Synthesis of 2‐Pyrones by Base‐Induced [3+3] Annulation Reaction of Phenacyl Phosphonium Ylides with Cyclopropenones

Asian Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 18, 2024

Abstract The base‐induced [3+3] annulation reaction of phenacyl phosphonium ylides with cyclopropenones has been proposed. Various polysubstituted 2‐pyrones are achieved in moderate to good yields through C−P bond cleavage and C−O/C−C coupling under simple easy‐to‐operate conditions. synthetic application mechanism have also preliminarily explored gain a deeper understanding this strategy practicality details. This protocol offers an alternative approach for the synthesis useful 2‐pyrone derivatives.

Язык: Английский

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Synthesis of 4‐Cyclobutene‐Isoquinolines From Aryl Imidates by Ru(II)‐Catalyzed Domino C–H Activation/Cyclization

Applied Organometallic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 13, 2024

ABSTRACT A highly regioselective approach for constructing 4‐cyclobutene‐isoquinoline derivatives through ruthenium‐catalyzed domino C–H activation/cyclization of aryl imidates has been demonstrated. This new transformation tolerates various substituted functional groups on and propargylic monofluoroalkynes, resulting in the corresponding products being delivered moderate yields.

Язык: Английский

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Aromatic CH Bond Functionalization with Carbene Precursors

Handbook of CH‐Functionalization, Год журнала: 2022, Номер unknown, С. 1 - 35

Опубликована: Ноя. 29, 2022

Abstract Metal carbene‐based cross‐coupling reactions have been established as a highly efficient approach for constructing carbon–carbon bonds. In the past decade, this type of newly developed reaction has successfully merged into CH bond activations. This article summarizes recent developments in aromatic functionalizations with carbene precursors. All transformations shown are mechanistically related, common feature metal formation and subsequent migratory insertion. The is mainly divided two parts according to products: namely without cyclization or cyclization.

Язык: Английский

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Cu‐catalyzed synthesis of 1‐naphthols with terminal alkynes and 2‐bromoaryl ketones

Applied Organometallic Chemistry, Год журнала: 2022, Номер 36(9)

Опубликована: Июнь 22, 2022

A Cu‐catalyzed straightforward synthesis of 1‐naphthols via an 6‐endo‐dig cyclization terminal alkynes with 2‐bromoaryl ketones in water is reported. The Cu(I) catalytic system tolerates various electron‐withdrawing and electron‐donating functional groups on both substrates exhibits unique selectivity to give moderate good yields.

Язык: Английский

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