RSC Advances, Год журнала: 2022, Номер 12(30), С. 19640 - 19666
Опубликована: Янв. 1, 2022
This review article demonstrates the various synthetic pathways of five-membered nitrogen-containing heterocycles such as pyrroles, pyrazoles, imidazoles, triazoles and tetrazoles catalysed by metallic nanocatalysts.
Язык: Английский
Molecules, Год журнала: 2021, Номер 26(14), С. 4213 - 4213
Опубликована: Июль 11, 2021
Nitrogen-containing heterocyclic rings are common structural components of marketed drugs. Among these heterocycles, imidazole/fused imidazole present in a wide range bioactive compounds. The unique properties such structures, including high polarity and the ability to participate hydrogen bonding coordination chemistry, allow them interact with biomolecules, imidazole-/fused imidazole-containing compounds reported have broad spectrum biological activities. This review summarizes recent reports derivatives as anticancer agents appearing peer-reviewed literature from 2018 through 2020. Such molecules been shown modulate various targets, microtubules, tyrosine serine-threonine kinases, histone deacetylases, p53-Murine Double Minute 2 (MDM2) protein, poly (ADP-ribose) polymerase (PARP), G-quadraplexes, other targets. Imidazole-containing that display activity by unknown/undefined mechanisms also described, well key features structure-activity relationships. is intended provide an overview advances imidazole-based drug discovery development, inspire design synthesis new molecules.
Язык: Английский
Процитировано
132
Journal of Molecular Structure, Год журнала: 2022, Номер 1274, С. 134487 - 134487
Опубликована: Ноя. 6, 2022
Язык: Английский
Процитировано
49
European Journal of Medicinal Chemistry, Год журнала: 2022, Номер 240, С. 114576 - 114576
Опубликована: Июль 3, 2022
Язык: Английский
Процитировано
46
Journal of Genetic Engineering and Biotechnology, Год журнала: 2020, Номер 18(1), С. 69 - 69
Опубликована: Ноя. 3, 2020
The COVID-19 pandemic caused by SARS-CoV-2 has shown an exponential trend of infected people across the planet. Crediting its virulent nature, it becomes imperative to identify potential therapeutic agents against deadly virus. 3-chymotrypsin-like protease (3CLpro) is a cysteine which causes proteolysis replicase polyproteins generate functional proteins, crucial step for viral replication and infection. Computational methods have been applied in recent studies promising inhibitors 3CLpro inhibit activity. This review provides overview drug/lead candidates identified so far through various silico approaches such as structure-based virtual screening (SBVS), ligand-based (LBVS) drug-repurposing/drug-reprofiling/drug-retasking. Further, drugs classified according their chemical structures or biological activity into flavonoids, peptides, terpenes, quinolines, nucleoside nucleotide analogues, inhibitors, phenalene antibiotic derivatives. These are then individually discussed based on structural parameters namely estimated free energy binding (ΔG), key interacting residues, types intermolecular interactions stability 3CLpro-ligand complexes obtained from results molecular dynamics (MD) simulations. comprehensive information several computational thus better understanding interaction patterns dynamic states ligand-bound structures.
Язык: Английский
Процитировано
56
Chinese Journal of Chemistry, Год журнала: 2021, Номер 39(8), С. 2251 - 2263
Опубликована: Май 1, 2021
Main observation and conclusion The limit ability of traditional antibiotics to treat drug resistant bacteria calls for new therapeutic alternatives. A class unique sulfanilamide aminophosphonates as potential agents against microbes was synthesized by one‐pot three‐component reaction. Noticeably, fluorobenzyl derivative 5d (MIC = 2 μg/mL) active E. coli infection exerted no obvious toxicity towards human mammalian cells. Compound also displayed good anti‐biofilm activity low possibility induce resistance. Mechanism investigation elucidated that molecule could disrupt membrane through generation reactive oxygen (ROS) then intercalate into deoxyribonucleic acid (DNA) form a steady 5d‐DNA complex, which led bacterial death. These results indicated would shed light on developing novel antibacterial agents.
Язык: Английский
Процитировано
56
Molecules, Год журнала: 2023, Номер 28(6), С. 2751 - 2751
Опубликована: Март 18, 2023
Several nitrogen heterocyclic analogues have been applied to clinical practice, and about 75% of drugs approved by the FDA contain at least a moiety. Thus, heterocycles are beneficial scaffolds that occupy central position in development new drugs. The fact certain compounds significantly activate NRF2/ARE signaling pathway upregulate expression NRF2-dependent genes, especially HO-1 NQO1, underscores need study roles pharmacological effects N-based moieties NRF2 activation. Furthermore, exhibit significant antioxidant anti-inflammatory activities. NRF2-activating molecules tremendous research interest recent times due their therapeutic neuroinflammation oxidative stress-mediated diseases. A comprehensive review NRF2-inducing activities derivatives will broaden prospects wide range present review, as first its kind, provides an overview activation underpinning actions several diseases, properties structural–activity relationship also discussed with aim making discoveries stimulate innovative this area.
Язык: Английский
Процитировано
23
ChemistrySelect, Год журнала: 2023, Номер 8(47)
Опубликована: Дек. 13, 2023
Abstract Nitrogen‐containing heterocycles such as imidazoles, thiazoles, and oxazoles play a significant role in the fields of biological pharmaceutical chemistry. These compounds were widely used for agrochemical, pesticide, medicinal, industrial applications. Due to wide spectrum structural diversity well activity N ‐heterocycles, plethora reports on their synthesis have appeared last few decades. However, developments various bond‐forming strategies C−C, C−N, C−O, C−S, N−N, C−H activation, been powerful synthetic tool derive copious ‐heterocycles. The most prominent fascinating imidazole, thiazole, oxazoles, benzimidazole moieties by C−C C−N coupling reactions, multi‐component cycloaddition etc. are discussed this study. studies demonstrated enormous potential methods accelerating modern chemical establishing molecular beauty through bonding. aspects methodologies, like optimized conditions, substrate scope, mechanistic investigations, detail.
Язык: Английский
Процитировано
19
ACS Catalysis, Год журнала: 2020, Номер 11(1), С. 82 - 87
Опубликована: Дек. 14, 2020
Thiobenzoic acid (TBA) can serve as a single-electron reducing agent under photoirradiation from blue light-emitting diode, in the presence of appropriate electron acceptors, and resulting sulfur-centered radical species undergoes hydrogen atom abstraction. This dual-role catalysis by TBA enables regioselectivie Cα–H arylation benzylamines, benzyl alcohols, ethers, well dihydroimidazoles, with cyano(hetero)arenes good yield, without need for transition-metal photocatalyst and/or synthetically elaborated organic dyes.
Язык: Английский
Процитировано
50
Dyes and Pigments, Год журнала: 2022, Номер 205, С. 110539 - 110539
Опубликована: Июль 16, 2022
Язык: Английский
Процитировано
26
Tetrahedron, Год журнала: 2024, Номер 167, С. 134246 - 134246
Опубликована: Сен. 6, 2024
Язык: Английский
Процитировано
6