Sustainability of green solvents – review and perspective

Green Chemistry, Год журнала: 2021, Номер 24(2), С. 410 - 437

Опубликована: Дек. 3, 2021

Life cycle of an ideal green solvent from cradle to grave for sustainability studies solvents.

Язык: Английский

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The E factor at 30: a passion for pollution prevention

Green Chemistry, Год журнала: 2023, Номер 25(5), С. 1704 - 1728

Опубликована: Янв. 1, 2023

Publication of the E Factor drew attention to problem waste in chemicals manufacture. Thirty yeas later it is abundantly clear that underlying cause global environmental problems, from climate change plastic pollution.

Язык: Английский

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Expanding the Synthetic Toolbox through Metal–Enzyme Cascade Reactions

Chemical Reviews, Год журнала: 2023, Номер 123(9), С. 5297 - 5346

Опубликована: Янв. 10, 2023

The combination of metal-, photo-, enzyme-, and/or organocatalysis provides multiple synthetic solutions, especially when the creation chiral centers is involved. Historically, enzymes and transition metal species have been exploited simultaneously through dynamic kinetic resolutions racemates. However, more recently, linear cascades appeared as elegant solutions for preparation valuable organic molecules combining bioprocesses metal-catalyzed transformations. Many advantages are derived from this symbiosis, although there still bottlenecks to be addressed including successful coexistence both catalyst types, need compatible reaction media mild conditions, or minimization cross-reactivities. Therefore, here also provided by means coimmobilization, compartmentalization strategies, flow chemistry, etc. A comprehensive review presented focusing on period 2015 early 2022, which has divided into two main sections that comprise first use metals independent catalysts but working in an orchestral sequential manner, later their application bionanohybrid materials coimmobilization adequate supports. Each part classified different subheadings, based catalyzed catalyst, while development nonasymmetric stereoselective processes was considered section.

Язык: Английский

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Biocatalysis for the Synthesis of Active Pharmaceutical Ingredients in Deep Eutectic Solvents: State-of-the-Art and Prospects

Catalysts, Год журнала: 2024, Номер 14(1), С. 84 - 84

Опубликована: Янв. 19, 2024

Biocatalysis holds immense potential for pharmaceutical development as it enables synthetic routes to various chiral building blocks with unparalleled selectivity. Therein, solvent and water use account a large contribution the environmental impact of reactions. In spirit Green Chemistry, transition from traditional highly diluted aqueous systems intensified non-aqueous media overcome limitations (e.g., shortages, recalcitrant wastewater treatments, low substrate loadings) has been observed. Benefiting spectacular advances in enzyme stabilization techniques, plethora biotransformations non-conventional have established. Deep eutectic solvents (DESs) emerge sort (potentially) greener medium increasing biocatalysis. This review discusses state-of-the-art DESs focus on biocatalytic pathways synthesis active ingredients (APIs). Representative examples different classes are discussed, together critical vision discussing prospects using

Язык: Английский

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Transforming nature into the next generation of bio-based flexible devices: New avenues using deep eutectic systems

Matter, Год журнала: 2021, Номер 4(7), С. 2141 - 2162

Опубликована: Июль 1, 2021

Язык: Английский

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Bulk and interfacial nanostructure and properties in deep eutectic solvents: Current perspectives and future directions

Journal of Colloid and Interface Science, Год журнала: 2021, Номер 608, С. 2430 - 2454

Опубликована: Окт. 29, 2021

Язык: Английский

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Natural Deep Eutectic Solvents Based on Choline Chloride and Phenolic Compounds as Efficient Bioadhesives and Corrosion Protectors

ACS Sustainable Chemistry & Engineering, Год журнала: 2022, Номер 10(25), С. 8135 - 8142

Опубликована: Июнь 13, 2022

Natural deep eutectics solvents (NADES), owing to their high solvation capacity and nontoxicity, are actively being sought for many technological applications. Herein, we report a series of novel NADES based on choline chloride plant-derived polyphenols. Most the obtained phenolic have wide liquid range thermal stability above 150 °C. Among them, small-sized polyphenols, like pyrogallol, vanillyl alcohol, or gentisic acid, lead low-viscosity liquids with ionic conductivities in order 10-3 S cm-1 at room temperature. Interestingly, polyphenols possess valuable properties as therapeutic agents, antioxidants, adhesives, redox-active compounds, among others. Thus, evaluated potential these two applications: bioadhesives corrosion protection. The mixture chloride-vanillyl alcohol (2:3 mol ratio) gelatin resulted highly adhesive viscoelastic (adhesive stress ≈ 135 kPa), affording shear thinning behavior. Furthermore, chloride-tannic acid (20:1) showed an extraordinary ability coordinate iron ions, reaching excellent inhibitive efficiencies mild steel

Язык: Английский

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Deep Eutectic Solvents in Solar Energy Technologies

Molecules, Год журнала: 2022, Номер 27(3), С. 709 - 709

Опубликована: Янв. 21, 2022

Deep Eutectic Solvents (DESs) have been widely used in many fields to exploit their ecofriendly characteristics, from green synthetic procedures environmentally benign industrial methods. In contrast, application emerging solar technologies, where the abundant and clean energy is properly respond most important societal needs, still relatively scarce. This represents a strong limitation since devices make use of polluting or toxic components, thus seriously hampering eco-friendly nature. Herein, we review literature, mainly published last few years, on DESs representative plants generation photovoltaics, featuring not only passive role as solvents, but also active behavior arising peculiar chemical collection highlights increasing valuable played by fulfillment chemistry requirements for performance enhancement, particular terms long-term temporal stability.

Язык: Английский

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Critical Assessment of the Sustainability of Deep Eutectic Solvents: A Case Study on Six Choline Chloride-Based Mixtures

ACS Omega, Год журнала: 2022, Номер 7(51), С. 47449 - 47461

Опубликована: Дек. 13, 2022

An outline of the advantages, in terms sustainability, Deep Eutectic Solvents (DESs) is provided, by analyzing some most popular DESs, obtained combination choline chloride, as a hydrogen bond acceptor, and six donors. The analysis articulated into four main issues related to which are recurrently mentioned literature, but often taken for granted without any further critical elaboration, prominent green features DESs: their low toxicity, good biodegradability, renewable sourcing, cost. This contribution intended provide more tangible, evidence-based evaluation actual credentials considered reinforce or question supposed also mutual comparison with one another.

Язык: Английский

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Deep Eutectic Solvents for Improving the Solubilization and Delivery of Dapsone

Pharmaceutics, Год журнала: 2022, Номер 14(2), С. 333 - 333

Опубликована: Янв. 30, 2022

Owing to a growing awareness toward environmental impact, the use of safer and eco-friendly solvents like deep eutectic (DESs), has recently undergone important growth in pharmaceutical field, with regard their application as non-aqueous liquid administration vehicles, since they do not carry same risks toxicity handling traditional organic solvents. Major attention been given development advantageous transdermal drug delivery systems, because ease better acceptability. Here, we report two different DESs, based on choline chloride, used hydrogen bond acceptor (HBA), ascorbic acid or propylene glycol, donors (HBDs), able enhance solubility topical dapsone, representing class IV drug. The interactions between DESs' components were studied by performing DSC, FT-IR, NMR analysis systems pure drug, confirming establishment H-bonds components. Diffusion permeability studies, carried out Franz cell, showed an increase permeability, highlighting great potential DESs dissolution permeation enhancers novel more effective administration.

Язык: Английский

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