Bulletin of the Medical Institute after Mehrabyan,
Год журнала:
2023,
Номер
unknown, С. 19 - 41
Опубликована: Янв. 1, 2023
Производные
пиридиновых
солей
представляют
интерес
как
с
химической,
так
и
фармакологической
точки
зрения.
Обладая
высокой
биологической
активностью,
пиридины
обеспечивают
развитие
синтеза
новых
систем
открытие
потенциальных
лекарств
на
их
основе.
В
данной
работе
комплексно
представлены
основные
исследования,
проведенные
в
последние
годы
по
четвертичным
солям
пиридина,
обладающим
активностью.
//
Derivatives
of
pyridinium
salts
are
interest
both
from
a
chemical
and
pharmacological
point
view.
Having
high
biological
activity,
pyridines
ensure
the
development
synthesis
new
heterocyclic
systems
discovery
potential
drugs
based
on
them.
All
this
will
facilitate
transition
to
salt
forms
highly
active
compounds.
This
work
provides
brief
overview
pyridine
salts,
including
synthesis,
nucleophilic
reactivity,
possible
ylide-cyclic
photochemical
reactions,
catalysis,
as
well
application
spectrum
effects
ionic
liquids
(PyILs).
The
main
research
conducted
in
recent
years
quaternary
with
activity
is
comprehensively
presented.
Molecules,
Год журнала:
2023,
Номер
28(11), С. 4410 - 4410
Опубликована: Май 29, 2023
[3
+
2]
Cycloaddition
reactions
of
heteroaromatic
N-ylides
with
electron-deficient
olefins
have
been
developed.
The
N-ylides,
in
situ
generated
from
N-phenacylbenzothiazolium
bromides,
can
smoothly
react
maleimides
under
very
mild
conditions,
affording
fused
polycyclic
octahydropyrrolo[3,4-c]pyrroles
good-to-excellent
isolated
yields.
This
reaction
concept
could
also
be
extended
to
3-trifluoroethylidene
oxindoles
and
benzylidenemalononitriles
as
for
accessing
highly
functionalized
polyheterocyclic
compounds.
A
gram-scale
experiment
was
carried
out
verify
the
practicability
methodology.
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
88(1), С. 534 - 539
Опубликована: Дек. 19, 2022
We
report
an
efficient
alkyl
transfer
strategy
for
the
direct
β-alkylation
of
chalcones
using
commercially
available
bromides
as
reagents.
In
this
transformation,
ortho-phosphanyl
substituent
in
is
crucial
controlling
their
reactivity
and
selectivity.
It
also
serves
a
reliable
shuttle
to
transform
electrophilic
into
nucleophilic
species
form
quaternary
phosphonium
salts
group
effectively
β-position
chalcones.
This
can
be
further
extended
alkenylation
benzaldehydes
assemble
functionalized
polyenes.
Chemical Communications,
Год журнала:
2023,
Номер
60(8), С. 992 - 995
Опубликована: Дек. 21, 2023
Herein,
we
report
an
efficient
and
easily
operable
method
to
halohydroxylate
pyridiniums
through
interrupted
dearomative
reduction
strategy.
In
this
process,
make
the
most
of
halide
anion
from
pyridinium
salts
by
performing
reaction
in
DMSO
without
need
external
HX
added.
Notably,
changing
solvents
into
Et
The
reaction
of
arylidene-α-amino
esters
with
electrophilic
alkenes
to
yield
the
Michael
type
addition
compounds
is
optimized
using
several
phosphines
as
organocatalysts.
transformation
very
complicated
due
generation
final
compounds,
including
those
derived
from
1,3-dipolar
cycloadditions.
For
this
reason,
selection
conditions
a
complex
task
and
slow
acrylic
system
important
complete
reaction.
study
variation
structural
components
starting
imino
ester
performed
well
expansion
other
electron-poor
alkenes.
crude
products
have
purity
higher
than
90%
in
most
cases
without
any
purification.
A
plausible
mechanism
detailed
based
on
bibliography
experimental
results.
synthesis
pyroglutamate
entities,
after
reduction
group
cyclization,
high
yields.
In
addition,
hydrolysis
group,
under
acidic
media,
represents
direct
access
glutamate
surrogates.
Molecules,
Год журнала:
2024,
Номер
29(2), С. 342 - 342
Опубликована: Янв. 10, 2024
The
reaction
of
arylidene-α-amino
esters
with
electrophilic
alkenes
to
yield
Michael-type
addition
compounds
is
optimized
using
several
phosphines
as
organocatalysts.
transformation
very
complicated
due
the
generation
final
compounds,
including
those
derived
from
1,3-dipolar
cycloadditions.
For
this
reason,
selection
conditions
a
complex
task
and
slow
acrylic
system
important
complete
process.
study
variation
in
structural
components
starting
imino
ester
performed
well
expansion
other
electron-poor
alkenes.
crude
products
have
purity
higher
than
90%
most
cases
without
any
purification.
A
plausible
mechanism
detailed
based
on
bibliography
experimental
results.
synthesis
pyroglutamate
entities,
after
reduction
group
cyclization,
high
yields.
In
addition,
hydrolysis
group,
under
acidic
media,
represents
direct
access
glutamate
surrogates.
Organic Letters,
Год журнала:
2024,
Номер
26(34), С. 7144 - 7148
Опубликована: Авг. 19, 2024
Dearomative
trifunctionalization
of
quinolinium
salts
is
one
the
most
straightforward
approaches
to
access
biologically
relevant
multisubstituted
tetrahydroquinolines.
However,
research
in
this
field
still
its
infancy.
Here,
we
report
a
base-controlled
regiodivergent
dearomative
strategy
for
transforming
quinoliniums
into
two
kinds
structurally
intriguing
tetrahydroquinoline
polycycles
through
one-pot
three-component
cascade
annulation.
The
key
situ
generation
"Nu–E–Nu"
trifunctional
reagent
that
can
precisely
identify
matched
reactive
sites
quinoliniums.
Green Synthesis and Catalysis,
Год журнала:
2022,
Номер
unknown
Опубликована: Июнь 1, 2022
We
demonstrated
herein
an
electrochemical
dearomatizative
alkylation
of
Katritzky
salts,
wherein
salts
were
harnessed
as
both
radical
acceptors
and
donors.
A
wide
range
privileged
dihydropyridine
scaffolds
was
constructed
with
good
to
excellent
yields.
Cyclic
voltammetry
(CV)
electron
paramagnetic
resonance
(EPR)
results
confirmed
the
key
intermediates-dihydropyridine
radicals
gram-scale
reaction
highlighted
practical
sustainable
feature
newly
developed
protocol.
