European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 19, 2024
Abstract
A
novel
and
highly
efficient
method
for
the
synthesis
of
2,4,6‐triaryl‐1,3,5‐triazines
2,4,6‐trisubstituted
pyrimidines
from
amidines
alcohols
has
been
established.
Using
an
Earth‐abundant
air‐stable
chromium
salt
catalyst
a
phosphine‐free
ligand,
developed
Cr‐catalyzed
acceptorless
dehydrogenative
coupling
provides
1,3,5‐triazines
with
high
yields
good
functional
group
tolerance.
Moreover,
synthetic
value
this
operationally
simple
protocol
was
demonstrated
by
gram‐scale
experiment
linker
to
construct
various
supramolecular
complexes.
RSC Advances,
Год журнала:
2022,
Номер
12(8), С. 4510 - 4520
Опубликована: Янв. 1, 2022
A
series
of
nickel(
ii
)
complexes
supported
by
the
new
tridentate
P3
and
tetradentate
P4
ligands
act
efficiently
as
catalysts
for
N
-alkylation
primary
amines
with
alcohols.
European Journal of Inorganic Chemistry,
Год журнала:
2022,
Номер
2022(18)
Опубликована: Апрель 8, 2022
Abstract
The
catalytic
activity
of
Ru(II)‐arene
complexes
containing
ferrocene
thiosemicarbazone
(Fc‐TSC)
ligands
was
investigated
towards
the
selective
synthesis
1,2‐disubstituted
benzimidazoles
via
acceptorless
dehydrogenative
coupling
diamines
with
primary
alcohols.
A
series
Ru(II)‐
p
‐cymene
(
1
–
4
)
Fc‐TSC
(L
–L
were
synthesized
and
characterized.
From
single
crystal
X‐ray
crystallographic
studies,
molecular
structures
L
3
confirmed.
influence
electronic
effect
on
their
studied.
good
performer
i.
e
.
compared
that
its
benzene
counterpart
5
).
catalysis
extended
to
aromatic,
aliphatic
heterocyclic
substituted
alcohols,
phenylenediamines
electron‐donating
or
‐withdrawing
substituents.
Overall,
accomplished
moderate
yields,
hydrogen
water
as
only
by‐products.
Catalysts,
Год журнала:
2021,
Номер
11(9), С. 1108 - 1108
Опубликована: Сен. 15, 2021
N-heterocycles,
both
saturated
and
unsaturated,
are
ubiquitous
biologically
active
molecules
that
extremely
appealing
scaffolds
in
drug
discovery
programs.
Although
classical
synthetic
methods
have
been
developed
to
access
many
relevant
N-heterocyclic
scaffolds,
representing
well-established
reliable
routes,
some
do
not
meet
the
needs
of
sustainability.
In
this
context,
several
advances
made
towards
sustainable
synthesis
N-heterocycles.
This
review
focuses
on
most
recent
examples
from
last
five
years
catalytic
heterocyclic
compounds
medicinal
relevance.
Thus,
isoindoloquinazolines,
quinazolines
azaindoles,
among
others,
covered.
The
selected
include
use
homogeneous
heterogeneous
catalysts
alternative
such
as,
for
example,
metal-catalyzed
acceptorless
coupling
one-pot
reactions.
green
aspects
individual
approaches
highlighted,
scope
each
methodology
is
described.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 19, 2024
Abstract
A
novel
and
highly
efficient
method
for
the
synthesis
of
2,4,6‐triaryl‐1,3,5‐triazines
2,4,6‐trisubstituted
pyrimidines
from
amidines
alcohols
has
been
established.
Using
an
Earth‐abundant
air‐stable
chromium
salt
catalyst
a
phosphine‐free
ligand,
developed
Cr‐catalyzed
acceptorless
dehydrogenative
coupling
provides
1,3,5‐triazines
with
high
yields
good
functional
group
tolerance.
Moreover,
synthetic
value
this
operationally
simple
protocol
was
demonstrated
by
gram‐scale
experiment
linker
to
construct
various
supramolecular
complexes.
