Recent advances in multifunctional fluorescent probes for viscosity and analytes

Coordination Chemistry Reviews, Год журнала: 2021, Номер 453, С. 214336 - 214336

Опубликована: Дек. 4, 2021

Язык: Английский

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Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy

Chemical Society Reviews, Год журнала: 2022, Номер 51(21), С. 8957 - 9008

Опубликована: Янв. 1, 2022

We discuss recent advances made in the development of NIR fluorescence-emitting small organic molecules for tumor imaging and therapy.

Язык: Английский

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Solid‐state Fluorescence from Carbon Dots Widely Tunable from Blue to Deep Red through Surface Ligand Modulation

Angewandte Chemie International Edition, Год журнала: 2022, Номер 62(12)

Опубликована: Дек. 20, 2022

Carbon dots (CDs) find widespread attention due to their remarkable fluorescent and electronic properties. However, aggregation-caused quenching currently limits the application of CDs in colored displays. The construction with color-tunable solid-state fluorescence (SSF) is rarely reported, since preparation SSF technically challenging. Herein, through surface ligand modulation, an emission-color span almost 300 nm (from blue deep red) were obtained. In-depth structure-property studies reveal that intra- inter-molecular hydrogen-bonding inside provokes emission properties aggregated state. Photodynamic characterizations demonstrate wavelengths can be switched smoothly by deliberately altering conjugation ability between substituent ligands core. Three-dimensional printing patterning used create a range emissive objects, demonstrating commercial potential for use optical lamps.

Язык: Английский

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Design and Application of Fluorescent Probes to Detect Cellular Physical Microenvironments

Chemical Reviews, Год журнала: 2024, Номер 124(4), С. 1738 - 1861

Опубликована: Фев. 14, 2024

The microenvironment is indispensable for functionality of various biomacromolecules, subcellular compartments, living cells, and organisms. In particular, physical properties within the biological could exert profound effects on both cellular physiology pathology, with parameters including polarity, viscosity, pH, other relevant factors. There a significant demand to directly visualize quantitatively measure fluctuation in spatiotemporal resolution. To satisfy this need, analytical methods based fluorescence probes offer great opportunities due facile, sensitive, dynamic detection that these molecules enable varying settings from vitro samples live animal models. Herein, we focus types small molecule fluorescent measurement microenvironment, mechanical force, temperature, electron potential. For each parameter, primarily describe chemical mechanisms underlying how are correlated changes signals. This review provides an overview perspective development environment, expand knowledge process, enrich diagnostic tools human diseases.

Язык: Английский

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Stable, Bright, and Long-Fluorescence-Lifetime Dyes for Deep-Near-Infrared Bioimaging

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(31), С. 14351 - 14362

Опубликована: Июль 29, 2022

Near-infrared (NIR) fluorophores absorbing maximally in the region beyond 800 nm, i.e., deep-NIR spectral region, are actively sought for biomedical applications. Ideal dyes bright, nontoxic, photostable, biocompatible, and easily derivatized to introduce functionalities (e.g., bioconjugation or aqueous solubility). The rational design of such remains a major challenge. Silicon-substituted rhodamines have been successful bioimaging applications red region. longer-wavelength silicon-substituted congeners unknown date. We successfully prepared four bis-benzannulated rhodamine (ESi5a–ESi5d), with an efficient five-step cascade on gram-scale. Because extensive overlapping their HOMO–LUMO orbitals, ESi5a–ESi5d highly (λabs ≈ 865 nm ε > 105 cm–1 M–1). By restraining both rotational freedom via annulation vibrational silicon-imparted strain, fluorochromic scaffold ESi5 is rigid, resulting unusually long fluorescence lifetime (τ 700 ps CH2Cl2) high quantum yield (ϕ = 0.14 CH2Cl2). Their half-lives toward photobleaching 2 orders magnitude longer than current standard (ICG serum). They stable presence biorelevant concentration nucleophiles reactive oxygen species. minimally toxic readily metabolized. Upon tail vein injection ESi5a (as example), vasculature nude mouse was imaged signal-to-background ratio. broad potentials

Язык: Английский

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A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Апрель 27, 2022

Abstract The quality and application of super-resolution fluorescence imaging greatly lie in the dyes’ properties, including photostability, brightness, Stokes shift. Here we report a synergistic strategy to simultaneously improve such properties regular fluorophores. Introduction quinoxaline motif with fine-tuned electron density conventional rhodamines generates new dyes vibration structure inhibited twisted-intramolecular-charge-transfer (TICT) formation synchronously, thus increasing brightness photostability while enlarging fluorophore YL578 exhibits around twofold greater shift than its parental fluorophore, Rhodamine B. Importantly, Stimulated Emission Depletion (STED) microscopy, derived probe possesses superior renders threefold more frames carbopyronine based probes (CPY-Halo 580CP-Halo), known as photostable fluorophores for STED imaging. Furthermore, is well generalized offer class bright fluorescent long (up 136 nm) bioimaging biosensing.

Язык: Английский

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Coumarin-based near-infrared fluorogenic probes: Recent advances, challenges and future perspectives

Coordination Chemistry Reviews, Год журнала: 2023, Номер 480, С. 215020 - 215020

Опубликована: Янв. 25, 2023

Язык: Английский

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Two-Coordinate Thermally Activated Delayed Fluorescence Coinage Metal Complexes: Molecular Design, Photophysical Characters, and Device Application

Chemical Reviews, Год журнала: 2024, Номер 124(7), С. 4332 - 4392

Опубликована: Март 28, 2024

Since the emergence of first green light emission from a fluorescent thin-film organic emitting diode (OLED) in mid-1980s, global consumer market for OLED displays has flourished over past few decades. This growth can primarily be attributed to development noble metal phosphorescent emitters that facilitated remarkable gains electrical conversion efficiency, broadened color gamut, and vibrant image quality displays. Despite these achievements, limited abundance metals Earth's crust spurred ongoing efforts discover cost-effective electroluminescent materials. One particularly promising avenue is exploration thermally activated delayed fluorescence (TADF), mechanism with potential fully harness excitons OLEDs. Recently, investigations have unveiled TADF series two-coordinate coinage (Cu, Ag, Au) complexes. These organometallic materials exhibit distinctive behavior comparison their counterparts. They offer benefits such as tunable emissive colors, short lifetimes, high luminescent quantum yields, reasonable stability. Impressively, both vacuum-deposited solution-processed OLEDs incorporating achieved outstanding performance. review encompasses various facets on complexes, including molecular design, photophysical characterizations, elucidation structure–property relationships, applications.

Язык: Английский

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Lipid Droplet Targeting Type I Photosensitizer for Ferroptosis via Lipid Peroxidation Accumulation

Advanced Materials, Год журнала: 2023, Номер 36(4)

Опубликована: Ноя. 21, 2023

Abstract As an iron‐dependent lipid peroxidation (LPO) mediated cell death pathway, ferroptosis offers promises for anti‐tumor treatment. Photodynamic therapy (PDT) is ideal way to generate reactive oxygen species (ROS) LPO. However, the conventional PDT normally functions on subcellular organelles, such as endoplasmic reticulum, mitochondria, and lysosome, causing rapid before triggering ferroptosis. Herein, first droplet (Ld)‐targeting type I photosensitizer (PS) with enhanced superoxide anion (O 2 −· ) production, termed MNBS , reported. The newly designed PS selectively localizes at Ld in cells, causes cellular LPO accumulation by generating sufficient O upon irradiation, subsequently induces chronical PDT, achieving high‐efficient hypoxia normoxia. Theoretical calculations comprehensive characterizations indicate that targeting property generation of originate from elevated H‐aggregation tendency owing dispersed molecular electrostatic distribution. Further vivo studies using ‐encapsulated liposomes demonstrate excellent anti‐cancer efficacy well anti‐metastatic activity. This study a paradigm reinforced achieve ferroptosis‐mediated PDT.

Язык: Английский

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Chemical Approaches to Optimize the Properties of Organic Fluorophores for Imaging and Sensing

Angewandte Chemie International Edition, Год журнала: 2023, Номер 63(11)

Опубликована: Дек. 12, 2023

Abstract Organic fluorophores are indispensable tools in cells, tissue and vivo imaging, have enabled much progress the wide range of biological biomedical fields. However, many available dyes suffer from insufficient performances, such as short absorption emission wavelength, low brightness, poor stability, small Stokes shift, unsuitable permeability, restricting their application advanced imaging technology complex imaging. Over past two decades, efforts been made to improve these performances fluorophores. Starting with luminescence principle fluorophores, this review clarifies mechanisms performance for traditional a certain extent, systematically summarizes modified approaches optimizing properties, highlights typical applications improved sensing, indicates existing problems challenges area. This not only proves significance improving but also provide theoretical guidance development high‐performance

Язык: Английский

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