Multifunctional chrysin-loaded gallic acid–glycerol monostearate conjugate-based injectable hydrogel for targeted inhibition of hypoxia-induced NLRP3 inflammasome in ulcerative colitis

Biomaterials Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Ulcerative colitis (UC) is a chronic inflammatory condition affecting the colon part of large intestine.

Язык: Английский

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Biomaterial-based strategies for immunomodulation in IBD: current and future scenarios

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(25), С. 5668 - 5692

Опубликована: Янв. 1, 2023

Overview of the different nanoformulations in treatment IBD.

Язык: Английский

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Cortisone-loaded stearoyl ascorbic acid based nanostructured lipid carriers alleviate inflammatory changes in DSS-induced colitis

Biomaterials Advances, Год журнала: 2023, Номер 148, С. 213383 - 213383

Опубликована: Март 15, 2023

Язык: Английский

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Multi-targeting inulin-based nanoparticles with cannabidiol for effective prevention of ulcerative colitis

Materials Today Bio, Год журнала: 2024, Номер 25, С. 100965 - 100965

Опубликована: Янв. 21, 2024

Язык: Английский

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Versatile Injectable Carboxymethyl Chitosan Hydrogel for Immediate Hemostasis, Robust Tissue Adhesion Barrier, and Antibacterial Applications

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер unknown

Опубликована: Ноя. 3, 2023

Iatrogenic ulcers resulting from endoscopic submucosal dissection surgery remain a significant clinical concern due to the risk of uncontrolled bleeding. Herein, we have developed an injectable shear-thinning hydrogel cross-linked through electrostatic interactions and hydrogen bonding. The underwent comprehensive characterization, focusing on rheological behavior, injectability, microstructure, film-forming capability, adhesion, swelling degradation kinetics, antibacterial efficacy, hemostatic performance, biocompatibility. incorporation poly(vinyl alcohol) notably enhanced internal structural stability injection pressure, while Laponite content influenced self-healing ability, modulus, viscosity. Additionally, exhibited pH sensitivity, appropriate degradation, rates displayed favorable adhesion properties. Notably, it demonstrated excellent resistance against Escherichia coli Staphylococcus aureus, highlighting its potential create optimal wound environment. In vivo studies further confirmed hydrogel's exceptional positioning as material for (ESD) surgery. Moreover, cell experiments hemolysis tests revealed high biocompatibility, supporting their facilitate healing iatrogenic post-ESD conclusion, our hydrogels hold great promise treatment materials ESD-induced given outstanding

Язык: Английский

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Caffeic Acid-Conjugated Budesonide-Loaded Nanomicelle Attenuates Inflammation in Experimental Colitis

Molecular Pharmaceutics, Год журнала: 2022, Номер 20(1), С. 172 - 182

Опубликована: Дек. 6, 2022

Ulcerative colitis is a multifactorial disease of the gastrointestinal tract which caused due to chronic inflammation in colon; it usually starts from lower end colon and may spread other portions large intestine, if left unmanaged. Budesonide (BUD) synthetically available second-generation corticosteroidal drug with potent local anti-inflammatory activity. The pharmacokinetic properties, such as extensive first-pass metabolism quite limited bioavailability, reduce its therapeutic efficacy. To overcome limitations, nanosized micelles were developed this study by conjugating stearic acid caffeic make an amphiphilic compound. aim present was evaluate pharmacological potential BUD-loaded mouse model dextran sulfate sodium-induced colitis. Micelles formulated solvent evaporation method, their physicochemical characterizations show spherical shape under microscopic techniques like atomic force microscopy, transmission electron scanning microscopy. vitro release experiment shows sustained behavior physiological media. These cytocompatible against hTERT-BJ cells up 500 μg/mL dose, evidenced more than 85% viable cells. successfully normalized activity index physical observation length. treatment alleviates severity analyzed histopathology efficiently, overcoming via downregulation various related cytokines (MPO, NO, TNF-α) inflammatory enzymes COX-2 iNOS. Results suggest that nano-sized effectively attenuate conditions

Язык: Английский

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Thiol-Functionalized Cellulose-Grafted Copper Oxide Nanoparticles for the Therapy of Experimental Colitis in Swiss Albino Mice

ACS Biomaterials Science & Engineering, Год журнала: 2022, Номер 8(5), С. 2088 - 2095

Опубликована: Апрель 22, 2022

Ulcerative colitis (UC) is a chronic inflammatory disease, which deleteriously affects the lower end of gastrointestinal tract, i.e., colon and rectum. UC colonic homeostasis disrupts intestinal barrier functions. Intestinal tissue damage activates immune system collectively worsens disease condition via production various cytokines. Ongoing therapeutics have marked limitations like rapid clearance, extensive first-pass metabolism, poor drug absorption, very low solubility, bioavailability, etc. Because these restrictions, management demands rational approach that selectively delivers at site action to overcome therapeutic limiting factors. Metallic nanoparticles (NPs) good efficacy against colitis, but their uses are limited due adverse effects on biological system. In this study, we used biocompatible thiol-functionalized cellulose-grafted copper oxide (C-CuI/IIO NPs) treat UC. The metal NPs alleviated as evidenced by length observed physical parameters. Analysis histopathology demonstrated recovery architecture damaged dextran sulfate sodium-induced colitis. Treatment with C-CuI/IIO reduced disintegration goblet cells retainment sulfomucin. Significant downregulation markers MPO activity, well levels nitrite TNF-α, was found following NP treatment. observations from study suggested intrarectal treatment cellulose-based successfully combated condition.

Язык: Английский

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Co-Delivery of Glycyrrhizin and Paclitaxel via Gelatin-Based Core–Shell Nanoparticles Ameliorates 1,2-Dimethylhydrazine-Induced Precancerous Lesions in Colon

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Янв. 26, 2025

Colorectal cancer is a lethal malignancy that begins from acquired/inherent premalignant lesions. Thus, targeting these lesions at an early stage of the disease could impede oncogenesis and maximize efficacy. The present work underscores combinatorial therapy paclitaxel (PTX) glycyrrhizin (GL) delivered via gelatin-derived core-shell nanoparticles [AC-PCL(GL + PTX)-GNPs] for effective management precancerous desolvation method was adopted to prepare GL-loaded gelatin (GL-GNPs), which were coated with PTX AC-PCL. prepared NPs exhibited optimal physical attributes had spherical morphology, as analyzed by transmission electron microscopy field-emission scanning microscopy. In vitro release studies revealed sustained ∼96 h. Cell culture in HTC 116, HT-29 cells showed synergistic action CI < 0.9 DRI > 1. Moreover, AC-PCL(GL PTX)-GNPs amplified intracellular uptake thus significantly reduced IC50. Pharmacokinetic substantiated pharmacokinetic parameters (AUC0-∞, Cmax, etc.). vivo 1,2-dimethyl hydrazine-induced model decrease number lesions, mucin depletion, subside infiltrations. An immunohistochemical study elevated expression caspase-9 suppressed VEGF Ki-67. Toxicity insignificant changes systemic biomarkers along no alterations organ morphology hemocompatibility. essence, render competent safer tactic regulate early-stage

Язык: Английский

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Inflammatory Bowel Disease: Exploring Pathogenesis, Epidemiology, Conventional Therapies, and Advanced Nanoparticle Based Drug Delivery Systems

BioNanoScience, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 28, 2025

Язык: Английский

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Nano-Based Targeted Drug Delivery in Ulcerative Colitis

Опубликована: Янв. 1, 2025

Язык: Английский

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