged
scaffolds
predicted
silico
vitro
vivo
studies
still
considered
as
rate-limiting
step.
C-H
activation
latest
technology
added
into
chemist's
toolbox
construction
late-stage
modification
functional
molecules
achieve
desired
chemical
physical
properties.
Particularly,
elimination
prefunctionalization
steps,
exceptional
group
tolerance,
complexity-to-diversity
oriented
synthesis,
functionalization
medicinal
expand
space.
It
has
immense
potential
a
library
molecules,
structural
required
pharmacological
properties
such
absorption,
distribution,
metabolism,
excretion,
toxicology
(ADMET)
attachment
reporters
proteome
profiling,
metabolite
etc.
preclinical
studies.
Although
heterocycle
modification,
18F
labelling,
methylation,
via
have
been
reviewed
from
synthetic
standpoint,
general
overview
these
protocols
aspects
not
reviewed.
In
this
feature
article,
we
will
discuss
recent
trends
methodologies
through
activation/annulation
cascade;
arylation
sp2-sp2
sp2-sp3
cross-coupling;
borylation/silylation
introduce
linchpin
further
manipulation;
amination
N-heterocycles
hydrogen
bond
acceptors;
fluorination/fluoroalkylation
tune
polarity
lipophilicity;
methylation:
methyl
magic
discovery;
peptide
macrocyclization
therapeutics
biologics;
fluorescent
labelling
radiolabelling
bioimaging;
bioconjugation
biology
studies;
drug-metabolite
biodistribution
excretion
diversification
drug-molecules
increase
efficacy
safety;
cutting-edge
DNA
encoded
improved
chemistry
discovery.
RSC Advances,
Год журнала:
2022,
Номер
12(21), С. 13523 - 13534
Опубликована: Янв. 1, 2022
Waste
recycling
and
the
use
of
recyclable
available
catalysts
are
important
principles
in
green
chemistry
science
industrial
research.
Therefore
this
study,
biochar
nanoparticles
were
prepared
from
biomass
pyrolysis.
Then,
they
magnetized
with
nickel
to
improve
their
recycling.
Further,
magnetic
(biochar-Ni
MNPs)
modified
by
dithizone
ligand
then
applied
for
fabrication
a
ruthenium
catalyst
(Ru-dithizone@biochar-Ni
MNPs).
This
nanocatalyst
was
characterized
high-resolution
transmission
electron
microscopy
(HRTEM),
scanning
(SEM),
energy-dispersive
X-ray
spectroscopy
(EDS),
wavelength
dispersive
(WDX),
N
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(18)
Опубликована: Фев. 6, 2023
Abstract
The
combination
of
catalytic
methods
provides
multiple
advantages
in
organic
synthesis,
allowing
access
to
diverse
molecules
a
straightforward
manner.
Merging
metal
and
enzyme
catalysis
is
currently
receiving
great
attention
due
the
possibility
assemble
C−C
coupling,
olefin
metathesis,
hydration
other
reactions
with
exquisite
stereospecificity
displayed
by
enzymes.
Thus,
this
minireview
organized
based
on
action
species
(Pd,
Ru,
Au,
Ir,
Fe…)
different
Special
will
be
paid
design
sequential
processes
concurrent
cascades,
presenting
solutions
such
as
use
surfactants
or
compartmentalization
strategies
for
those
cases
where
incompatibilities
could
hamper
overall
process.
