Recent progress in ferroptosis: inducers and inhibitors

Cell Death Discovery, Год журнала: 2022, Номер 8(1)

Опубликована: Дек. 29, 2022

Ferroptosis is a new iron-dependent form of programmed cell death characterized by iron accumulation and lipid peroxidation. In recent years, ferroptosis has garnered enormous interest in disease treatment research communities pursuit to reveal the mechanism key targets because closely related pathophysiological processes many diseases. Recent studies have shown some targets, such as glutathione peroxidase 4 (GPX4) System Xc-, several inducers inhibitors been developed regulate these targets. With emergence on made developments. The selection use are very important for work. This paper briefly introduces regulatory metabolic pathway, lists categorizes commonly used recently inhibitors, discusses their medical application. ends with potential future direction ferroptosis.

Язык: Английский

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Ferroptosis Detection: From Approaches to Applications

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(35)

Опубликована: Фев. 25, 2023

Abstract Understanding the intricate molecular machinery that governs ferroptosis and leveraging this accumulating knowledge could facilitate disease prevention, diagnosis, treatment, prognosis. Emerging approaches for in situ detection of major regulators biological events across cellular, tissue, living subjects provide a multiscale perspective studying ferroptosis. Furthermore, advanced applications integrate latest technologies hold tremendous promise research. In review, we first briefly summarize mechanisms key underlying Ferroptosis are then presented to delineate their design, action, applications. Special interest is placed on multifunctional platforms. Finally, discuss prospects challenges applications, with aim providing roadmap theranostic development broad range ferroptosis‐related diseases.

Язык: Английский

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Construction of Fe-doped ZIF-8/DOX nanocomposites for ferroptosis strategy in the treatment of breast cancer

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(27), С. 6335 - 6345

Опубликована: Янв. 1, 2023

The DOX@7FZ was able to enhance the ROS level in cancer cells via a synergistic effect between apoptosis/ferroptosis synergism.

Язык: Английский

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Induction and application of ferroptosis in cancer therapy

Cancer Cell International, Год журнала: 2022, Номер 22(1)

Опубликована: Янв. 7, 2022

At present, more than one cell death pathways have been found, of which is ferroptosis. Ferroptosis was discovered in 2012 and described as an iron-dependent lipid peroxidation-driven regulated pathway. In the past few years, ferroptosis has shown to induce tumor death, providing new ideas for treatment. this article, we summarize latest advances ferroptosis-induced therapy at intersection biology, molecular redox materials chemistry. First, state characteristics cells, then introduce key mechanism ferroptosis, describes relationship between oxidative stress signaling pathways. Finally, focused on several types inducers by scholars, application systemic chemotherapy, radiotherapy, immunotherapy nanomedicine, hope that can exert its potential treatment tumors.

Язык: Английский

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Coronas of micro/nano plastics: a key determinant in their risk assessments

Particle and Fibre Toxicology, Год журнала: 2022, Номер 19(1)

Опубликована: Авг. 6, 2022

Abstract As an emerging pollutant in the life cycle of plastic products, micro/nanoplastics (M/NPs) are increasingly being released into natural environment. Substantial concerns have been raised regarding environmental and health impacts M/NPs. Although diverse M/NPs detected environment, most them display two similar features, i.e.,high surface area strong binding affinity, which enable extensive interactions between surrounding substances. This results formation coronas, including eco-coronas bio-coronas, on different media. In real exposure scenarios, corona is inevitable often displays variable complex structures. The coronas found to impact transportation, uptake, distribution, biotransformation toxicity particulates. Different from conventional toxins, packages rather than bare particles more dangerous. We, therefore, recommend seriously consideration role safety assessments. review summarizes recent progress eco–coronas bio-coronas M/NPs, further discusses analytical methods interpret structures, highlights provides future perspectives.

Язык: Английский

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The role of ferroptosis mediated by NRF2/ERK-regulated ferritinophagy in CdTe QDs-induced inflammation in macrophage

Journal of Hazardous Materials, Год журнала: 2022, Номер 436, С. 129043 - 129043

Опубликована: Май 4, 2022

Язык: Английский

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Ferroptosis of immune cells in the tumor microenvironment

Trends in Pharmacological Sciences, Год журнала: 2023, Номер 44(8), С. 542 - 552

Опубликована: Июнь 27, 2023

Язык: Английский

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In vivo assembly enhanced binding effect augments tumor specific ferroptosis therapy

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Янв. 11, 2024

Abstract Emerging evidence indicates that the activation of ferroptosis by glutathione peroxidase 4 (GPX4) inhibitors may be a prominent therapeutic strategy for tumor suppression. However, wide application GPX4 in therapy is hampered due to poor delivery efficacy and nonspecific ferroptosis. Taking advantage vivo self-assembly, we develop peptide-ferriporphyrin conjugate with microenvironment specific improve penetration, endocytosis inhibition, ultimately enhancing its anticancer activity via Briefly, inhibitory peptide conjugated an assembled linker decorated pH-sensitive moiety ferriporphyrin produce ( Gi-F-CAA ). Under acidic tumor, self-assembles into large nanoparticles (Gi-F) enhanced hydrophobic interaction after hydrolysis CAA, improving efficiency. Importantly, Gi-F exhibits substantial inhibition assembly binding AEB ) effect, augmenting oxidative stress ferriporphyrin-based Fenton reaction, enabling antitumor properties multiple models. Our findings suggest this design effect can induction ferroptosis, providing alternative overcoming chemoresistance.

Язык: Английский

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Delivering metal ions by nanomaterials: Turning metal ions into drug-like cancer theranostic agents

Coordination Chemistry Reviews, Год журнала: 2023, Номер 494, С. 215332 - 215332

Опубликована: Июль 17, 2023

Язык: Английский

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Alkaline “Nanoswords” Coordinate Ferroptosis-like Bacterial Death for Antibiosis and Osseointegration

ACS Nano, Год журнала: 2023, Номер 17(3), С. 2711 - 2724

Опубликована: Янв. 20, 2023

Ferroptosis is an iron-dependent cell death and associated with cancer therapy. Can it play a role in resistance of postoperative infection implants, especially extracellular supplement Fe ions non-cytotoxic dose? To answer this, "nanoswords" Fe-doped titanite are fabricated on Ti implant surface to resist bacterial invasion by synergistic action ferroptosis-like bacteria killing, proton disturbance, physical puncture. The related antibiosis mechanism explored atomic force microscopy genome sequencing. nanoswords induce increased local pH value, which not only weakens the motive force, reducing adenosine triphosphate synthesis Staphylococcus aureus, but also decreases membrane modulus, making distort even puncture easily. Simultaneously, more taken due permeability, resulting bacteria, this demonstrated intracellular iron enrichment, lipid peroxidation, glutathione depletion. Interestingly, microenvironment constructed these improves osteoblast behavior vitro bone regeneration vivo. Overall, can without cytotoxicity have great promise applications clinical implants for outstanding biointegration performance.

Язык: Английский

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