Green Synthesis and Catalysis,
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 1, 2023
Ethers
are
among
the
most
important
chemicals
in
organic
synthesis,
pharmaceutical
industry,
agrochemical
production,
and
material
science.
C-O
bond
formation
via
substitution
is
one
of
widely
used
strategies
for
ether
formation.
However,
known
methods
usually
employ
transition-metal
bases
to
facilitate
process.
In
this
work,
we
describe
base-
transition-metal-free
alcohol
phenol-participated
substitution.
The
protocol
allows
access
a
large
number
ethers
with
enyne
functional
moieties,
features
mild
reaction
conditions,
high
efficiency,
good
regio-
stereoselectivities.
could
be
readily
scaled
up,
products
range
further
transformations.
Chemical Communications,
Год журнала:
2022,
Номер
58(96), С. 13298 - 13316
Опубликована: Янв. 1, 2022
MIDA
boronates
have
been
widely
applied
as
building
blocks
in
the
synthesis
of
natural
products
and
pharmaceuticals
precursors.
This
review
highlights
recent
advances
provides
a
comprehensive
summary
their
reactivity.
Chemistry - A European Journal,
Год журнала:
2022,
Номер
28(44)
Опубликована: Апрель 19, 2022
Abstract
Heteroaryl
boronic
acids
and
esters
are
extremely
important
valuable
intermediates
because
of
their
wide
application
in
the
synthesis
marketed
drugs
bioactive
compounds.
Over
last
couple
decades,
construction
highly
heteroaryl
carbon‐boron
bonds
has
created
huge
attention.
The
transition‐metal‐free
protocols
more
green,
less
sensitive
to
air
moisture,
also
economically
advantageous
over
transition‐metal‐based
protocols.
C−H
borylation
heteroarenes
C−X
(X=halogen)
halides
represents
an
excellent
approach
for
synthesis.
Also,
various
cyclization
alkyne
activation
have
been
recently
established
goal
this
review
article
is
summarize
existing
literature
current
state
art
acid
esters.
Chemistry - A European Journal,
Год журнала:
2021,
Номер
28(3)
Опубликована: Окт. 29, 2021
A
practical
and
direct
method
was
developed
for
the
production
of
versatile
alkyl
boronate
esters
via
transition
metal-free
borylation
primary
secondary
sulfones.
The
key
to
success
strategy
is
use
bis(neopentyl
glycolato)
diboron
(B
Chemistry - A European Journal,
Год журнала:
2022,
Номер
29(4)
Опубликована: Окт. 13, 2022
In
this
work,
the
molecular
aluminium
dihydride
complex
bearing
an
N,
N'-chelated
conjugated
bis-guanidinate
(CBG)
ligand
is
used
as
a
catalyst
for
reducing
wide
range
of
aryl
and
alkyl
esters
with
good
tolerance
alkene
(C=C),
alkyne
(C≡C),
halides
(Cl,
Br,
I
F),
nitrile
(C≡N),
nitro
(NO2
)
functionalities.
Further,
we
investigated
catalytic
application
in
C-O
bond
cleavage
epoxides
into
corresponding
branched
Markovnikov
ring-opening
products.
addition,
chemoselective
intermolecular
reduction
over
other
reducible
functional
groups,
such
amides
alkenes,
has
been
established.
Intermediates
are
isolated
characterized
by
NMR
HRMS
studies,
which
confirm
probable
cycles
hydroboration
epoxides.
Green Synthesis and Catalysis,
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 1, 2023
Ethers
are
among
the
most
important
chemicals
in
organic
synthesis,
pharmaceutical
industry,
agrochemical
production,
and
material
science.
C-O
bond
formation
via
substitution
is
one
of
widely
used
strategies
for
ether
formation.
However,
known
methods
usually
employ
transition-metal
bases
to
facilitate
process.
In
this
work,
we
describe
base-
transition-metal-free
alcohol
phenol-participated
substitution.
The
protocol
allows
access
a
large
number
ethers
with
enyne
functional
moieties,
features
mild
reaction
conditions,
high
efficiency,
good
regio-
stereoselectivities.
could
be
readily
scaled
up,
products
range
further
transformations.
