The Journal of Organic Chemistry,
Год журнала:
2021,
Номер
86(23), С. 17504 - 17510
Опубликована: Ноя. 1, 2021
A
Cu(II)-promoted
synthesis
of
an
aza-fused
N-heterocycle
having
a
benz-imidazopyridine
scaffold
is
developed
via
addition–cyclization
reaction
followed
by
Ullmann-type
C–N
coupling
between
o-iodoanilines
and
γ-ketodinitriles.
This
protocol
features
broad
substrate
scope,
giving
products
in
32–84%
yields.
The
compounds
show
excellent
photoluminescence
properties
two
absorption
maxima
the
region
270–280
338–350
nm
emission
range
502–533
nm.
HOMO–LUMO
energy
gap
3.49–3.57
eV
was
determined
using
Gaussian
09
at
B3LYP/6-31G
(d,
p)
basis
set
level.
We
also
demonstrated
few
postsynthetic
modifications.
Next Materials,
Год журнала:
2024,
Номер
3, С. 100166 - 100166
Опубликована: Март 11, 2024
The
present
work
elicits
the
synthesis
of
2,2-dimethyl-2H-[1,3]dioxino[4,5-b]pyrrole-4(7H)-ones
derivatives
catalyzed
by
heterogeneous
Fe3O4
magnetic
nanoparticles
supported
N-acetyl-PABA@Cu(II),
which
address
limitations
traditional
organic
approaches
in
terms
sustainable
and
efficient,
resulting
improved
yields,
higher
selectivity
with
no
waste.
decorum
embraces
four-component
reactions
(4CRs)
amines,
aldehydes,
meldrum's
acid,
nitromethane
facilitated
Fe3O4-N-acetyl-PABA-Cu(II)
presence
ethanol
(CH3CH2OH)
as
an
ecologically
benign
solvent
under
ultrasonic
irradiation
at
room
temperature.
Outstanding
conversion
rates
were
attained
catalyst
through
great
catalytic
performance.
simple
work-up,
easy
recovery,
base
or
additional
activators
required.
Characterization
structures
synthesized
compounds
catalysts
was
corroborated
different
spectroanalytical
techniques
viz;
FTIR,
1H
&
13C
NMR,
Mass
elemental
analyses,
Energy-Dispersive
X-ray
Spectroscopy
(EDX),
Field-Emission
Scanning
Electron
Microscope
(FE-SEM),
Powder
Diffraction
(XRD),
Thermal
Gravimetric
Analysis
(TGA),
Differential
(DTA),
Particle
size
analysis
Zeta
potential.
Multicomponent
reactions
(MCRs)
provide
an
alternative
scheme
for
target
synthesis,
by
allowing
fast
and
efficient
synthetic
access
based
on
its
"one-pot"
character,
accessing
almost
unlimited
scaffold
diversity,
fostering
a
very
large
chemical
space
simple
building
blocks
available
in
numerous
derivatives,
addressing
challenging
issues
of
sustainability
("green
chemistry").
Hence,
MCR
can
be
potentially
useful
the
discovery
synthesis
biologically
active
"drug-like"
compounds.
Here,
we
highlight
examples
use
medicinal
chemistry,
from
drug
discovery,
drugs,
to
screening
libraries
biopharmaceutical
applications.
The
review
is
not
comprehensive
but
rather
personal
selection
authors
reader
overview
advantages
usefulness
MCR.
We
conclude
that
literature
analysis,
toto
,
supports
highly
underused
role
chemistry.
Luminescence,
Год журнала:
2021,
Номер
36(5), С. 1189 - 1197
Опубликована: Март 24, 2021
Abstract
In
this
present
investigation,
thiazolylcoumarin
derivatives
(
5a
–
5k
)
were
synthesized
from
thiosemicarbazide,
ethyl
acetoacetate,
and
naphthaldehyde
through
a
multistep
route.
The
formation
of
with
bioactive
scaffolds
was
confirmed
nuclear
magnetic
resonance
spectroscopy.
A
solvatochromic
study
carried
out
using
ultraviolet–visible
methods
for
dimethylformamide
(DMF),
acetate,
ethanol
solvents.
redox
behaviour
as‐synthesized
examined
in
dimethyl
sulphoxide
by
conducting
an
electrochemical
study.
Fluorescence
properties
studied
DMF,
ethanol,
acetate
to
visualize
the
solvent
effect
on
emitting
ability
derivatives.
The Journal of Organic Chemistry,
Год журнала:
2021,
Номер
86(23), С. 17504 - 17510
Опубликована: Ноя. 1, 2021
A
Cu(II)-promoted
synthesis
of
an
aza-fused
N-heterocycle
having
a
benz-imidazopyridine
scaffold
is
developed
via
addition–cyclization
reaction
followed
by
Ullmann-type
C–N
coupling
between
o-iodoanilines
and
γ-ketodinitriles.
This
protocol
features
broad
substrate
scope,
giving
products
in
32–84%
yields.
The
compounds
show
excellent
photoluminescence
properties
two
absorption
maxima
the
region
270–280
338–350
nm
emission
range
502–533
nm.
HOMO–LUMO
energy
gap
3.49–3.57
eV
was
determined
using
Gaussian
09
at
B3LYP/6-31G
(d,
p)
basis
set
level.
We
also
demonstrated
few
postsynthetic
modifications.
