Functional chromopeptide nanoarchitectonics: molecular design, self-assembly and biological applications

Chemical Society Reviews, Год журнала: 2023, Номер 52(8), С. 2688 - 2712

Опубликована: Янв. 1, 2023

An overview of chromopeptide self-assembly is presented to systematically understand this kind newly emerging peptide building block.

Язык: Английский

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Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications

Bioactive Materials, Год журнала: 2024, Номер 35, С. 181 - 207

Опубликована: Фев. 2, 2024

Peptide molecules have design flexibility, self-assembly ability, high biocompatibility, good biodegradability, and easy functionalization, which promote their applications as versatile biomaterials for tissue engineering biomedicine. In addition, the functionalization of self-assembled peptide nanomaterials with other additive components enhances stimuli-responsive functions, promoting function-specific that induced by both internal external stimulations. this review, we demonstrate recent advance in molecular design, self-assembly, functional tailoring, biomedical peptide-based nanomaterials. The strategies on synthesis single, dual, multiple various dimensions are analyzed, regulation active such metal/metal oxide, DNA/RNA, polysaccharides, photosensitizers, 2D materials, others discussed. designed temperature-, pH-, ion-, light-, enzyme-, ROS-responsive abilities drug delivery, bioimaging, cancer therapy, gene antibacterial, well wound healing dressing presented This comprehensive review provides detailed methodologies advanced techniques from biology, materials science, nanotechnology, will guide inspire level peptides specific functions applications.

Язык: Английский

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Deep Downregulation of PD‐L1 by Caged Peptide‐Conjugated AIEgen/miR‐140 Nanoparticles for Enhanced Immunotherapy

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(18)

Опубликована: Фев. 28, 2022

Downregulating programmed cell death ligand 1(PD-L1) protein levels in tumor cells is an effective way to achieve immune system activation for oncology treatment, but current strategies are inadequate. Here, we design a caged peptide-AIEgen probe (GCP) self-assemble with miR-140 forming GCP/miR-140 nanoparticles. After entering cells, disassembles the presence of Cathepsin B (CB) and releases GO203 peptide, PyTPA. Peptide decages highly reductive intracellular environment binds mucin 1 (MUC1), thereby downregulating expression PD-L1. Meanwhile, reduces PD-L1 by targeting downregulation mRNA. Under action PyTPA-mediated photodynamic therapy (PDT), tumor-associated antigens released, triggering attack on cells. This multiple mechanism-based strategy deeply activates thus achieves immunotherapy.

Язык: Английский

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Near Infrared Photoimmunotherapy: A Review of Recent Progress and Their Target Molecules for Cancer Therapy

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2655 - 2655

Опубликована: Янв. 31, 2023

Near infrared photoimmunotherapy (NIR-PIT) is a newly developed molecular targeted cancer treatment, which selectively kills cells or immune-regulatory and induces therapeutic host immune responses by administrating targeting moiety conjugated with IRdye700. The local exposure to near-infrared (NIR) light causes photo-induced ligand release reaction, damage the target cell, resulting in immunogenic cell death (ICD) little no side effect surrounding normal cells. Moreover, NIR-PIT can generate an response distant metastases inhibit further attack combing regulatory other treatment modalities. Several recent improvements have been explored such as catheter-driven NIR delivery, real-time monitoring of cancer, development new molecule, leading being considered promising therapy. In this review, we discuss progress NIR-PIT, their mechanism design strategies for treatment. Furthermore, overall possible molecules application are briefly summarised.

Язык: Английский

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Near‐Infrared‐Responsive Rare Earth Nanoparticles for Optical Imaging and Wireless Phototherapy

Advanced Science, Год журнала: 2023, Номер 11(8)

Опубликована: Ноя. 9, 2023

Abstract Near‐infrared (NIR) light is well‐suited for the optical imaging and wireless phototherapy of malignant diseases because its deep tissue penetration, low autofluorescence, weak scattering, non‐invasiveness. Rare earth nanoparticles (RENPs) are promising NIR‐responsive materials, owing to their excellent physical chemical properties. The 4f electron subshell lanthanides, main group rare elements, has rich energy‐level structures. This facilitates broad‐spectrum light‐to‐light conversion other forms energy, such as thermal energies. In addition, abundant loadable modifiable sites on surface offer favorable conditions functional expansion RENPs. this review, authors systematically discuss processes mechanisms underlying response RENPs NIR summarize recent advances in applications imaging, photothermal therapy, photodynamic photoimmunotherapy, optogenetics, light‐responsive drug release. Finally, challenges opportunities application under activation considered.

Язык: Английский

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Bioactive Peptide Nanodrugs Based on Supramolecular Assembly for Boosting Immunogenic Cell Death‐Induced Cancer Immunotherapy

Small Methods, Год журнала: 2023, Номер 7(5)

Опубликована: Янв. 31, 2023

Abstract Immunogenic cell death (ICD)‐induced immunotherapy holds promise for complete elimination and long‐term protective immune responses against cancer by combining direct tumor killing antitumor response. Some therapeutic approaches (such as hyperthermia, photodynamic therapy, or radiotherapy) inducers (certain chemotherapy drugs, oncolytic viruses) have been devoted to initiating and/or boosting ICD, leading the activation of tumor‐specific responses. Recently, supramolecular assembled bioactive peptide nanodrugs employed improve efficacy ICD‐induced increasing targeted accumulation well responsive release ICD inducers, directly inducing high levels realizing simultaneous enhancement response through function active itself. Here, authors review based on assembly, mainly an intelligent delivery system, a inducer enhancer, induced immunotherapy. The functions diverse peptides used in construction are described. design mechanism synergetic effects combined critically emphasized.

Язык: Английский

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Cathepsin B Responsive Peptide–Purpurin Conjugates Assembly-Initiated in Situ Self-Aggregation for Cancer Sonotheranostics

Nano Letters, Год журнала: 2024, Номер 24(3), С. 950 - 957

Опубликована: Янв. 10, 2024

Sonodynamic therapy (SDT) was hampered by the sonosensitizers with low bioavailability, tumor accumulation, and therapeutic efficiency. In situ responsive sonosensitizer self-assembly strategy may provide a promising route for cancer sonotheranositics. Herein, an intelligent sonotheranostic peptide–purpurin conjugate (P18-P) is developed that can self-assemble into supramolecular structures via self-aggregation triggered rich enzyme cathepsin B (CTSB). After intravenous injection, versatile probe could achieve deep tissue penetration because of sequence P18-P. More importantly, CTSB-triggered strongly prolonged retention time, amplified photoacoustic imaging signal sensitive CTSB detection, boosted reactive oxygen species advanced SDT, evoking specific sonotheranostics. This serve as efficient platform early diagnosis activity effective therapy.

Язык: Английский

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Octa-Cationic Porphyrin-Functionalized Biocompatible Nanocomposite: A Promising Candidate for Enhanced Combinatorial Photodynamic and Photothermal Tumor Therapy

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 26, 2025

The integration of photodynamic therapy (PDT) and photothermal (PTT) offers a promising strategy for enhancing phototherapy efficiency. Herein, we present dual-functional, biocompatible nanocomposite system combination PDT/PTT therapy. utilizes highly nanoparticle assembled by an amphiphilic short peptide with the assistance Zn2+ as carrier. convertor is loaded within nanoparticle, while cationic porphyrin photosensitizer on surface. water-soluble (M8PzEOPP), designed eight positive charges, provides strong electrostatic interaction stable assembly This location-independent effectively maintains optical characteristics both convertor, endowing effective properties. exhibits excellent tumor-targeting accumulation behavior, low dark toxicity, robust extracellular biostability, high cell internalization Its enhanced performance in combinatorial demonstrated through vitro vivo experiments.

Язык: Английский

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Supramolecular Nanozymes Based on Self-Assembly of Biomolecule for Cancer Therapy

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 2043 - 2057

Опубликована: Фев. 1, 2025

Natural enzyme systems possess extraordinary functions and characteristics, making them highly appealing for use in eco-friendly technologies innovative cancer treatments. However, their inherent instability structural complexity often limit practical applications, leading to the exploration of biomolecular nanozyme alternatives. Supramolecular nanozymes, constructed using self-assembly techniques various non-covalent interactions, have emerged as a promising solution. Amino acids, peptides, protein motifs offer flexible building blocks constructing these nanozymes. Importantly, well-defined regulation mechanisms along with unique properties fundamental biological modules living systems-such selectivity, permeability, retention, biocompatibility-present new opportunities therapy. This review highlights recent advances supramolecular self-assembled including peroxidases, oxidases, catalases, superoxide dismutases, other systems, tumor Additionally, it discusses precise functional modulation through interactions therapeutic applications targeting microenvironment. These studies provide valuable insights that may inspire design novel nanozymes enhanced catalytic biocompatibility, tumor-killing efficacy.

Язык: Английский

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Light-based technologies in immunotherapy: advances, mechanisms and applications

Immunotherapy, Год журнала: 2025, Номер unknown, С. 1 - 9

Опубликована: Март 3, 2025

Light-based immunotherapy uses specific wavelengths of light to activate or modulate immune responses. It primarily employs two mechanisms: direct activation cells and indirect modulation the tumor microenvironment (TME). Several light-based technologies are under investigation clinical use in immunotherapy, including photodynamic (PDIT) photothermal therapy (PTT). Optogenetic tools have potential precisely control T-cell receptor activation, cytokine release, activity other effector cells. present innovative opportunities within realm immunotherapy. The ability regulate cell via optogenetics, alongside improved targeting cancer through photoimmunotherapy, signifies a transformative shift our strategies for modulation. Although many these remain experimental stage various applications, initial findings encouraging, especially concerning treatment Continued research trials essential fully harness capabilities technology context therapy.

Язык: Английский

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