Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
38(4)
Опубликована: Фев. 7, 2024
A
highly
efficient,
green,
and
multicomponent
reaction
method
has
been
developed
for
the
diversity‐oriented
synthesis
of
32
spirooxindole
derivatives
via
formation
cascade
C–N,
C–O,
C–S
bonds.
The
involved
starch‐capped
zinc
oxide
nanocomposite
as
an
effective
heterogeneous
catalyst
with
synergistic
application
ultrasound
on‐water
synthesis.
By
employing
this
approach,
all
desired
products
were
successfully
obtained
high
yields
comparatively
short
times.
Furthermore,
employed
in
process
exhibited
excellent
recyclability,
allowing
its
recovery
reuse
up
to
eight
consecutive
runs
without
any
loss
catalytic
activity.
greenness
protocol
was
evaluated
by
various
green
metrics
such
E‐factor
eco‐score,
result
showed
acceptability
present
organic
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(5), С. 2975 - 2984
Опубликована: Янв. 25, 2023
Multicomponent
reactions
(MCRs)
can
be
used
to
introduce
different
functionalities
into
highly
stable
covalent
organic
frameworks
(COFs).
In
this
work,
the
irreversible
three-component
Doebner
reaction
is
utilized
synthesize
four
chemically
quinoline-4-carboxylic
acid
DMCR-COFs
(DMCR-1-3
and
DMCR-1NH)
equipped
with
an
acid-base
bifunctionality.
These
show
superior
photocatalytic
H2O2
evolution
(one
of
most
important
industrial
oxidants)
compared
imine
COF
analogue
(Imine-1).
This
achieved
sacrificial
oxidants
but
also
in
pure
water
under
oxygen
or
air
atmosphere.
Furthermore,
high
photostability,
durability,
recyclability.
MCR-COFs
thus
provide
a
viable
materials'
platform
for
solar
chemical
energy
conversion.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(19), С. 6680 - 6714
Опубликована: Янв. 1, 2023
The
quantitative
assessment
of
the
greenness
mechanochemical
processes
for
green
metrics
were
calculated
is
herein
reported.
A
general
introduction
to
topic,
variables
influencing
reaction
outcome
and,
an
outlook
are
also
provided.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(7), С. 6581 - 6581
Опубликована: Апрель 1, 2023
Multicomponent
reactions
(MCRs)
have
emerged
as
a
powerful
strategy
in
synthetic
organic
chemistry
due
to
their
widespread
applications
drug
discovery
and
development.
MCRs
are
flexible
transformations
which
three
or
more
substrates
react
form
structurally
complex
products
with
high
atomic
efficiency.
They
being
increasingly
appreciated
highly
exploratory
evolutionary
tool
by
the
medicinal
community,
opening
door
sustainable,
cost-effective
rapid
synthesis
of
biologically
active
molecules.
In
recent
years,
MCR-based
strategies
found
extensive
application
field
discovery,
several
anticancer
drugs
been
synthesized
through
MCRs.
this
review,
we
present
an
overview
representative
literature
examples
documenting
different
approaches
development
new
drugs.
Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(8)
Опубликована: Июль 20, 2023
Abstract
In
terms
of
pharmaceuticals
and
biological
applications,
synthesis
complex
organic
molecules
is
a
significant
fast‐developing
area.
this
context,
electrosynthesis
an
alternative
way
to
the
traditional
methods
for
chemo‐,
regio‐,
stereoselective
syntheses.
Electro‐organic
reactions
occur
at
room
temperature
normal
pressure,
through
transferring
electrons.
It
has
been
found
that
mild
approach
preparing
electrophilic
substrates,
bases,
nucleophiles
in
situ
,
from
highly
stable
low‐level
reagents;
which
can
be
further
applied
make
heterocycles
more
accessible.
While
several
promising
exist,
multi‐component
(MCRs)
have
drawn
much
attention
both
academia
industry
worldwide,
since
they
are
cost‐efficient
environmentally
friendly.
Combining
MCRs
produced
great
strategy
field
research.
This
review
focuses
on
recent
advances
electrochemical
heterocyclic
compounds
via
reactions,
reported
between
2015
March
2023.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(30)
Опубликована: Апрель 8, 2023
Abstract
The
use
of
ynamides
in
organic
synthesis
has
gained
significant
attention
due
to
their
ability
provide
access
complex
molecular
structures
through
transformations
such
as
1,2‐difunctionalization
and
annulation
reactions.
These
reactions
enable
the
formation
highly
functionalized
N‐bearing
olefins
unusual
heterocycles.
In
this
minireview,
we
present
a
systematic
overview
regioselective
difunctionalization
ynamides.
We
discuss
multi‐component
reactions,
radical‐triggered
functionalizations
across
carbon–carbon
multiple
bonds
bifunctional
reagents
ynamides,
highlighting
potential
expanding
substrate
scope.
Furthermore,
insights
into
mechanistic
breakthroughs
that
have
been
achieved
recent
years
development
these
Finally,
emphasize
promising
future
prospects
versatile
building
blocks
for
architectures.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(9), С. 2359 - 2384
Опубликована: Янв. 1, 2023
Multicomponent
reactions
(MCRs)
have
emerged
as
an
important
branch
in
organic
synthesis
for
the
creation
of
complex
molecular
structures.
This
review
is
focused
on
gold-catalyzed
MCRs
with
a
special
emphasis
recent
developments.
