Asian Journal of Organic Chemistry,
Год журнала:
2022,
Номер
11(8)
Опубликована: Июль 8, 2022
Abstract
An
efficient
synthesis
of
biologically
important
quinazolinones
via
using
dimethyl
sulfoxide
as
a
synthon
has
been
developed.
This
reaction
proceeds
smoothly
to
obtain
the
corresponding
products
in
good
yield
under
metal
free
conditions
and
shows
an
excellent
functional
group
tolerance.
A
preliminary
mechanistic
study
indicates
that
C2
hydrogen
synthesized
heterocycles
come
from
sulfoxide.
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(5), С. 3156 - 3166
Опубликована: Фев. 14, 2022
A
NaN(SiMe3)2/CsTFA
copromoted
aminobenzylation/cyclization
reaction
of
2-isocyanobenzaldehydes
with
toluene
derivatives
or
benzyl
compounds
has
been
developed.
The
works
a
broad
range
and
compounds,
provides
simple
efficient
strategy
for
the
synthesis
4-benzyl-substitued
dihydroquinazoline
quinazoline
from
easily
available
acyclic
starting
materials
in
single
step.
Further
applications,
including
quinazoline,
dihydroindolo[1,2-c]quinazoline,
dihydro-8H-isoquinolino[2,3-c]quinazoline,
demonstrated
tremendous
potential
tandem
reaction.
Synthesis,
Год журнала:
2022,
Номер
54(12), С. 2876 - 2884
Опубликована: Янв. 31, 2022
Abstract
An
efficient
iridium-catalyzed
acceptorless
dehydrogenative
coupling
(ADC)
reaction
for
the
preparation
of
various
quinazolines
from
2-aminoarylmethanols
and
amides
or
nitriles
had
been
developed.
A
wide
range
substituted
2-aminobenzyl
alcohols
(hetero)aryl
alkyl
benzamides
were
well
compatible
to
afford
in
excellent
yields.
Merits
this
new
strategy
are
high
atom-economy,
mild
conditions,
simple
operation,
methodology
is
suitable
a
variety
substrates.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(18), С. 3263 - 3272
Опубликована: Авг. 20, 2022
Abstract
2‐Mono‐
or
2,3‐disubstituted
pyrimido[1,2‐
b
]indazoles
are
synthesized
by
a
(3+2+1)
three‐component
cyclization
of
3‐aminoindazoles,
ketones,
and
N,N
‐dimethylaminoethanol
as
methine
source.
The
reaction
demonstrates
good
tolerance
both
aromatic
aliphatic
well
various
substitution
patterns
in
air.
A
plausible
mechanism
is
discussed.
magnified
image
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
89(1), С. 152 - 162
Опубликована: Дек. 12, 2023
Reactions
with
diverse
C1
synthons
to
realize
homologation
were
well
explored.
However,
homologations
occurring
twice
one
synthon
in
a
reaction
less
reported.
We
disclose
herein
Cu(II)-catalyzed
novel
and
efficient
synthesis
of
2H-chromenes
from
2-naphthols,
1,3-diketones,
N,N-dimethylethanolamine
(DMEA)
as
dual
carbon
synthon.
Various
different
functional
groups
are
constructed
moderate
good
yields.
This
is
the
first
report
that
DMEA
acts
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(16), С. 11253 - 11260
Опубликована: Авг. 8, 2022
A
Rh(III)-catalyzed
tandem
reaction
for
the
synthesis
of
(quinazolin-2-yl)methanone
derivatives
has
been
explored
from
2,1-benzisoxazoles
and
α-azido
ketones.
The
transformation
involves
denitrogenation
ketones,
aza-[4
+
2]
cycloaddition,
ring
opening,
dehydration
aromatization
processes.
Notably,
cycloaddition
an
imine
rhodium
complex
intermediate
with
is
key
to
this
reaction.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(9), С. 6168 - 6175
Опубликована: Апрель 20, 2023
This
study
reports
a
carbonylative
acetylation
for
the
synthesis
of
N-phenyl-N-(pyridin-2-yl)acetamides
using
N,N-dimethylformamide
(DMF)
as
methyl
source
and
CO
carbonyl
source.
Interestingly,
dimethyl
sulfoxide
(DMSO)
can
be
also
used
when
only
DMSO
solvent.
Mechanistic
studies
DMSO-d6
revealed
that
group
was
derived
from
DMF
instead
mixed
These
results
indicated
preferential
Synthesis,
Год журнала:
2024,
Номер
56(12), С. 1932 - 1940
Опубликована: Янв. 9, 2024
Abstract
A
simple
and
efficient
method
for
the
synthesis
of
1,4-dihydropyridines
from
amines,
N,N-dimethyl
enaminone
N,N-dimethylaminoethanol
in
a
four-component
[2+1+2+1]
annulation
catalyzed
by
FeCl3
has
been
established,
where
was
applied
as
methine
source.
The
procedure
executed
smoothly,
resulting
wide
range
with
moderate
to
good
yields.
Additionally,
these
fluorophores
exhibited
photophysical
characteristics.
In
this
chapter,
we
have
summarized
some
special
and
representative
transformations
using
DMSO
as
a
green
solvent
in
organic
synthesis
over
the
last
5
years.
contrast
to
previous
reviews,
focus
more
on
situ
activation
pattern
of
by
summarizing
different
fragmentation
processes
show
reaction
initiation
pathway.
For
example,
Pummerer-type,
Selectfluor-enabled,
electrocatalytic-enabled,
photocatalytic-enable
were
classified
discussed
detail.
each
pattern,
several
recent
are
listed,
along
with
their
selected
products
generality,
while
detailed
mechanism
is
also
provided
after
example
facilitate
reader's
understanding
illustrate
chemical
principles.
We
believe
that
chapter
provides
unique
perspective
lead
better
DMSO-mediated
integrated
information
for
researchers
who
keen
select
method
activation.
Current Organic Chemistry,
Год журнала:
2024,
Номер
28(4), С. 305 - 318
Опубликована: Фев. 1, 2024
Abstract::
This
study
aims
to
develop
a
practical
and
facile
one-pot
synthesis
of
2-
substituted
quinazolines.
Using
commercially
available
structurally
simple
ruthenium(
II)
complex
as
the
catalyst
synthesize
series
quinazoline
derivatives
via
acceptorless
dehydrogenative
coupling.
The
mechanism
this
reaction
was
explored
by
control
DFT
calculation.
protocol
offers
access
diverse
array
(52
examples)
in
moderate
excellent
yields
(29%-98%).
In
summary,
we
have
developed
an
efficient
ruthenium
(II)-catalyzed
ADC
under
air
atmosphere.
only
produces
hydrogen
water
by-products,
serving
sustainable
atom-efficient
synthetic
approach.
