Current Organic Chemistry,
Год журнала:
2023,
Номер
27(12), С. 997 - 1009
Опубликована: Июнь 1, 2023
Abstract:
Nitrogen
ring
junction
heterocycles
play
a
crucial
role
in
synthetic
organic
chemistry
due
to
their
remarkable
activity.
The
fused
nitrogen
compounds
are
abundant
nature;
they
have
excellent
biological
activity
and
used
against
various
health
issues.
To
make
selective
products
from
the
heterocycles,
expensive
chemicals
catalysts,
like
transition
metal
complexes
composites,
required.
neglect
drawbacks
of
conventional
synthesis
methods
long
reaction
times,
by-product
formation,
lower
selectivity,
low
yields,
an
alternative
nonconventional
light-mediated
techniques
can
be
opted
for.
light
source
uses
radical
mechanism
that
reduces
provides
regio-selective
product,
increases
yield,
decreases
time,
is
cost-effective,
does
not
require
special
catalysts
or
chemicals.
There
variety
sources,
viz.,
UV,
visible,
IR,
laser,
X-ray.
visible
light,
white,
green,
blue
LED
sources
widely
photochemical
method.
This
review
emphasizes
nitrogen-ring
heterocyclic
compounds.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(13), С. 2205 - 2210
Опубликована: Май 20, 2022
Abstract
A
synthetic
method
of
o
‐sulfanylanilines
from
cyclohexanones,
amines,
and
thiophenols
under
transition‐metal‐free
conditions
is
disclosed.
This
the
first
report
on
direct
thioamination
cyclohexanones
via
N
‐iodosuccinimide
(NIS)
promoted
oxidative
dehydroaromatization.
Non‐aromatic
were
smoothly
dehydrogenated,
acted
as
an
aryl
source
using
oxygen
a
green
oxidant.
The
capacity
resultant
for
synthesis
‐arylphenothiazines
has
been
further
demonstrated.
magnified
image
ACS Catalysis,
Год журнала:
2023,
Номер
13(22), С. 14763 - 14769
Опубликована: Ноя. 1, 2023
This
paper
describes
an
acceptorless
dehydrogenation
process
of
N-heterocycles
by
a
photoelectrochemical
(PEC)
method
under
simulated
sunlight
irradiation
at
room
temperature.
A
series
N-heterocyclic
compounds,
including
DHPMs,
dihydroquinazolin-4(1H)-ones,
tetrahydroisoquinolines,
and
cyclic
sulfonamides,
were
effectively
dehydrogenated
into
the
corresponding
products
(up
to
97%
yield)
accompanied
simultaneous
hydrogen
evolution
in
PEC
cell
comprising
mesoporous
BiVO4
photoanode
Pt
electrode.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(12), С. 8896 - 8905
Опубликована: Июнь 10, 2024
Endocyclic
1-azaallyl
anions
engage
allyl
acetates
in
a
palladium-catalyzed
allylation
followed
by
reduction
to
give
unprotected
2-(hetero)aryl-3-allylpiperidines
and
2-allyl-3-arylmorpholines,
products
not
easily
accessible
other
means.
The
group
is
then
readily
transformed
into
variety
of
functional
groups.
Preliminary
studies
on
the
asymmetric
variant
reaction
using
an
enantiomerically
pure
BI-DIME-type
ligand
provide
product
with
moderate
enantioselectivity.
Computational
suggest
that
energy
barriers
inner-sphere
reductive
elimination
outer-sphere
nucleophilic
substitution
are
almost
same,
which
makes
both
them
possible
pathways.
In
addition,
mechanism
displays
enantiodiscriminating
C–C
bond
forming
step,
while
much
less
selective,
combined
Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
Herein,
we
have
demonstrated
the
design
and
synthesis
of
a
novel
Ni-immobilized
MOF
as
heterogeneous
catalyst
for
dehydrogenation
N-heterocycles.
A
series
five
six-membered
N-heteroarenes
bearing
one
or
more
heteroatoms
were
synthesized
in
up
to
98
%
yield
(>33
examples).
Late
stage
functionalization
β-glucuronides
inhibitor,
antimalarial
drug
quinine,
nonsteroidal
anti-inflammatory
(NSAID)
indomethacin
obtained
under
milder
reactions
conditions.
mechanistic
studies
revealed
detection
H
Current Organic Chemistry,
Год журнала:
2023,
Номер
27(12), С. 997 - 1009
Опубликована: Июнь 1, 2023
Abstract:
Nitrogen
ring
junction
heterocycles
play
a
crucial
role
in
synthetic
organic
chemistry
due
to
their
remarkable
activity.
The
fused
nitrogen
compounds
are
abundant
nature;
they
have
excellent
biological
activity
and
used
against
various
health
issues.
To
make
selective
products
from
the
heterocycles,
expensive
chemicals
catalysts,
like
transition
metal
complexes
composites,
required.
neglect
drawbacks
of
conventional
synthesis
methods
long
reaction
times,
by-product
formation,
lower
selectivity,
low
yields,
an
alternative
nonconventional
light-mediated
techniques
can
be
opted
for.
light
source
uses
radical
mechanism
that
reduces
provides
regio-selective
product,
increases
yield,
decreases
time,
is
cost-effective,
does
not
require
special
catalysts
or
chemicals.
There
variety
sources,
viz.,
UV,
visible,
IR,
laser,
X-ray.
visible
light,
white,
green,
blue
LED
sources
widely
photochemical
method.
This
review
emphasizes
nitrogen-ring
heterocyclic
compounds.
