Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 88, С. 104903 - 104903
Опубликована: Сен. 1, 2023
Язык: Английский
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 88, С. 104903 - 104903
Опубликована: Сен. 1, 2023
Язык: Английский
European Polymer Journal, Год журнала: 2024, Номер 218, С. 113338 - 113338
Опубликована: Июль 26, 2024
Язык: Английский
Процитировано
7Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(25), С. 5668 - 5692
Опубликована: Янв. 1, 2023
Overview of the different nanoformulations in treatment IBD.
Язык: Английский
Процитировано
16Biomaterials Advances, Год журнала: 2023, Номер 148, С. 213383 - 213383
Опубликована: Март 15, 2023
Язык: Английский
Процитировано
15Materials Today Bio, Год журнала: 2024, Номер 25, С. 100965 - 100965
Опубликована: Янв. 21, 2024
Язык: Английский
Процитировано
6Molecular Pharmaceutics, Год журнала: 2022, Номер 20(1), С. 172 - 182
Опубликована: Дек. 6, 2022
Ulcerative colitis is a multifactorial disease of the gastrointestinal tract which caused due to chronic inflammation in colon; it usually starts from lower end colon and may spread other portions large intestine, if left unmanaged. Budesonide (BUD) synthetically available second-generation corticosteroidal drug with potent local anti-inflammatory activity. The pharmacokinetic properties, such as extensive first-pass metabolism quite limited bioavailability, reduce its therapeutic efficacy. To overcome limitations, nanosized micelles were developed this study by conjugating stearic acid caffeic make an amphiphilic compound. aim present was evaluate pharmacological potential BUD-loaded mouse model dextran sulfate sodium-induced colitis. Micelles formulated solvent evaporation method, their physicochemical characterizations show spherical shape under microscopic techniques like atomic force microscopy, transmission electron scanning microscopy. vitro release experiment shows sustained behavior physiological media. These cytocompatible against hTERT-BJ cells up 500 μg/mL dose, evidenced more than 85% viable cells. successfully normalized activity index physical observation length. treatment alleviates severity analyzed histopathology efficiently, overcoming via downregulation various related cytokines (MPO, NO, TNF-α) inflammatory enzymes COX-2 iNOS. Results suggest that nano-sized effectively attenuate conditions
Язык: Английский
Процитировано
18ACS Applied Materials & Interfaces, Год журнала: 2023, Номер unknown
Опубликована: Ноя. 3, 2023
Iatrogenic ulcers resulting from endoscopic submucosal dissection surgery remain a significant clinical concern due to the risk of uncontrolled bleeding. Herein, we have developed an injectable shear-thinning hydrogel cross-linked through electrostatic interactions and hydrogen bonding. The underwent comprehensive characterization, focusing on rheological behavior, injectability, microstructure, film-forming capability, adhesion, swelling degradation kinetics, antibacterial efficacy, hemostatic performance, biocompatibility. incorporation poly(vinyl alcohol) notably enhanced internal structural stability injection pressure, while Laponite content influenced self-healing ability, modulus, viscosity. Additionally, exhibited pH sensitivity, appropriate degradation, rates displayed favorable adhesion properties. Notably, it demonstrated excellent resistance against Escherichia coli Staphylococcus aureus, highlighting its potential create optimal wound environment. In vivo studies further confirmed hydrogel's exceptional positioning as material for (ESD) surgery. Moreover, cell experiments hemolysis tests revealed high biocompatibility, supporting their facilitate healing iatrogenic post-ESD conclusion, our hydrogels hold great promise treatment materials ESD-induced given outstanding
Язык: Английский
Процитировано
11ACS Biomaterials Science & Engineering, Год журнала: 2022, Номер 8(5), С. 2088 - 2095
Опубликована: Апрель 22, 2022
Ulcerative colitis (UC) is a chronic inflammatory disease, which deleteriously affects the lower end of gastrointestinal tract, i.e., colon and rectum. UC colonic homeostasis disrupts intestinal barrier functions. Intestinal tissue damage activates immune system collectively worsens disease condition via production various cytokines. Ongoing therapeutics have marked limitations like rapid clearance, extensive first-pass metabolism, poor drug absorption, very low solubility, bioavailability, etc. Because these restrictions, management demands rational approach that selectively delivers at site action to overcome therapeutic limiting factors. Metallic nanoparticles (NPs) good efficacy against colitis, but their uses are limited due adverse effects on biological system. In this study, we used biocompatible thiol-functionalized cellulose-grafted copper oxide (C-CuI/IIO NPs) treat UC. The metal NPs alleviated as evidenced by length observed physical parameters. Analysis histopathology demonstrated recovery architecture damaged dextran sulfate sodium-induced colitis. Treatment with C-CuI/IIO reduced disintegration goblet cells retainment sulfomucin. Significant downregulation markers MPO activity, well levels nitrite TNF-α, was found following NP treatment. observations from study suggested intrarectal treatment cellulose-based successfully combated condition.
Язык: Английский
Процитировано
15ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Янв. 26, 2025
Colorectal cancer is a lethal malignancy that begins from acquired/inherent premalignant lesions. Thus, targeting these lesions at an early stage of the disease could impede oncogenesis and maximize efficacy. The present work underscores combinatorial therapy paclitaxel (PTX) glycyrrhizin (GL) delivered via gelatin-derived core-shell nanoparticles [AC-PCL(GL + PTX)-GNPs] for effective management precancerous desolvation method was adopted to prepare GL-loaded gelatin (GL-GNPs), which were coated with PTX AC-PCL. prepared NPs exhibited optimal physical attributes had spherical morphology, as analyzed by transmission electron microscopy field-emission scanning microscopy. In vitro release studies revealed sustained ∼96 h. Cell culture in HTC 116, HT-29 cells showed synergistic action CI < 0.9 DRI > 1. Moreover, AC-PCL(GL PTX)-GNPs amplified intracellular uptake thus significantly reduced IC50. Pharmacokinetic substantiated pharmacokinetic parameters (AUC0-∞, Cmax, etc.). vivo 1,2-dimethyl hydrazine-induced model decrease number lesions, mucin depletion, subside infiltrations. An immunohistochemical study elevated expression caspase-9 suppressed VEGF Ki-67. Toxicity insignificant changes systemic biomarkers along no alterations organ morphology hemocompatibility. essence, render competent safer tactic regulate early-stage
Язык: Английский
Процитировано
0BioNanoScience, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
0Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
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