The
Minisci
alkylation
of
N-heteroarenes
with
unactivated
alkanes
under
external
oxidant-free
conditions
provides
an
economically
attractive
route
to
access
alkylated
but
remains
underdeveloped.
Herein,
a
new
electrophotocatalytic
strategy
alkyl
radicals
from
strong
C(sp3
)-H
bonds
was
reported
for
the
following
reactions
in
absence
chemical
oxidants.
This
realized
first
example
cerium-catalyzed
reaction
directly
abundant
excellent
atom
economy.
It
is
anticipated
that
general
design
principle
would
enrich
catalytic
strategies
explore
functionalizations
H2
evolution.
Journal of Chemistry,
Год журнала:
2024,
Номер
2024, С. 1 - 21
Опубликована: Май 31, 2024
Absorption
of
free
radicals
in
the
body
cannot
be
done
by
antioxidant
compounds
originating
from
human
body,
so
exogenous
antioxidants
are
required
to
help
their
natural
action.
Oxidative
stress
can
caused
an
imbalance
radical
inhibitors
and
accumulation
that
enter
cellular
structures.
Synthetic
found
external
not
primary
choice
because
they
harmful
carcinogenic.
Therefore,
using
ingredients
provides
a
necessary
alternative
constructing
novel
antioxidants.
Recent
studies
have
highlighted
critical
analysis
evaluation
flavonoids
unique
class
secondary
metabolites
plants
used
communities
as
traditional
therapeutics
with
proven
bioactivity.
This
could
support
new
discoveries
based
on
various
herbal
medicines
addition,
functional
effectiveness
against
radicals.
In
this
review,
there
several
strengths
discussion.
First,
study
takes
comprehensive
approach
covering
aspects,
including
properties
sources
radicals,
oxidative
relation
different
diseases,
defense
mechanisms,
specific
mechanisms
flavonoids.
Second,
focus
antioxidants,
especially
flavonoids,
also
discussion
about
clinical
applications
studies,
limitations,
global
perspectives,
future
research
directions
become
references
selection
medicines.
But,
constraints
should
considered
when
interpreting
findings
review.
mechanism
is
only
discussed
general
one
example
compound
(flavonoid)
has
potential
antioxidant.
lack
regarding
relationship
between
diseases
Third,
limited
number
investigated
some
discussed.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(15), С. 10899 - 10907
Опубликована: Апрель 3, 2024
In
the
long-standing
quest
to
synthesize
fundamental
building
blocks
with
key
functional
group
motifs,
photochemistry
in
recent
past
has
comprehensively
established
its
attractiveness.
Amino
alcohols
are
not
only
functionally
diverse
but
ubiquitous
biologically
active
realm
of
compounds.
We
developed
bench-stable
bifunctional
reagents
that
could
then
access
sparsely
reported
γ-amino
directly
from
feedstock
alkenes
through
energy
transfer
(EnT)
photocatalysis.
A
designed
1,3-linkage
across
is
made
possible
by
intervention
a
radical
Brook
rearrangement
takes
place
downstream
EnT-mediated
homolysis
our
reagent(s).
combination
experimental
mechanistic
investigations
and
detailed
computational
studies
(DFT)
indicates
chain
propagated
reaction
pathway.
Chem Catalysis,
Год журнала:
2024,
Номер
4(3), С. 100891 - 100891
Опубликована: Янв. 18, 2024
Harnessing
modern
catalytic
concepts
to
address
long-standing
challenges
in
carbohydrate
chemistry
has
garnered
substantial
interest
from
the
synthetic
community
recent
years.
In
particular,
usage
of
multiple
catalysts
for
sequential
one-pot
relay
reactions
already
contributed
major
benefits
accessing
oligosaccharides
past
two
decades.
contrast,
exploitation
synergistic
catalysis
glycosciences
is
only
its
infancy.
While
methods
combine
stepwise
into
a
single
flask
operation,
they
do
not
intrinsically
alter
reaction
mechanisms.
Conversely,
involves
creation
unique
mechanistic
pathways
by
merging
cycles.
At
nexus
cycles,
fertile
opportunities
arise
bond-forming
strategies
that
are
possible
within
individual
manifold.
The
realization
underexploited
potential
expected
accelerate
developments
field,
thereby
offering
stereoselective
entry
points
glycosidic
chemical
space
was
previously
inaccessible.
The
Minisci
alkylation
of
N-heteroarenes
with
unactivated
alkanes
under
external
oxidant-free
conditions
provides
an
economically
attractive
route
to
access
alkylated
but
remains
underdeveloped.
Herein,
a
new
electrophotocatalytic
strategy
alkyl
radicals
from
strong
C(sp3
)-H
bonds
was
reported
for
the
following
reactions
in
absence
chemical
oxidants.
This
realized
first
example
cerium-catalyzed
reaction
directly
abundant
excellent
atom
economy.
It
is
anticipated
that
general
design
principle
would
enrich
catalytic
strategies
explore
functionalizations
H2
evolution.
