Chemistry - An Asian Journal,
Год журнала:
2022,
Номер
17(22)
Опубликована: Сен. 7, 2022
Abstract
Cancer
is
one
of
the
most
intractable
diseases
in
world
because
its
high
recurrence
rate,
metastasis
rate
and
lethality
rate.
Traditional
chemotherapy,
radiotherapy
surgery
have
unsatisfactory
therapeutic
effects
cause
many
severe
side
at
same
time.
Hydrogel
a
new
type
biomaterial
with
advantages
good
biocompatibility
easy
degradation,
which
can
be
used
as
carrier
functional
nanomaterials
for
tumor
therapy.
Herein,
we
represent
progress
hydrogels
different
skeletons
their
application
treatment.
The
are
listed
polyethylene
glycol‐based
hydrogels,
chitosan‐based
peptide‐based
hyaluronic
acid‐based
steroid‐based
other
by
skeletons,
properties,
modifications
toxicities
were
introduced.
Some
representative
applications
combined
nanomaterial
photodynamic
therapy,
photothermal
sonodynamic
chemodynamic
therapy
synergistic
highlighted.
Biomaterials Science,
Год журнала:
2024,
Номер
12(19), С. 4855 - 4874
Опубликована: Янв. 1, 2024
In
recent
years,
supramolecular
hydrogels
have
made
groundbreaking
research
progress
in
biomedical
fields
such
as
drug
delivery,
biosensing,
imaging
analysis,
and
tissue
engineering.
Peptides,
with
their
unique
characteristics
of
facile
preparation,
low
immunogenicity
easy
biodegradability,
are
commonly
used
building
blocks
hydrogels.
Peptide-based
loaded
drugs,
prepared
Gels,
Год журнала:
2022,
Номер
8(11), С. 741 - 741
Опубликована: Ноя. 15, 2022
At
present,
an
oral
tumor
is
usually
treated
by
surgery
combined
with
preoperative
or
postoperative
radiotherapies
and
chemotherapies.
However,
traditional
chemotherapies
frequently
result
in
substantial
toxic
side
effects,
including
bone
marrow
suppression,
malfunction
of
the
liver
kidneys,
neurotoxicity.
As
a
new
local
drug
delivery
system,
smart
system
based
on
hydrogel
can
control
release
time
space,
effectively
alleviate
avoid
these
problems.
Environmentally
responsive
hydrogels
for
could
be
triggered
temperature,
photoelectricity,
enzyme,
pH.
An
overview
most
recent
research
their
controlled-release
systems
treatment
cancer
given
this
review.
It
anticipated
that
method
environment-responsive
benefits
will
offer
novel
technique
low-toxicity
highly
effective
malignancy.
Biomaterials Science,
Год журнала:
2023,
Номер
11(8), С. 2678 - 2692
Опубликована: Янв. 1, 2023
The
common
skeletons
and
formulations
of
hydrogels
for
tumor
recurrence
are
summarized.
review
emphasizes
unique
properties
postoperative
prevention
provides
a
broader
insight
into
clinical
transformation
hydrogels.
Comprehensive Reviews in Food Science and Food Safety,
Год журнала:
2023,
Номер
22(4), С. 3053 - 3083
Опубликована: Май 17, 2023
Abstract
Due
to
the
unique
and
excellent
biological,
physical,
chemical
properties
of
peptide
hydrogels,
their
application
in
biomedical
field
is
extremely
wide.
The
applications
hydrogels
are
closely
related
responsiveness
properties.
However,
its
defects
mechanical
properties,
stability,
toxicity
limit
food
field.
In
this
review,
we
focus
on
fabrication
methods
through
chemical,
biological
stimulations.
addition,
functional
design
by
incorporation
with
materials
discussed.
Meanwhile,
such
as
stimulus
responsiveness,
biocompatibility,
antimicrobial
rheology,
stability
reviewed.
Finally,
hydrogel
summarized
prospected.
Pharmaceutics,
Год журнала:
2022,
Номер
14(10), С. 2028 - 2028
Опубликована: Сен. 23, 2022
Cancer
seriously
threatens
human
health.
Surgery,
radiotherapy
and
chemotherapy
are
the
three
pillars
of
traditional
cancer
treatment,
with
targeted
therapy
immunotherapy
emerging
over
recent
decades.
Standard
drug
regimens
mostly
executed
via
intravenous
injection
(IV),
especially
for
agents.
However,
these
treatments
pose
severe
risks,
including
off-target
toxic
side
effects,
low
accumulation
penetration
at
tumor
site,
repeated
administration,
etc.,
leading
to
inadequate
treatment
failure
meet
patients’
needs.
Arising
from
challenges,
a
local
regional
anticancer
strategy
has
been
proposed
enhance
therapeutic
efficacy
concomitantly
reduce
systemic
toxicity.
With
advances
in
biomaterials
our
understanding
microenvironment,
situ
stimulus-responsive
hydrogels,
also
called
smart
have
extensively
investigated
due
their
injectability,
compatibility
responsiveness
various
stimuli
(pH,
enzyme,
heat,
light,
magnetic
fields,
electric
fields
etc.).
Herein,
we
focus
on
latest
progress
regarding
that
cause
phase
transition
release
hydrogels
therapy.
Additionally,
challenges
future
trends
reviewed
delivery
summarized
proposed.
New Journal of Chemistry,
Год журнала:
2023,
Номер
47(30), С. 14261 - 14272
Опубликована: Янв. 1, 2023
Designing
cancer
therapeutics
that
can
ameliorate
the
high
dose
related
side
effects
of
chemotherapy
and
are
safer,
more
effective,
site
specific
with
a
stimuli
response
has
received
attention
in
recent
times.
Biomacromolecules,
Год журнала:
2023,
Номер
24(8), С. 3755 - 3766
Опубликована: Июль 28, 2023
The
DNA
damage
repair
of
tumor
cells
limits
the
effect
photothermal
therapy
(PTT),
and
high
temperatures
induced
by
PTT
can
adjacent
normal
tissues.
To
overcome
these
limitations,
we
developed
a
novel
composite
hydrogel
(OLA-Au-Gel)
based
on
chitosan
(CS)
β-glycerophosphate
(β-GP),
which
encapsulated
olaparib-liposomes
(OLA-lips)
CS-capped
gold
nanoparticles
(CS-AuNPs).
OLA-Au-Gel
achieved
combination
mild
(mPTT)
CS-AuNPs
inhibition
OLA.
showed
good
biocompatibility,
injectability,
response.
Under
near-infrared
laser
irradiation,
inhibited
proliferation
cells,
generation
reactive
oxygen
species
in
vitro,
effectively
growth
breast
tumors
vivo.
shows
promising
application
prospect
for
inhibiting
development
improving
antitumor
effect.
Collectively,
propose
strategy
enhanced
mPTT
inhibition.
